ENSG00000156374


Homo sapiens

Features
Gene ID: ENSG00000156374
  
Biological name :PCGF6
  
Synonyms : PCGF6 / polycomb group ring finger 6 / Q9BYE7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.33
Gene start: 103302796
Gene end: 103351134
  
Corresponding Affymetrix probe sets: 224326_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000338845
Ensembl peptide - ENSP00000358862
NCBI entrez gene - 84108     See in Manteia.
OMIM - 607816
RefSeq - NM_001011663
RefSeq - NM_032154
RefSeq Peptide - NP_001011663
RefSeq Peptide - NP_115530
swissprot - Q9BYE7
Ensembl - ENSG00000156374
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcgf6ENSDARG00000069681Danio rerio
 PCGF6ENSGALG00000008230Gallus gallus
 Pcgf6ENSMUSG00000025050Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PCGF1 / Q9BSM1 / polycomb group ring finger 1ENSG0000011528925
PCGF5 / Q86SE9 / polycomb group ring finger 5ENSG0000018062824
COMMD3-BMI1 / COMMD3-BMI1 readthroughENSG0000026989724
PCGF3 / Q3KNV8 / polycomb group ring finger 3ENSG0000018561923
PCGF2 / P35227 / polycomb group ring finger 2ENSG0000027725823
BMI1 / P35226 / BMI1 proto-oncogene, polycomb ring fingerENSG0000016828322


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0036353 histone H2A-K119 monoubiquitination IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0031519 PcG protein complex TAS
 cellular_componentGO:0035102 PRC1 complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100395 Q969R5 / L3MBTL2 / L3MBTL2, polycomb repressive complex 1 subunit  / complex
 ENSG00000125952 MAX / P61244 / MYC associated factor X  / reaction / complex
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / reaction / complex
 ENSG00000122565 CBX3 / Q13185 / chromobox 3  / complex / reaction
 ENSG00000174197 MGA / Q8IWI9 / MGA, MAX dimerization protein  / reaction / complex
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / reaction / complex
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / reaction / complex
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex / reaction
 ENSG00000015153 YAF2 / Q8IY57 / YY1 associated factor 2  / complex
 ENSG00000121481 RNF2 / Q99496 / ring finger protein 2  / complex
 ENSG00000204227 RING1 / Q06587 / ring finger protein 1  / complex






 

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