ENSG00000163602


Homo sapiens

Features
Gene ID: ENSG00000163602
  
Biological name :RYBP
  
Synonyms : Q8N488 / RING1 and YY1 binding protein / RYBP
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p13
Gene start: 72371825
Gene end: 72446621
  
Corresponding Affymetrix probe sets: 201844_s_at (Human Genome U133 Plus 2.0 Array)   201845_s_at (Human Genome U133 Plus 2.0 Array)   201846_s_at (Human Genome U133 Plus 2.0 Array)   242719_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419494
RefSeq - NM_012234
RefSeq Peptide - NP_036366
swissprot - Q8N488
Ensembl - ENSG00000163602
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rybpaENSDARG00000037773Danio rerio
 rybpbENSDARG00000053459Danio rerio
 RybpENSMUSG00000072872Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YAF2 / Q8IY57 / YY1 associated factor 2ENSG0000001515350


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR033774  Yaf2/RYBP C-terminal binding motif
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0035518 histone H2A monoubiquitination IDA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031519 PcG protein complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000173889 PHC3 / Q8NDX5 / polyhomeotic homolog 3  / complex
 ENSG00000168283 BMI1 / P35226 / BMI1 proto-oncogene, polycomb ring finger  / complex
 ENSG00000277258 PCGF2 / P35227 / polycomb group ring finger 2  / complex
 ENSG00000111752 PHC1 / P78364 / polyhomeotic homolog 1  / complex
 ENSG00000204227 RING1 / Q06587 / ring finger protein 1  / complex






 

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