ENSMUSG00000026646


Mus musculus

Features
Gene ID: ENSMUSG00000026646
  
Biological name :Suv39h2
  
Synonyms : suppressor of variegation 3-9 2 / Suv39h2
  
Possible biological names infered from orthology : Q9H5I1 / suppressor of variegation 3-9 homolog 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A1
Gene start: 3455815
Gene end: 3475031
  
Corresponding Affymetrix probe sets: 10479765 (MoGene1.0st)   1422979_at (Mouse Genome 430 2.0 Array)   1433996_at (Mouse Genome 430 2.0 Array)   1436561_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054169
Ensembl peptide - ENSMUSP00000125485
Ensembl peptide - ENSMUSP00000098026
Ensembl peptide - ENSMUSP00000027956
NCBI entrez gene - 64707     See in Manteia.
MGI - MGI:1890396
RefSeq - NM_022724
RefSeq Peptide - NP_073561
swissprot - A0A0R4J074
swissprot - F6WB49
swissprot - E0CZC9
swissprot - Q8K085
Ensembl - ENSMUSG00000026646
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5F3W5ENSGALG00000013920Gallus gallus
 Q9H5I1ENSG00000152455Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O54864 / Suv39h1 / suppressor of variegation 3-9 1 / O43463* / suppressor of variegation 3-9 homolog 1*ENSMUSG0000003923149
Setd2 / E9Q5F9 / Histone-lysine N-methyltransferase SETD2 / Q9BYW2* / SET domain containing 2*ENSMUSG0000004479125
Ash1l / Q99MY8 / Histone-lysine N-methyltransferase ASH1L / Q9NR48* / ASH1 like histone lysine methyltransferase*ENSMUSG0000002805323
Ehmt2 / Q9Z148 / Histone-lysine N-methyltransferase EHMT2 / Q96KQ7* / euchromatic histone lysine methyltransferase 2*ENSMUSG0000001378723
Setdb1 / SET domain, bifurcated 1 / Q15047*ENSMUSG0000001569723
Ehmt1 / Q5DW34 / Histone-lysine N-methyltransferase EHMT1 / Q9H9B1* / euchromatic histone lysine methyltransferase 1*ENSMUSG0000003689323
Nsd1 / nuclear receptor-binding SET-domain protein 1 / Q96L73*ENSMUSG0000002148821
Ezh1 / P70351 / Histone-lysine N-methyltransferase EZH1 / Q92800* / enhancer of zeste 1 polycomb repressive complex 2 subunit*ENSMUSG0000000692019
Nsd3 / Q6P2L6 / Histone-lysine N-methyltransferase NSD3 / Q9BZ95* / nuclear receptor binding SET domain protein 3*ENSMUSG0000005482319
Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*ENSMUSG0000005740618
Q80UJ9 / Setmar / Histone-lysine N-methyltransferase SETMAR / Q53H47* / SET domain and mariner transposase fusion gene*ENSMUSG0000003463918
Ezh2 / Q61188 / Histone-lysine N-methyltransferase EZH2 / Q15910* / enhancer of zeste 2 polycomb repressive complex 2 subunit*ENSMUSG0000002968718
Q8C267 / Setdb2 / SET domain, bifurcated 2 / Q96T68*ENSMUSG0000007135016
Q9Z180 / Setbp1 / SET-binding protein / Q9Y6X0* / SET binding protein 1*ENSMUSG0000002454815


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR001214  SET domain
 IPR003616  Post-SET domain
 IPR007728  Pre-SET domain
 IPR011381  Histone H3-K9 methyltransferase
 IPR016197  Chromo-like domain superfamily
 IPR023779  Chromo domain, conserved site
 IPR023780  Chromo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006333 chromatin assembly or disassembly IEA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0051567 histone H3-K9 methylation IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046974 histone methyltransferase activity (H3-K9 specific) IEA
 molecular_functionGO:1904047 S-adenosyl-L-methionine binding IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001116 small gonad "reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hfetm3Sly/Hfetm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Suv39h2tm1Jnw/Suv39h2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw,Suv39h2tm1Jnw/Suv39h2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Suv39h1tm1Jnw/Suv39h1+,Suv39h2tm1Jnw/Suv39h2tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Suv39h1tm1Jnw/Suv39h1tm1Jnw
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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