ENSMUSG00000030888


Mus musculus

Features
Gene ID: ENSMUSG00000030888
  
Biological name :Rrp8
  
Synonyms : Q9DB85 / Ribosomal RNA-processing protein 8 / Rrp8
  
Possible biological names infered from orthology : O43159 / ribosomal RNA processing 8
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 105731730
Gene end: 105737385
  
Corresponding Affymetrix probe sets: 10566516 (MoGene1.0st)   1416559_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095752
Ensembl peptide - ENSMUSP00000147906
Ensembl peptide - ENSMUSP00000033179
NCBI entrez gene - 101867     See in Manteia.
MGI - MGI:1914251
RefSeq - NM_133951
RefSeq - NM_025897
RefSeq Peptide - NP_080173
RefSeq Peptide - NP_598712
swissprot - Q9DB85
swissprot - E9PVA2
swissprot - A0A1B0GSE7
Ensembl - ENSMUSG00000030888
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rrp8ENSDARG00000071652Danio rerio
 RRP8ENSG00000132275Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007823  Ribosomal RNA processing protein 8
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0046015 regulation of transcription by glucose IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005677 chromatin silencing complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0033553 rDNA heterochromatin IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008757 S-adenosylmethionine-dependent methyltransferase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035064 methylated histone binding IEA


Pathways (from Reactome)
Pathway description
SIRT1 negatively regulates rRNA expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rptortm2b(EUCOMM)Wtsi/Rptortm2b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rptortm2b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020063 Sirt1 / Q923E4 / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q96EB6* / sirtuin 1*  / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / reaction / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction / complex
 ENSMUSG00000039231 O54864 / Suv39h1 / suppressor of variegation 3-9 1 / O43463* / suppressor of variegation 3-9 homolog 1*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr