ENSMUSG00000026572


Mus musculus

Features
Gene ID: ENSMUSG00000026572
  
Biological name :Tbx19
  
Synonyms : Q99ME7 / T-box transcription factor TBX19 / Tbx19
  
Possible biological names infered from orthology : O60806 / T-box 19
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H2.2
Gene start: 165137855
Gene end: 165160773
  
Corresponding Affymetrix probe sets: 10359701 (MoGene1.0st)   1422085_at (Mouse Genome 430 2.0 Array)   1422086_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027859
Ensembl peptide - ENSMUSP00000123909
NCBI entrez gene - 83993     See in Manteia.
MGI - MGI:1891158
RefSeq - NM_032005
RefSeq - XM_006497043
RefSeq Peptide - NP_114394
swissprot - F6USC6
swissprot - Q99ME7
Ensembl - ENSMUSG00000026572
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbx19ENSDARG00000079187Danio rerio
 TBX19ENSGALG00000015244Gallus gallus
 TBX19ENSG00000143178Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
T / P20293 / brachyury, T-box transcription factor T / TBXT* / O15178* / T-box transcription factor T*ENSMUSG0000006232757
Mga / A2AWL7 / MAX-associated protein / Q8IWI9* / MGA, MAX dimerization protein*ENSMUSG0000003394333
Tbx21 / Q9JKD8 / T-box transcription factor TBX21 / Q9UL17* / T-box 21*ENSMUSG0000000144428
Tbr1 / Q64336 / T-box brain protein 1 / Q16650* / T-box, brain 1*ENSMUSG0000003503328
Eomes / O54839 / Eomesodermin homolog / O95936* / eomesodermin*ENSMUSG0000003244627


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR002070  Transcription factor, Brachyury
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site
 IPR036960  T-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045595 regulation of cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0000640 adrenal gland hypoplasia "underdeveloped endocrine glands located above the kidney and responsible for hormone and epinephrine secretion, resulting from reduced numbers of cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0000676 abnormal water content "more or less than the normal total amount of water retained in the body" [il:Ira Lu, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0002664 decreased circulating adrenocorticotropin level "decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0008237 abnormal ventral coat pigmentation "irregular or unusual pigmentation of ventrum hair in relation to control animals" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0008341 decreased corticotroph cell number "reduced number of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [CL:0000467, MESH:A06.407.747.608.500]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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