ENSGALG00000002085


Gallus gallus

Features
Gene ID: ENSGALG00000002085
  
Biological name :FZR1
  
Synonyms : fizzy-related protein homolog / FZR1
  
Possible biological names infered from orthology : fizzy and cell division cycle 20 related 1 / Q9R1K5 / Q9UM11
  
Species: Gallus gallus
  
Chr. number: 28
Strand: -1
Band:
Gene start: 1059696
Gene end: 1073878
  
Corresponding Affymetrix probe sets: Gga.913.1.S1_at (Chicken Array)   Gga.913.1.S1_s_at (Chicken Array)   Gga.914.1.S1_a_at (Chicken Array)   Gga.914.2.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000060546
Ensembl peptide - ENSGALP00000003246
Ensembl peptide - ENSGALP00000034923
NCBI entrez gene - 395297     See in Manteia.
RefSeq - XM_015299664
RefSeq - NM_001278090
RefSeq Peptide - NP_001265019
swissprot - H9L1Y1
swissprot - A0A1L1RP42
swissprot - H9KZ18
Ensembl - ENSGALG00000002085
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzr1aENSDARG00000015254Danio rerio
 FZR1ENSG00000105325Homo sapiens
 Fzr1ENSMUSG00000020235Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDC20 / cell division cycle 20 / Q12834* / Q9JJ66* / Cell division cycle *ENSGALG0000000997136
CDC20B / cell division cycle 20B / Q86Y33*ENSGALG0000004618823


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR033010  The WD repeat Cdc20/Fizzy family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IEA
 biological_processGO:0040020 regulation of meiotic nuclear division IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0070306 lens fiber cell differentiation IEA
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IEA
 biological_processGO:0090344 negative regulation of cell aging IEA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005680 anaphase-promoting complex IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0010997 anaphase-promoting complex binding IEA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IEA


Pathways (from Reactome)
Pathway description
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A:Cdk2-associated events at S phase entry
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSGALG00000006110 PLK1 / serine/threonine-protein kinase PLK1 / P53350* / Q07832* / polo like kinase 1*  / reaction






 

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