ENSMUSG00000035033


Mus musculus

Features
Gene ID: ENSMUSG00000035033
  
Biological name :Tbr1
  
Synonyms : Q64336 / T-box brain protein 1 / Tbr1
  
Possible biological names infered from orthology : Q16650 / T-box, brain 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C1.3
Gene start: 61802930
Gene end: 61814114
  
Corresponding Affymetrix probe sets: 10472313 (MoGene1.0st)   1416711_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099798
Ensembl peptide - ENSMUSP00000046787
NCBI entrez gene - 21375     See in Manteia.
MGI - MGI:107404
RefSeq - NM_009322
RefSeq - XM_006499098
RefSeq Peptide - NP_033348
swissprot - A2AR81
swissprot - Q64336
Ensembl - ENSMUSG00000035033
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbr1bENSDARG00000004712Danio rerio
 TBR1ENSGALG00000036378Gallus gallus
 TBR1ENSG00000136535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eomes / O54839 / Eomesodermin homolog / O95936* / eomesodermin*ENSMUSG0000003244648
Tbx21 / Q9JKD8 / T-box transcription factor TBX21 / Q9UL17* / T-box 21*ENSMUSG0000000144431
Mga / A2AWL7 / MAX-associated protein / Q8IWI9* / MGA, MAX dimerization protein*ENSMUSG0000003394322
Tbx19 / Q99ME7 / T-box transcription factor TBX19 / O60806* / T-box 19*ENSMUSG0000002657218
T / P20293 / brachyury, T-box transcription factor T / TBXT* / O15178* / T-box transcription factor T*ENSMUSG0000006232717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001699  Transcription factor, T-box
 IPR008967  p53-like transcription factor, DNA-binding
 IPR018186  Transcription factor, T-box, conserved site
 IPR032385  T-box transcription factor-associated
 IPR036960  T-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001661 conditioned taste aversion IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010092 specification of animal organ identity IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010975 regulation of neuron projection development IMP
 biological_processGO:0021764 amygdala development IMP
 biological_processGO:0021902 commitment of neuronal cell to specific neuron type in forebrain IGI
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:1902667 regulation of axon guidance IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000818 abnormal amygdala morphology "any malformation or absence of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsdm1J/Ctsdm1J
Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ctsdm1J/Ctsdm1J
Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0002969 impaired social transmission of food preference "defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues" [J:62218]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0005237 abnormal olfactory tract morphology "structural anomaly of the nervelike, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34460]
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Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005267 abnormal olfactory cortex morphology "anomalous structure of piriform cortex, part of the olfactory tract, which receives its major afferents from the olfactory bulb, and is primarily responsible for the identification of odors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83884]
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Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0009941 abnormal olfactory bulb interneuron morphology "any structural anomaly of the group of neurons residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" [PMID:18603310]
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Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009947 abnormal olfactory bulb external plexiform layer morphology "any structural anomaly of the part of the olfactory bulb, lying superior to the mitral cell layer and inferior to the glomerular layer, which is mostly neuropil composed almost entirely of mitral and tufted cell dendrites, granule cell dendrites and their synaptic inputs" [NLX:nlx_96 "NeuroLex.org"]
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Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009948 abnormal olfactory bulb glomerular layer morphology 
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Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009951 abnormal olfactory bulb mitral cell layer morphology 
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Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009954 abnormal mitral cell morphology "any structural anomaly of the large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009955 abnormal olfactory bulb tufted cell morphology "any structural anomaly of the principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala" [NLX:nifext_121 "NeuroLex.org"]
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Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010059 olfactory bulb hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0014115 cognitive inflexibility "inability to change attention or a cognitive behavior as an adaptation to the demands of external stimuli" [PMID:26112128]
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Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
Show

Allelic Composition: Tbr1tm1Jlr/Tbr1+
Genetic Background: B6.129X1-Tbr1tm1Jlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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