ENSG00000132002


Homo sapiens

Features
Gene ID: ENSG00000132002
  
Biological name :DNAJB1
  
Synonyms : DNAJB1 / DnaJ heat shock protein family (Hsp40) member B1 / P25685
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.12
Gene start: 14514770
Gene end: 14529770
  
Corresponding Affymetrix probe sets: 200664_s_at (Human Genome U133 Plus 2.0 Array)   200666_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471798
Ensembl peptide - ENSP00000471603
Ensembl peptide - ENSP00000472886
Ensembl peptide - ENSP00000254322
Ensembl peptide - ENSP00000444212
Ensembl peptide - ENSP00000469221
Ensembl peptide - ENSP00000470063
Ensembl peptide - ENSP00000470460
Ensembl peptide - ENSP00000470596
Ensembl peptide - ENSP00000471073
NCBI entrez gene - 3337     See in Manteia.
OMIM - 604572
RefSeq - XM_011527956
RefSeq - NM_001300914
RefSeq - NM_001313964
RefSeq - NM_006145
RefSeq - XM_006722733
RefSeq - XM_006722734
RefSeq Peptide - NP_006136
RefSeq Peptide - NP_001287843
RefSeq Peptide - NP_001300893
swissprot - A0A1B0GX60
swissprot - M0QXK0
swissprot - M0QYT3
swissprot - M0QZD0
swissprot - M0R080
swissprot - M0R1D6
swissprot - M0R128
swissprot - P25685
swissprot - Q6FHS4
Ensembl - ENSG00000132002
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnajb1aENSDARG00000099383Danio rerio
 dnajb1bENSDARG00000041394Danio rerio
 Dnajb1ENSMUSG00000005483Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DNAJB4 / Q9UDY4 / DnaJ heat shock protein family (Hsp40) member B4ENSG0000016261666
DNAJB5 / O75953 / DnaJ heat shock protein family (Hsp40) member B5ENSG0000013709462
P59910 / DNAJB13 / DnaJ heat shock protein family (Hsp40) member B13ENSG0000018772647
DNAJB6 / O75190 / DnaJ heat shock protein family (Hsp40) member B6ENSG0000010599326
DNAJB2 / P25686 / DnaJ heat shock protein family (Hsp40) member B2ENSG0000013592423
DNAJB7 / Q7Z6W7 / DnaJ heat shock protein family (Hsp40) member B7ENSG0000017240423
DNAJB8 / Q8NHS0 / DnaJ heat shock protein family (Hsp40) member B8ENSG0000017940721
DNAJB9 / Q9UBS3 / DnaJ heat shock protein family (Hsp40) member B9ENSG0000012859017


Protein motifs (from Interpro)
Interpro ID Name
 IPR001623  DnaJ domain
 IPR002939  Chaperone DnaJ, C-terminal
 IPR008971  HSP40/DnaJ peptide-binding
 IPR018253  DnaJ domain, conserved site
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006986 response to unfolded protein TAS
 biological_processGO:0032781 positive regulation of ATPase activity IDA
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding IDA
 biological_processGO:0090084 negative regulation of inclusion body assembly IDA
 biological_processGO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress IDA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001671 ATPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030544 Hsp70 protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0051087 chaperone binding IPI
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000096717 SIRT1 / Q96EB6 / sirtuin 1  / complex / reaction
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / complex
 ENSG00000204389 HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A  / reaction / complex
 ENSG00000089022 Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5  / reaction / complex
 ENSG00000132002 DNAJB1 / P25685 / DnaJ heat shock protein family (Hsp40) member B1  / complex
 ENSG00000204388 HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B  / reaction / complex
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / reaction / complex
 ENSG00000149196 Q53FT3 / HIKESHI / Hikeshi, heat shock protein nuclear import factor  / reaction
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction






 

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