ENSMUSG00000072872


Mus musculus

Features
Gene ID: ENSMUSG00000072872
  
Biological name :Rybp
  
Synonyms : Q8CCI5 / RING1 and YY1-binding protein / Rybp
  
Possible biological names infered from orthology : Q8N488
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D3
Gene start: 100228565
Gene end: 100287485
  
Corresponding Affymetrix probe sets: 10410209 (MoGene1.0st)   10546706 (MoGene1.0st)   1421111_at (Mouse Genome 430 2.0 Array)   1428219_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098677
NCBI entrez gene - 56353     See in Manteia.
MGI - MGI:1929059
RefSeq - NM_019743
RefSeq Peptide - NP_062717
swissprot - Q8CCI5
Ensembl - ENSMUSG00000072872
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rybpaENSDARG00000037773Danio rerio
 rybpbENSDARG00000053459Danio rerio
 RYBPENSG00000163602Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Yaf2 / Q99LW6 / YY1 associated factor 2 / Q8IY57*ENSMUSG0000002263451


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR033774  Yaf2/RYBP C-terminal binding motif
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0035518 histone H2A monoubiquitination IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031519 PcG protein complex IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001059 optic nerve atrophy "wasting of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tg(KRT14-Figf)1Ali/0,Vegfctm1Ali/Vegfc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0001329 retina hyperplasia "greater than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tg(KRT14-Figf)1Ali/0,Vegfctm1Ali/Vegfc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0001714 absent trophoblast cells "missing cells of the extraembryonic cell layer that contribute to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001729 impaired implantation "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005262 coloboma "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tg(KRT14-Figf)1Ali/0,Vegfctm1Ali/Vegfc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0010706 ventral rotation of lens "a circular shift toward the ventral pole in the position of the equator of the lens relative to the optic nerve exit point" [PMID:7923367]
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Allelic Composition: Tg(KRT14-Figf)1Ali/0,Vegfctm1Ali/Vegfc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0010715 coloboma of the retina "congenital defect of the retina in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(KRT14-Figf)1Ali/0,Vegfctm1Ali/Vegfc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0010717 coloboma of the optic nerve "congenital defect of the optic nerve in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(KRT14-Figf)1Ali/0,Vegfctm1Ali/Vegfc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011193 embryonic epiblast cell degeneration "a retrogressive impairment of function or destruction of the cells comprising the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012102 absent trophectoderm "absence of the outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo s means of nutrition" [MGI:anna]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018537 Pcgf2 / P23798 / Polycomb group RING finger protein 2 / P35227* / polycomb group ring finger 2*  / complex
 ENSMUSG00000024325 Ring1 / O35730 / E3 ubiquitin-protein ligase RING1 / Q06587* / ring finger protein 1*  / complex
 ENSMUSG00000026739 Bmi1 / P25916 / Polycomb complex protein BMI-1 / P35226* / COMMD3-BMI1* / COMMD3-BMI1 readthrough* / BMI1 proto-oncogene, polycomb ring finger*  / complex
 ENSMUSG00000037652 Phc3 / Q8CHP6 / Polyhomeotic-like protein 3 / Q8NDX5* / polyhomeotic homolog 3*  / complex






 

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