ENSG00000112029


Homo sapiens

Features
Gene ID: ENSG00000112029
  
Biological name :FBXO5
  
Synonyms : F-box protein 5 / FBXO5 / Q9UKT4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q25.2
Gene start: 152970519
Gene end: 152983579
  
Corresponding Affymetrix probe sets: 218875_s_at (Human Genome U133 Plus 2.0 Array)   234863_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000229758
Ensembl peptide - ENSP00000356210
NCBI entrez gene - 26271     See in Manteia.
OMIM - 606013
RefSeq - NM_001142522
RefSeq - NM_012177
RefSeq Peptide - NP_001135994
RefSeq Peptide - NP_036309
swissprot - Q9UKT4
Ensembl - ENSG00000112029
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxo5ENSDARG00000039020Danio rerio
 FBXO5ENSGALG00000013607Gallus gallus
 Fbxo5ENSMUSG00000019773Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FBXO43 / Q4G163 / F-box protein 43ENSG0000015650929


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007057 spindle assembly involved in female meiosis I IEA
 biological_processGO:0007088 regulation of mitotic nuclear division IBA
 biological_processGO:0007346 regulation of mitotic cell cycle ISS
 biological_processGO:0016050 vesicle organization IEA
 biological_processGO:0040020 regulation of meiotic nuclear division IEA
 biological_processGO:0045835 negative regulation of meiotic nuclear division IBA
 biological_processGO:0046785 microtubule polymerization IEA
 biological_processGO:0051225 spindle assembly IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle IDA
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990948 ubiquitin ligase inhibitor activity IDA


Pathways (from Reactome)
Pathway description
SCF-beta-TrCP mediated degradation of Emi1
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
Activation of E2F1 target genes at G1/S
Mitotic Metaphase/Anaphase Transition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117399 CDC20 / Q12834 / cell division cycle 20  / complex / reaction
 ENSG00000105325 FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1  / complex / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / reaction / complex
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex / reaction






 

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