ENSG00000125482


Homo sapiens

Features
Gene ID: ENSG00000125482
  
Biological name :TTF1
  
Synonyms : Q15361 / transcription termination factor 1 / TTF1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q34.13
Gene start: 132375548
Gene end: 132406851
  
Corresponding Affymetrix probe sets: 204771_s_at (Human Genome U133 Plus 2.0 Array)   204772_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000333920
Ensembl peptide - ENSP00000481441
NCBI entrez gene - 7270     See in Manteia.
OMIM - 600777
RefSeq - XM_017015105
RefSeq - NM_001205296
RefSeq - NM_007344
RefSeq - XM_006717273
RefSeq Peptide - NP_001192225
RefSeq Peptide - NP_031370
swissprot - A0A087WY09
swissprot - Q15361
swissprot - A0A024R8C1
Ensembl - ENSG00000125482
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-376l24.2ENSDARG00000092508Danio rerio
 si:ch73-376l24.3ENSDARG00000094043Danio rerio
 si:ch73-376l24.4ENSDARG00000093403Danio rerio
 si:ch73-376l24.6ENSDARG00000093999Danio rerio
 si:ch73-37h15.2ENSDARG00000094107Danio rerio
 ttf1ENSDARG00000091967Danio rerio
 ENSGALG00000027242Gallus gallus
 Ttf1ENSMUSG00000026803Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DMTF1 / Q9Y222 / cyclin D binding myb like transcription factor 1ENSG0000013516412


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR017877  Myb-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006353 DNA-templated transcription, termination NAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006363 termination of RNA polymerase I transcription TAS
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0044267 cellular protein metabolic process TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
Surfactant metabolism
Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Termination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108312 UBTF / P17480 / upstream binding transcription factor, RNA polymerase I  / complex / reaction
 ENSG00000168878 SFTPB / P07988 / surfactant protein B  / complex
 ENSG00000133773 CCDC59 / Q9P031 / coiled-coil domain containing 59  / complex / reaction
 ENSG00000225830 ERCC6 / P0DP91 / Q03468 / Q8N328 / ERCC excision repair 6, chromatin remodeling factor  / complex / reaction
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / complex / reaction
 ENSG00000177469 CAVIN1 / Q6NZI2 / caveolae associated protein 1  / complex / reaction






 

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