ENSG00000105325


Homo sapiens

Features
Gene ID: ENSG00000105325
  
Biological name :FZR1
  
Synonyms : fizzy and cell division cycle 20 related 1 / FZR1 / Q9UM11
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 3506273
Gene end: 3538330
  
Corresponding Affymetrix probe sets: 209414_at (Human Genome U133 Plus 2.0 Array)   209415_at (Human Genome U133 Plus 2.0 Array)   209416_s_at (Human Genome U133 Plus 2.0 Array)   211865_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000321800
Ensembl peptide - ENSP00000378529
Ensembl peptide - ENSP00000410369
Ensembl peptide - ENSP00000467967
NCBI entrez gene - 51343     See in Manteia.
OMIM - 603619
RefSeq - XM_017026863
RefSeq - NM_001136197
RefSeq - NM_001136198
RefSeq - NM_016263
RefSeq - XM_005259573
RefSeq Peptide - NP_001129670
RefSeq Peptide - NP_057347
RefSeq Peptide - NP_001129669
swissprot - Q9UM11
swissprot - K7EQT1
Ensembl - ENSG00000105325
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzr1aENSDARG00000015254Danio rerio
 FZR1ENSGALG00000002085Gallus gallus
 Fzr1ENSMUSG00000020235Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDC20 / Q12834 / cell division cycle 20ENSG0000011739936
CDC20B / Q86Y33 / cell division cycle 20BENSG0000016428724


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR033010  The WD repeat Cdc20/Fizzy family
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IDA
 biological_processGO:0040020 regulation of meiotic nuclear division IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IGI
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0070306 lens fiber cell differentiation IEA
 biological_processGO:0070979 protein K11-linked ubiquitination TAS
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IDA
 biological_processGO:0090344 negative regulation of cell aging IEA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005680 anaphase-promoting complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031965 nuclear membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0010997 anaphase-promoting complex binding IEA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IEA


Pathways (from Reactome)
Pathway description
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A:Cdk2-associated events at S phase entry
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112029 FBXO5 / Q9UKT4 / F-box protein 5  / complex / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / reaction / complex
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / reaction / complex
 ENSG00000145604 SKP2 / Q13309 / S-phase kinase associated protein 2  / complex
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / complex / reaction
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / reaction / complex
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / reaction / complex






 

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