ENSG00000132275


Homo sapiens

Features
Gene ID: ENSG00000132275
  
Biological name :RRP8
  
Synonyms : O43159 / ribosomal RNA processing 8 / RRP8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.4
Gene start: 6595075
Gene end: 6603620
  
Corresponding Affymetrix probe sets: 1558963_at (Human Genome U133 Plus 2.0 Array)   203170_at (Human Genome U133 Plus 2.0 Array)   203171_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000254605
Ensembl peptide - ENSP00000436960
Ensembl peptide - ENSP00000436246
Ensembl peptide - ENSP00000435873
NCBI entrez gene - 23378     See in Manteia.
OMIM - 615818
RefSeq - XM_017017423
RefSeq - NM_015324
RefSeq - XM_011519955
RefSeq Peptide - NP_056139
swissprot - E9PS87
swissprot - O43159
swissprot - E9PPP6
swissprot - E9PPY3
Ensembl - ENSG00000132275
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rrp8ENSDARG00000071652Danio rerio
 Rrp8ENSMUSG00000030888Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007823  Ribosomal RNA processing protein 8
 IPR023576  UbiE/COQ5 methyltransferase, conserved site
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0042149 cellular response to glucose starvation IMP
 biological_processGO:0046015 regulation of transcription by glucose IMP
 biological_processGO:0071158 positive regulation of cell cycle arrest IMP
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005677 chromatin silencing complex IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0033553 rDNA heterochromatin IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008757 S-adenosylmethionine-dependent methyltransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035064 methylated histone binding IDA


Pathways (from Reactome)
Pathway description
SIRT1 negatively regulates rRNA expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000096717 SIRT1 / Q96EB6 / sirtuin 1  / complex / reaction
 ENSG00000101945 O43463 / SUV39H1 / suppressor of variegation 3-9 homolog 1  / complex / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex / reaction






 

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