ENSG00000170364


Homo sapiens

Features
Gene ID: ENSG00000170364
  
Biological name :SETMAR
  
Synonyms : Q53H47 / SET domain and mariner transposase fusion gene / SETMAR
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p26.1
Gene start: 4303304
Gene end: 4317567
  
Corresponding Affymetrix probe sets: 1554059_at (Human Genome U133 Plus 2.0 Array)   1554060_s_at (Human Genome U133 Plus 2.0 Array)   206554_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403000
Ensembl peptide - ENSP00000397463
Ensembl peptide - ENSP00000403145
Ensembl peptide - ENSP00000369673
Ensembl peptide - ENSP00000373354
Ensembl peptide - ENSP00000393044
NCBI entrez gene - 6419     See in Manteia.
OMIM - 609834
RefSeq - XM_006713294
RefSeq - NM_001243723
RefSeq - NM_001276325
RefSeq - NM_001320676
RefSeq - NM_001320677
RefSeq - NM_001320678
RefSeq - NM_006515
RefSeq - XM_006713292
RefSeq Peptide - NP_001307606
RefSeq Peptide - NP_001307607
RefSeq Peptide - NP_006506
RefSeq Peptide - NP_001230652
RefSeq Peptide - NP_001263254
RefSeq Peptide - NP_001307605
swissprot - Q53H47
swissprot - F8WB33
swissprot - F8WEU1
swissprot - B9ZVV8
Ensembl - ENSG00000170364
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 setmarENSDARG00000074836Danio rerio
 Q80UJ9ENSMUSG00000034639Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NSD1 / Q96L73 / nuclear receptor binding SET domain protein 1ENSG0000016567116
SETD2 / Q9BYW2 / SET domain containing 2ENSG0000018155514
ASH1L / Q9NR48 / ASH1 like histone lysine methyltransferaseENSG0000011653914
Q9H5I1 / SUV39H2 / suppressor of variegation 3-9 homolog 2ENSG0000015245513
O43463 / SUV39H1 / suppressor of variegation 3-9 homolog 1ENSG0000010194513
EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1ENSG0000018109012
Q15047 / SETDB1 / SET domain bifurcated 1ENSG0000014337912
EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2ENSG0000020437111
Q96T68 / SETDB2 / SET domain bifurcated 2ENSG0000013616911
NSD2 / O96028 / nuclear receptor binding SET domain protein 2ENSG0000010968511
NSD3 / Q9BZ95 / nuclear receptor binding SET domain protein 3ENSG0000014754810
EZH1 / Q92800 / enhancer of zeste 1 polycomb repressive complex 2 subunitENSG000001087999
EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunitENSG000001064628
Q9Y6X0 / SETBP1 / SET binding protein 1ENSG000001522178


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR001888  Transposase, type 1
 IPR003616  Post-SET domain
 IPR007728  Pre-SET domain
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000729 DNA double-strand break processing IDA
 biological_processGO:0000737 DNA catabolic process, endonucleolytic IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0010452 histone H3-K36 methylation IMP
 biological_processGO:0015074 DNA integration IMP
 biological_processGO:0031297 replication fork processing IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0044774 mitotic DNA integrity checkpoint IMP
 biological_processGO:0051568 histone H3-K4 methylation IDA
 biological_processGO:0071157 negative regulation of cell cycle arrest IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IMP
 biological_processGO:0097676 histone H3-K36 dimethylation IMP
 biological_processGO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity IMP
 biological_processGO:2001034 positive regulation of double-strand break repair via nonhomologous end joining IDA
 biological_processGO:2001251 negative regulation of chromosome organization IDA
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0035861 site of double-strand break IMP
 molecular_functionGO:0000014 single-stranded DNA endodeoxyribonuclease activity IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003690 double-stranded DNA binding IMP
 molecular_functionGO:0003697 single-stranded DNA binding IMP
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0044547 DNA topoisomerase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046975 histone methyltransferase activity (H3-K36 specific) IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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