Manteia

ENSMUSG00000032446

Mus musculus

Features

Gene ID:	ENSMUSG00000032446

Biological name :	Eomes

Synonyms :	Eomes / Eomesodermin homolog / O54839

Possible biological names infered from orthology :	eomesodermin / O95936

Species:	Mus musculus

Chr. number:	9
Strand:	1
Band:	F3
Gene start:	118478212
Gene end:	118486132

Corresponding Affymetrix probe sets:	10589994 (MoGene1.0st) 1426001_at (Mouse Genome 430 2.0 Array) 1435172_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000035020 Ensembl peptide - ENSMUSP00000107393 Ensembl peptide - ENSMUSP00000118079 NCBI entrez gene - 13813 See in Manteia. MGI - MGI:1201683 RefSeq - XM_006511940 RefSeq - NM_001164789 RefSeq - NM_010136 RefSeq Peptide - NP_001158261 RefSeq Peptide - NP_034266 swissprot - O54839 swissprot - F6VSW9 Ensembl - ENSMUSG00000032446

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
eomesa	ENSDARG00000006640	Danio rerio
eomesb	ENSDARG00000104243	Danio rerio
EOMES	ENSGALG00000027247	Gallus gallus
EOMES	ENSG00000163508	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Tbr1 / Q64336 / T-box brain protein 1 / Q16650* / T-box, brain 1*	ENSMUSG00000035033	46
Tbx21 / Q9JKD8 / T-box transcription factor TBX21 / Q9UL17* / T-box 21*	ENSMUSG00000001444	33
Mga / A2AWL7 / MAX-associated protein / Q8IWI9* / MGA, MAX dimerization protein*	ENSMUSG00000033943	21
Tbx19 / Q99ME7 / T-box transcription factor TBX19 / O60806* / T-box 19*	ENSMUSG00000026572	17
T / P20293 / brachyury, T-box transcription factor T / TBXT* / O15178* / T-box transcription factor T*	ENSMUSG00000062327	17

Protein motifs (from Interpro)

Interpro ID	Name
IPR001699	Transcription factor, T-box
IPR008967	p53-like transcription factor, DNA-binding
IPR018186	Transcription factor, T-box, conserved site
IPR032385	T-box transcription factor-associated
IPR036960	T-box superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0001706	endoderm formation	IMP
biological_process	GO:0001707	mesoderm formation	IMP
biological_process	GO:0001714	endodermal cell fate specification	IMP
biological_process	GO:0001824	blastocyst development	IMP
biological_process	GO:0001829	trophectodermal cell differentiation	IGI
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response	IDA
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007369	gastrulation	IEA
biological_process	GO:0007420	brain development	IEA
biological_process	GO:0010002	cardioblast differentiation	IMP
biological_process	GO:0010468	regulation of gene expression	IMP
biological_process	GO:0019827	stem cell population maintenance	IMP
biological_process	GO:0021772	olfactory bulb development	IMP
biological_process	GO:0021796	cerebral cortex regionalization	IMP
biological_process	GO:0021895	cerebral cortex neuron differentiation	IDA
biological_process	GO:0030154	cell differentiation	IMP
biological_process	GO:0032609	interferon-gamma production	IDA
biological_process	GO:0035914	skeletal muscle cell differentiation	IMP
biological_process	GO:0045597	positive regulation of cell differentiation	IGI
biological_process	GO:0045664	regulation of neuron differentiation	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	ISS
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0050767	regulation of neurogenesis	IMP
biological_process	GO:0060706	cell differentiation involved in embryonic placenta development	IMP
biological_process	GO:0060809	mesodermal to mesenchymal transition involved in gastrulation	IMP
cellular_component	GO:0005622	intracellular	IDA
cellular_component	GO:0005634	nucleus	IEA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0001102	RNA polymerase II activating transcription factor binding	IPI
molecular_function	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding	IDA
molecular_function	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IC
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0000774	reduced brain size	"smaller appearance of the brain" [J:35802]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0000812	abnormal dentate gyrus morphology	"absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0000819	abnormal olfactory bulb morphology	"malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0001330	abnormal optic nerve morphology	"malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Nf1^tm1Tyj/Nf1⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0001353	increased aggression to other mice	"when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0001357	increased aggression to humans	"when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward humans" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0001674	abnormal triploblastic development	"abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0001683	absent mesoderm	"missing or failure to differentiate the middle primary germ layer " [J:40594]	Show Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified Allelic Composition: Eomes^tm1Rob/Eomes^tm1.1Rob,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA
MP:0001685	abnormal endoderm development	"failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Eomes^tm1Rob/Eomes^tm1.1Rob,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA
MP:0001693	failure of primitive streak formation	"inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0001696	failure to gastrulate	"inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]	Show Allelic Composition: Zap70^tm2.1Weis/Zap70^tm2.1Weis,Tg(DO11.10)10Dlo/? Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6
MP:0001706	abnormal left-right axis patterning	"anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0001714	absent trophoblast cells	"missing cells of the extraembryonic cell layer that contribute to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]	Show Allelic Composition: Six1^tm1Mair/Six1^tm1Mair,Six4^tm1Mair/Six4^tm1Mair Genetic Background: either: 129/Sv-Six1^tm1Mair Six4^tm1Mair or B6N.129-Six1^tm1Mair Six4^tm1Mair
MP:0001728	failure of implantation	"inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]	Show Allelic Composition: Six1^tm1Mair/Six1^tm1Mair,Six4^tm1Mair/Six4^tm1Mair Genetic Background: either: 129/Sv-Six1^tm1Mair Six4^tm1Mair or B6N.129-Six1^tm1Mair Six4^tm1Mair
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Six1^tm1Mair/Six1^tm1Mair,Six4^tm1Mair/Six4^tm1Mair Genetic Background: either: 129/Sv-Six1^tm1Mair Six4^tm1Mair or B6N.129-Six1^tm1Mair Six4^tm1Mair Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 * SJL
MP:0002080	prenatal lethality	"death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes^tm1.1Rob Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA
MP:0002084	abnormal developmental patterning	"abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hfe^tm1Wsr/Hfe^tm1Wsr,Tg(Alb1-cre)7Gsc/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hfe^tm1Wsr/Hfe^tm1Wsr,Tg(Alb1-cre)7Gsc/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Wnt3^tm1Brd/Wnt3⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm4Rob/Nodal^tm4Rob Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA Allelic Composition: Eomes^tm1Whk/Eomes^tm1Whk Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J Allelic Composition: Eomes^{tm1.1(cre/ERT2)Sjar}/Eomes⁺ Genetic Background: involves: 129S/SvEv
MP:0002231	abnormal primitive streak morphology	"anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA Allelic Composition: Eomes^tm1Rob/Eomes^tm2.1Rob,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA
MP:0002418	increased susceptibility to viral infection	"greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0002442	abnormal leukocyte physiology	"abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0002741	small olfactory bulb	"reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0002825	abnormal notochord	"malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0002961	abnormal axon guidance	"defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0003085	abnormal egg cylinder morphology	"anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified
MP:0003156	abnormal lymphocyte migration/homing	"altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]	Show Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 * SJL
MP:0003202	abnormal neuron apoptosis	"change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0003886	abnormal embryonic epiblast morphology	"anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Eomes^tm1Rob/Eomes^tm1.1Rob,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA Allelic Composition: Eomes^tm1Rob/Eomes^tm2.1Rob,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Entpd1^{tm1b(EUCOMM)Wtsi}/Entpd1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Entpd1^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0003988	disorganized embryonic tissue	"a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0004066	abnormal Henson s node morphology	"malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0004948	abnormal neuronal precursor proliferation	"any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0005031	abnormal trophoblast	"malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified Allelic Composition: Eomes^tm1.1Rob/Eomes^tm1.1Rob Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA
MP:0006254	thin cerebral cortex	"decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0006309	decreased retinal ganglion cell number	"reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Nf1^tm1Tyj/Nf1⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0008037	abnormal T cell morphology	"any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0008040	decreased NK T cell number	"reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified
MP:0008045	decreased NK cell number	"reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified Allelic Composition: Eomes^tm1Apr/Eomes⁺,Tbx21^tm1Srnr/Tbx21^tm1Srnr Genetic Background: involves: C57BL/6
MP:0008050	decreased memory T cell number	"reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified Allelic Composition: Eomes^tm1Apr/Eomes⁺,Tbx21^tm1Srnr/Tbx21^tm1Srnr Genetic Background: involves: C57BL/6 Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tbx21^tm1Srnr/Tbx21^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: C57BL/6 * DBA/2 * SJL
MP:0008053	abnormal NK cell differentiation	"atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Lhx1^tm1Bhr/Lhx1^tm2.1Rob,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA Allelic Composition: Eomes^tm1.1Twa/?,Il15^tm1Imx/Il15^tm1Imx Genetic Background: involves: C57BL/6 * C57BL/6N Allelic Composition: Eomes^tm1.1Twa/?,Tg(Itgax-TGFBR2)1Flv/? Genetic Background: involves: C3H * C57BL/6 * C57BL/6N Allelic Composition: Eomes^tm1.1Twa/?,Tg(CD2-Tbx21)#Staka/? Genetic Background: involves: C57BL/6N
MP:0008056	abnormal retinal ganglion cell morphology	"any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Nf1^tm1Tyj/Nf1⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tbx21^tm1Srnr/Tbx21^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
MP:0008080	abnormal CD8-positive T cell differentiation	"atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tbx21^tm1Srnr/Tbx21^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0008227	absent anterior commissure	"absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0008507	thin retinal ganglion layer	"reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Nf1^tm1Tyj/Nf1⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
MP:0008530	abnormal rostral-caudal patterning of the somites	"anomaly in the developmental pattern of the somites along the axis that runs from the head to the caudal region of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Eomes^tm1Apr/Eomes⁺,Tbx21^tm1Srnr/Tbx21^tm1Srnr Genetic Background: involves: C57BL/6 Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
MP:0008681	increased interleukin-17 secretion	"increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]	Show Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
MP:0008699	increased interleukin-4 secretion	"increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]	Show Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
MP:0008751	abnormal interleukin level	"deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tbx21^tm1Srnr/Tbx21^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0009331	absent primitive node	"absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified
MP:0009850	embryonic lethality between implantation and placentation	"death anytime after implantation but before placentation (Mus: E4.5 to less than E9)" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eomes^{tm1.1(cre/ERT2)Sjar}/Eomes⁺ Genetic Background: involves: 129S/SvEv
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Entpd1^{tm1b(EUCOMM)Wtsi}/Entpd1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Entpd1^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Tbx4^tm1.1Kng/Tbx4⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Entpd1^{tm1b(EUCOMM)Wtsi}/Entpd1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Entpd1^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0011094	complete embryonic lethality before implantation	"death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]	Show Allelic Composition: Six1^tm1Mair/Six1^tm1Mair,Six4^tm1Mair/Six4^tm1Mair Genetic Background: either: 129/Sv-Six1^tm1Mair Six4^tm1Mair or B6N.129-Six1^tm1Mair Six4^tm1Mair
MP:0011095	complete embryonic lethality between implantation and placentation	"death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]	Show Allelic Composition: Zap70^tm2.1Weis/Zap70^tm2.1Weis,Tg(DO11.10)10Dlo/? Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6
MP:0011096	complete embryonic lethality before somite formation	"death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified Allelic Composition: Eomes^tm1.1Rob/Eomes^tm1.1Rob Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Entpd1^{tm1b(EUCOMM)Wtsi}/Entpd1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Entpd1^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0011186	abnormal visceral endoderm morphology	"any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]	Show Allelic Composition: Eomes^tm1Rob/Eomes^tm1.1Rob,Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA
MP:0011199	abnormal amniotic cavity morphology	"any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0011255	abnormal anterior visceral endoderm cell migration	"any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:csmith, PMID:17078044]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0012102	absent trophectoderm	"absence of the outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo s means of nutrition" [MGI:anna]	Show Allelic Composition: Six1^tm1Mair/Six1^tm1Mair,Six4^tm1Mair/Six4^tm1Mair Genetic Background: either: 129/Sv-Six1^tm1Mair Six4^tm1Mair or B6N.129-Six1^tm1Mair Six4^tm1Mair
MP:0012135	embryonic-extraembryonic boundary constriction	"an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0012156	rostral-caudal axis duplication	"partial or complete duplication of rostral-caudal axis structures" [MGI:anna]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0012157	rostral body truncation	"rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA Allelic Composition: Eomes^tm1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA
MP:0012181	increased somite number	"increase in the average number of somites formed relative to littermates or other controls" [MGI:anna]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0012675	enlarged floor plate	"increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [MGI:anna]	Show Allelic Composition: Eomes^tm1.1Rob/Eomes⁺,Nodal^tm1Rob/Nodal⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
MP:0012685	abnormal primitive streak elongation	"any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]	Show Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified
MP:0012739	abnormal anterior primitive streak morphology	"any structural anomaly of the anterior region of the vertebrate primitive streak which gives rise to the axial and paraxial mesoderm, the definitive endoderm, the primitive groove, and the primitive node" [MGI:anna]	Show Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified
MP:0013292	embryonic lethality prior to organogenesis	"death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]	Show Allelic Composition: Entpd1^{tm1b(EUCOMM)Wtsi}/Entpd1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Entpd1^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Entpd1^{tm1b(EUCOMM)Wtsi}/Entpd1^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Entpd1^{tm1b(EUCOMM)Wtsi}/Ieg
MP:0030005	increased retinal apoptosis	"increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a⁺,Nf1^tm1Tyj/Nf1⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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