ENSMUSG00000019773


Mus musculus

Features
Gene ID: ENSMUSG00000019773
  
Biological name :Fbxo5
  
Synonyms : F-box only protein 5 / Fbxo5 / Q7TSG3
  
Possible biological names infered from orthology : F-box protein 5 / Q9UKT4
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A1
Gene start: 5799160
Gene end: 5805600
  
Corresponding Affymetrix probe sets: 10361375 (MoGene1.0st)   1429499_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019907
NCBI entrez gene - 67141     See in Manteia.
MGI - MGI:1914391
RefSeq - NM_025995
RefSeq Peptide - NP_080271
swissprot - Q7TSG3
Ensembl - ENSMUSG00000019773
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxo5ENSDARG00000039020Danio rerio
 FBXO5ENSGALG00000013607Gallus gallus
 FBXO5ENSG00000112029Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fbxo43 / F-box protein 43 / Q4G163*ENSMUSG0000004823027


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007057 spindle assembly involved in female meiosis I IDA
 biological_processGO:0007088 regulation of mitotic nuclear division IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0016050 vesicle organization IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0040020 regulation of meiotic nuclear division IDA
 biological_processGO:0045835 negative regulation of meiotic nuclear division IDA
 biological_processGO:0046785 microtubule polymerization IDA
 biological_processGO:0051225 spindle assembly IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle IEA
 biological_processGO:0051442 obsolete negative regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle ISO
 biological_processGO:0060903 positive regulation of meiosis I ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990948 ubiquitin ligase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
SCF-beta-TrCP mediated degradation of Emi1
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of Emi1
Mitotic Metaphase/Anaphase Transition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Cnbpm1Hrb/Cnbp+
Genetic Background: B6.129S4-Cnbpm1Hrb

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006398 Cdc20 / Q9JJ66 / Cell division cycle / Q12834* / cell division cycle 20*  / complex / reaction
 ENSMUSG00000020235 Fzr1 / Q9R1K5 / Fizzy-related protein homolog / Q9UM11* / fizzy and cell division cycle 20 related 1*  / reaction / complex
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / reaction
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / complex / reaction






 

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