ENSGALG00000024051


Gallus gallus

Features
Gene ID: ENSGALG00000024051
  
Biological name :SETDB1
  
Synonyms : SETDB1 / SET domain bifurcated 1
  
Possible biological names infered from orthology : Q15047
  
Species: Gallus gallus
  
Chr. number: 25
Strand: 1
Band:
Gene start: 2612501
Gene end: 2631106
  
Corresponding Affymetrix probe sets: GgaAffx.510.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000039776
NCBI entrez gene - 100859816     See in Manteia.
RefSeq - XM_015280048
RefSeq - XM_015280049
RefSeq - XM_015280050
RefSeq - XM_015280051
RefSeq - XM_015280047
swissprot - H9L3I9
Ensembl - ENSGALG00000024051
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 setdb1bENSDARG00000099021Danio rerio
 Q15047ENSG00000143379Homo sapiens
 Setdb1ENSMUSG00000015697Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SETDB2 / SET domain bifurcated 2 / Q8C267* / Q96T68*ENSGALG0000001700614
EHMT1 / histone-lysine N-methyltransferase EHMT1 / Q5DW34* / Q9H9B1* / euchromatic histone lysine methyltransferase 1*ENSGALG0000003367811
NSD2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *ENSGALG0000001570510
SETD2 / SET domain containing 2 / E9Q5F9* / Q9BYW2* / Histone-lysine N-methyltransferase SETD2 *ENSGALG000000420519
NSD1 / nuclear receptor binding SET domain protein 1 / Q96L73*ENSGALG000000029719
NSD3 / nuclear receptor binding SET domain protein 3 / Q6P2L6* / Q9BZ95* / Histone-lysine N-methyltransferase NSD3 *ENSGALG000000032999
EZH1 / enhancer of zeste 1 polycomb repressive complex 2 subunit / P70351* / Q92800* / Histone-lysine N-methyltransferase EZH1 *ENSGALG000000030688
ASH1L / ASH1 like histone lysine methyltransferase / Q99MY8* / Q9NR48* / Histone-lysine N-methyltransferase ASH1L *ENSGALG000000146388
EZH2 / enhancer of zeste 2 polycomb repressive complex 2 subunit / Q15910* / Q61188* / Histone-lysine N-methyltransferase EZH2 *ENSGALG000000433997
Q5F3W5 / SUV39H2 / Histone-lysine N-methyltransferase SUV39H2 / Q9H5I1* / suppressor of variegation 3-9 2* / suppressor of variegation 3-9 homolog 2*ENSGALG000000139207
SETBP1 / SET binding protein 1 / Q9Y6X0* / Q9Z180* / SET-binding protein *ENSGALG000000367757


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR001739  Methyl-CpG DNA binding
 IPR002999  Tudor domain
 IPR003616  Post-SET domain
 IPR007728  Pre-SET domain
 IPR016177  DNA-binding domain superfamily
 IPR025796  Histone-lysine N-methyltransferase SETDB1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0090309 positive regulation of methylation-dependent chromatin silencing IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011814 ATF7IP / activating transcription factor 7-interacting protein 1 / Q6VMQ6* / Q7TT18* / activating transcription factor 7 interacting protein*  / reaction / complex






 

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