ENSG00000152455


Homo sapiens

Features
Gene ID: ENSG00000152455
  
Biological name :SUV39H2
  
Synonyms : Q9H5I1 / suppressor of variegation 3-9 homolog 2 / SUV39H2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p13
Gene start: 14878820
Gene end: 14904315
  
Corresponding Affymetrix probe sets: 1554572_a_at (Human Genome U133 Plus 2.0 Array)   219262_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388218
Ensembl peptide - ENSP00000367582
Ensembl peptide - ENSP00000388968
Ensembl peptide - ENSP00000392201
Ensembl peptide - ENSP00000319208
Ensembl peptide - ENSP00000346997
Ensembl peptide - ENSP00000351046
Ensembl peptide - ENSP00000367576
NCBI entrez gene - 79723     See in Manteia.
OMIM - 606503
RefSeq - XM_017016637
RefSeq - NM_001193424
RefSeq - NM_001193425
RefSeq - NM_001193426
RefSeq - NM_001193427
RefSeq - NM_024670
RefSeq - XM_006717503
RefSeq - XM_011519662
RefSeq Peptide - NP_001180355
RefSeq Peptide - NP_001180356
RefSeq Peptide - NP_078946
RefSeq Peptide - NP_001180353
RefSeq Peptide - NP_001180354
swissprot - C9IYH9
swissprot - Q9H5I1
swissprot - C9JMB4
swissprot - G5E9A8
swissprot - H0Y306
swissprot - Q5JSS2
Ensembl - ENSG00000152455
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5F3W5ENSGALG00000013920Gallus gallus
 Suv39h2ENSMUSG00000026646Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O43463 / SUV39H1 / suppressor of variegation 3-9 homolog 1ENSG0000010194559
SETD2 / Q9BYW2 / SET domain containing 2ENSG0000018155528
EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1ENSG0000018109027
NSD1 / Q96L73 / nuclear receptor binding SET domain protein 1ENSG0000016567126
EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2ENSG0000020437125
ASH1L / Q9NR48 / ASH1 like histone lysine methyltransferaseENSG0000011653925
Q15047 / SETDB1 / SET domain bifurcated 1ENSG0000014337925
Q96T68 / SETDB2 / SET domain bifurcated 2ENSG0000013616922
NSD3 / Q9BZ95 / nuclear receptor binding SET domain protein 3ENSG0000014754822
EZH1 / Q92800 / enhancer of zeste 1 polycomb repressive complex 2 subunitENSG0000010879921
NSD2 / O96028 / nuclear receptor binding SET domain protein 2ENSG0000010968521
Q53H47 / SETMAR / SET domain and mariner transposase fusion geneENSG0000017036421
EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunitENSG0000010646220
Q9Y6X0 / SETBP1 / SET binding protein 1ENSG0000015221717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR001214  SET domain
 IPR003616  Post-SET domain
 IPR007728  Pre-SET domain
 IPR011381  Histone H3-K9 methyltransferase
 IPR016197  Chromo-like domain superfamily
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006333 chromatin assembly or disassembly IMP
 biological_processGO:0006338 chromatin remodeling IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0036123 histone H3-K9 dimethylation ISS
 biological_processGO:0036124 histone H3-K9 trimethylation ISS
 biological_processGO:0042754 negative regulation of circadian rhythm ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0071456 cellular response to hypoxia IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046974 histone methyltransferase activity (H3-K9 specific) IDA
 molecular_functionGO:1904047 S-adenosyl-L-methionine binding IDA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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