Manteia

ENSMUSG00000001444

Mus musculus

Features

Gene ID:	ENSMUSG00000001444

Biological name :	Tbx21

Synonyms :	Q9JKD8 / T-box transcription factor TBX21 / Tbx21

Possible biological names infered from orthology :	Q9UL17 / T-box 21

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	D
Gene start:	97098071
Gene end:	97115331

Corresponding Affymetrix probe sets:	10390328 (MoGene1.0st) 1449361_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000001484 NCBI entrez gene - 57765 See in Manteia. MGI - MGI:1888984 RefSeq - NM_019507 RefSeq Peptide - NP_062380 swissprot - Q9JKD8 Ensembl - ENSMUSG00000001444

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tbx21	ENSDARG00000004473	Danio rerio
TBX21	ENSG00000073861	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Eomes / O54839 / Eomesodermin homolog / O95936* / eomesodermin*	ENSMUSG00000032446	44
Tbr1 / Q64336 / T-box brain protein 1 / Q16650* / T-box, brain 1*	ENSMUSG00000035033	40
Mga / A2AWL7 / MAX-associated protein / Q8IWI9* / MGA, MAX dimerization protein*	ENSMUSG00000033943	27
T / P20293 / brachyury, T-box transcription factor T / TBXT* / O15178* / T-box transcription factor T*	ENSMUSG00000062327	25
Tbx19 / Q99ME7 / T-box transcription factor TBX19 / O60806* / T-box 19*	ENSMUSG00000026572	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR001699	Transcription factor, T-box
IPR008967	p53-like transcription factor, DNA-binding
IPR018186	Transcription factor, T-box, conserved site
IPR036960	T-box superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0009615	response to virus	IEA
biological_process	GO:0030217	T cell differentiation	IMP
biological_process	GO:0032703	negative regulation of interleukin-2 production	IMP
biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP
biological_process	GO:0045580	regulation of T cell differentiation	IMP
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IEA
biological_process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IMP
biological_process	GO:0050776	regulation of immune response	IMP
biological_process	GO:0071310	cellular response to organic substance	IDA
biological_process	GO:0072676	lymphocyte migration	IEA
biological_process	GO:2000320	negative regulation of T-helper 17 cell differentiation	IDA
biological_process	GO:2000329	negative regulation of T-helper 17 cell lineage commitment	IMP
biological_process	GO:2000552	negative regulation of T-helper 2 cell cytokine production	IMP
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0043025	neuronal cell body	IDA
molecular_function	GO:0003677	DNA binding	IMP
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0044212	transcription regulatory region DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0000488	abnormal intestinal epithelium morphology	"anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Wnk1)Clhu}/Gt(ROSA)26Sor⁺,Kdr^tm1(cre)Sato/Kdr⁺,Wnk1^{Gt(OST38262)Lex}/Wnk1^{Gt(OST38262)Lex} Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd
MP:0000493	rectal prolapse	"downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac
MP:0001272	increased metastatic potential		Show Allelic Composition: Kcnq1^vtg-4J/Kcnq1^vtg-4J Genetic Background: B6.NOD-Kcnq1^vtg-4J/J
MP:0001663	abnormal digestive system physiology	"altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Wnk1)Clhu}/Gt(ROSA)26Sor⁺,Kdr^tm1(cre)Sato/Kdr⁺,Wnk1^{Gt(OST38262)Lex}/Wnk1^{Gt(OST38262)Lex} Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0001805	decreased IgG	"less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
MP:0001952	increased airway responsiveness	"more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas Allelic Composition: Tbx21^tm1Glm/Tbx21⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav Genetic Background: involves: 129P2/OlaHsd
MP:0002132	abnormal respiratory system morphology	"anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas Allelic Composition: Tbx21^tm1Glm/Tbx21⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002405	respiratory system inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas
MP:0002418	increased susceptibility to viral infection	"greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Tbx21^tm2Srnr/Tbx21^tm2Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129 * C57BL/6 * DBA/2 Allelic Composition: Tbx21^tm2Srnr/Tbx21⁺,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0002433	abnormal T helper 1 morphology/development	"anomalous structure, formation, or numbers of the subset of helper T cells that enhance cell-mediated immune responses. These cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Eomes^tm1Apr/Eomes⁺,Tbx21^tm1Srnr/Tbx21^tm1Srnr Genetic Background: involves: C57BL/6
MP:0002436	abnormal cytotoxic T cell morphology/development	"anomalous structure, formation, or numbers of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas
MP:0002442	abnormal leukocyte physiology	"abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0002490	abnormal circulating immunoglobulin concentration	"deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
MP:0002816	colitis	"local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Insm1^tm1Cbm/Insm1^tm1Cbm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003080	competent NK cell cytolysis	"ability of these cells to destroy or dissolve targeted cells" [RGD:Rat Genome Database submission]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas
MP:0003156	abnormal lymphocyte migration/homing	"altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]	Show Allelic Composition: Stat6^tm1Gru/Stat6^tm1Gru Genetic Background: involves: 129S2/SvPas Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
MP:0003304	large intestinal inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Insm1^tm1Cbm/Insm1^tm1Cbm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004842	abnormal large intestine crypts of Lieberkuhn morphology	"any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac
MP:0005027	increased susceptibility to parasitic infection	"greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas
MP:0005070	defective NK cell cytolysis	"impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
MP:0005340	altered susceptibility to atherosclerosis	"a change in the likelihood that an organism will develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
MP:0005463	abnormal CD4+ T cell physiology	"anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Insm1^tm1Cbm/Insm1^tm1Cbm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006082	CNS inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]	Show Allelic Composition: Insm1^tm1Cbm/Insm1^tm1Cbm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008037	abnormal T cell morphology	"any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0008040	decreased NK T cell number	"reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified Allelic Composition: Tbx21^tm1Srnr/Tbx21^tm1Srnr Genetic Background: involves: C57BL/6
MP:0008041	absent NK T cells	"absence of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Tbx21^tm1Srnr/Tbx21^tm1Srnr Genetic Background: involves: C57BL/6 Allelic Composition: Tbx21^duane/Tbx21^duane Genetic Background: C57BL/6-Tbx21^duane
MP:0008044	increased NK cell number	"greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Tbx21^duane/Tbx21^duane Genetic Background: C57BL/6-Tbx21^duane
MP:0008045	decreased NK cell number	"reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Eomes^tm1Apr/Eomes^tm1Apr Genetic Background: Not Specified Allelic Composition: Tbx21^tm1Srnr/Tbx21⁺ Genetic Background: involves: C57BL/6 Allelic Composition: Tbx21^duane/Tbx21^duane Genetic Background: C57BL/6-Tbx21^duane
MP:0008050	decreased memory T cell number	"reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eomes^tm1Apr/Eomes⁺,Tbx21^tm1Srnr/Tbx21^tm1Srnr Genetic Background: involves: C57BL/6 Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tbx21^tm1Srnr/Tbx21^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
MP:0008053	abnormal NK cell differentiation	"atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Tbx21^duane/Tbx21^duane Genetic Background: C57BL/6-Tbx21^duane Allelic Composition: Eomes^tm1.1Twa/?,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac * C57BL/6N
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
MP:0008076	abnormal CD4-positive T cell differentiation	"atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nodal^tm1.1Mku/Nodal^tm2Mku,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129S1/Sv * C3H * C57BL/6
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tbx21^tm1Srnr/Tbx21^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL Allelic Composition: Tbx21^tm2Srnr/Tbx21^tm2Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129 * C57BL/6 * DBA/2 Allelic Composition: Tbx21^tm2Srnr/Tbx21⁺,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0008080	abnormal CD8-positive T cell differentiation	"atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tbx21^tm1Srnr/Tbx21^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0008087	decreased T helper 1 cell number	"reduced number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas Allelic Composition: Tbx21^tm1Glm/Tbx21⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0008088	abnormal T-helper 1 cell differentiation	"atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas
MP:0008090	increased T-helper 2 cell number	"greater number of the subset of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas
MP:0008537	increased susceptibility to induced colitis	"increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac Allelic Composition: Tbx21^tm2Srnr/Tbx21^tm2Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas Allelic Composition: Eomes^tm1Apr/Eomes⁺,Tbx21^tm1Srnr/Tbx21^tm1Srnr Genetic Background: involves: C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008568	abnormal interleukin secretion	"anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
MP:0008681	increased interleukin-17 secretion	"increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]	Show Allelic Composition: Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL Allelic Composition: Tbx21^tm2Srnr/Tbx21^tm2Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0008687	increased interleukin-2 secretion	"increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]	Show Allelic Composition: Tbx21^tm2Srnr/Tbx21^tm2Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129 * C57BL/6 * DBA/2
MP:0008699	increased interleukin-4 secretion	"increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]	Show Allelic Composition: Eomes^tm1.1Bflu/Eomes^tm1.1Bflu,Tbx21^tm1Glm/Tbx21^tm1Glm,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL
MP:0008713	abnormal cytokine level	"deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas Allelic Composition: Tbx21^tm1Glm/Tbx21⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac
MP:0008751	abnormal interleukin level	"deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas Allelic Composition: Tbx21^tm1Glm/Tbx21⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tbx21^tm1Srnr/Tbx21^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0008752	abnormal tumor necrosis factor level	"deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas Allelic Composition: Tbx21^tm1Glm/Tbx21⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0009219	prostate intraepithelial neoplasia	"noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq1^vtg-4J/Kcnq1^vtg-4J Genetic Background: B6.NOD-Kcnq1^vtg-4J/J
MP:0009220	prostate adenocarcinoma	"malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq1^vtg-4J/Kcnq1^vtg-4J Genetic Background: B6.NOD-Kcnq1^vtg-4J/J
MP:0010357	increased prostate gland tumor incidence	"greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq1^vtg-4J/Kcnq1^vtg-4J Genetic Background: B6.NOD-Kcnq1^vtg-4J/J
MP:0010766	abnormal NK cell physiology	"any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]	Show Allelic Composition: Lef1^tm1Rug/Lef1^tm1Rug Genetic Background: involves: 129S2/SvPas Allelic Composition: Tbx21^tm1Glm/Tbx21⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr