ENSG00000158941


Homo sapiens

Features
Gene ID: ENSG00000158941
  
Biological name :CCAR2
  
Synonyms : CCAR2 / cell cycle and apoptosis regulator 2 / Q8N163
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.3
Gene start: 22604632
Gene end: 22621514
  
Corresponding Affymetrix probe sets: 221070_s_at (Human Genome U133 Plus 2.0 Array)   225187_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429739
Ensembl peptide - ENSP00000484850
Ensembl peptide - ENSP00000431046
Ensembl peptide - ENSP00000430978
Ensembl peptide - ENSP00000430974
Ensembl peptide - ENSP00000429773
Ensembl peptide - ENSP00000429769
Ensembl peptide - ENSP00000310670
Ensembl peptide - ENSP00000373930
Ensembl peptide - ENSP00000428549
Ensembl peptide - ENSP00000428843
NCBI entrez gene - 57805     See in Manteia.
OMIM - 607359
RefSeq - NM_021174
RefSeq - XM_011544603
RefSeq - XM_011544604
RefSeq - XM_017013717
RefSeq Peptide - NP_066997
swissprot - H0YB24
swissprot - E5RHJ4
swissprot - H0YC69
swissprot - Q8N163
swissprot - H0YC58
swissprot - E5RHH8
swissprot - E5RGU7
swissprot - E5RFJ3
swissprot - A0A087X2B6
swissprot - G3V119
Ensembl - ENSG00000158941
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccar2ENSDARG00000038302Danio rerio
 Ccar2ENSMUSG00000033712Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCAR1 / Q8IX12 / cell division cycle and apoptosis regulator 1ENSG0000006033935


Protein motifs (from Interpro)
Interpro ID Name
 IPR011992  EF-hand domain pair
 IPR025223  S1-like RNA binding domain
 IPR025224  Cell cycle and apoptosis regulator protein
 IPR025954  DBC1/CARP1 catalytically inactive NUDIX hydrolase domain
 IPR028811  Cell cycle and apoptosis regulator protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0009411 response to UV IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0031647 regulation of protein stability IDA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0032784 regulation of DNA-templated transcription, elongation IMP
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043086 negative regulation of catalytic activity IMP
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0090311 regulation of protein deacetylation IDA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:2000003 positive regulation of DNA damage checkpoint IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005681 spliceosomal complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0044609 DBIRD complex IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004857 enzyme inhibitor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000096717 SIRT1 / Q96EB6 / sirtuin 1  / complex / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction
 ENSG00000175054 ATR / Q13535 / ATR serine/threonine kinase  / reaction






 

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