ENSDARG00000015254


Danio rerio

Features
Gene ID: ENSDARG00000015254
  
Biological name :fzr1a
  
Synonyms : fizzy/cell division cycle 20 related 1a / fzr1a
  
Possible biological names infered from orthology : fizzy and cell division cycle 20 related 1 / Fizzy-related protein homolog / FZR1 / Q9R1K5 / Q9UM11
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 20863025
Gene end: 20876562
  
Corresponding Affymetrix probe sets: Dr.1107.1.S1_at (Zebrafish Array)   NM_200253_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000117175
Ensembl peptide - ENSDARP00000156177
Ensembl peptide - ENSDARP00000003004
NCBI entrez gene - 393223     See in Manteia.
RefSeq - NM_200253
RefSeq Peptide - NP_956547
swissprot - B0S4Z7
swissprot - Q7ZUP9
ZFIN ID - ZDB-GENE-040426-712
Ensembl - ENSDARG00000015254
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FZR1ENSGALG00000002085Gallus gallus
 FZR1ENSG00000105325Homo sapiens
 Fzr1ENSMUSG00000020235Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fzr1b / fizzy/cell division cycle 20 related 1bENSDARG0000002281077
cdc20 / cell division cycle 20 homolog / Q12834* / Q9JJ66* / Cell division cycle * / cell division cycle 20*ENSDARG0000010074134


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR033010  The WD repeat Cdc20/Fizzy family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0051301 cell division IEA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IEA
 molecular_functionGO:0010997 anaphase-promoting complex binding IEA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IEA


Pathways (from Reactome)
Pathway description
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A:Cdk2-associated events at S phase entry
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens nucleus circular , abnormal
lens nucleus mislocalised anteriorly , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex
 ENSDARG00000004937 skp2 / S-phase kinase-associated protein 2, E3 ubiquitin protein ligase / Q9Z0Z3* / Q13309* / S-phase kinase associated protein 2* / S-phase kinase-associated protein 2 (p45)*  / complex
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / complex / reaction
 ENSDARG00000058471 plk1 / polo-like kinase 1 (Drosophila) / P53350* / Q07832* / polo like kinase 1*  / reaction
 ENSDARG00000087554 cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*  / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex






 

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