ENSG00000277258


Homo sapiens

Features
Gene ID: ENSG00000277258
  
Biological name :PCGF2
  
Synonyms : P35227 / PCGF2 / polycomb group ring finger 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q12
Gene start: 38733897
Gene end: 38749817
  
Corresponding Affymetrix probe sets: 203792_x_at (Human Genome U133 Plus 2.0 Array)   203793_x_at (Human Genome U133 Plus 2.0 Array)   213551_x_at (Human Genome U133 Plus 2.0 Array)   214239_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482063
Ensembl peptide - ENSP00000482815
Ensembl peptide - ENSP00000484721
Ensembl peptide - ENSP00000484201
Ensembl peptide - ENSP00000483741
Ensembl peptide - ENSP00000478970
Ensembl peptide - ENSP00000481656
NCBI entrez gene - 7703     See in Manteia.
OMIM - 600346
RefSeq - XM_005257640
RefSeq - XM_017025016
RefSeq - XM_005257642
RefSeq - XM_005257641
RefSeq - NM_007144
RefSeq Peptide - NP_009075
swissprot - P35227
swissprot - A0A087X259
swissprot - J3KT13
swissprot - A0A024R1V6
swissprot - A0A087X0Y6
Ensembl - ENSG00000277258
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040501Gallus gallus
 PCGF2ENSGALG00000018815Gallus gallus
 Pcgf2ENSMUSG00000018537Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
COMMD3-BMI1 / COMMD3-BMI1 readthroughENSG0000026989762
BMI1 / P35226 / BMI1 proto-oncogene, polycomb ring fingerENSG0000016828362
PCGF1 / Q9BSM1 / polycomb group ring finger 1ENSG0000011528924
PCGF3 / Q3KNV8 / polycomb group ring finger 3ENSG0000018561924
PCGF5 / Q86SE9 / polycomb group ring finger 5ENSG0000018062823
PCGF6 / Q9BYE7 / polycomb group ring finger 6ENSG0000015637423


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR032443  RAWUL domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0036353 histone H2A-K119 monoubiquitination IMP
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0001739 sex chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0031519 PcG protein complex IDA
 cellular_componentGO:0035102 PRC1 complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163602 RYBP / Q8N488 / RING1 and YY1 binding protein  / complex
 ENSG00000173889 PHC3 / Q8NDX5 / polyhomeotic homolog 3  / complex
 ENSG00000111752 PHC1 / P78364 / polyhomeotic homolog 1  / complex
 ENSG00000204227 RING1 / Q06587 / ring finger protein 1  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr