ENSMUSG00000033712


Mus musculus

Features
Gene ID: ENSMUSG00000033712
  
Biological name :Ccar2
  
Synonyms : Ccar2 / Cell cycle and apoptosis regulator protein 2 / Q8VDP4
  
Possible biological names infered from orthology : cell cycle and apoptosis regulator 2 / Q8N163
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D2
Gene start: 70138164
Gene end: 70153811
  
Corresponding Affymetrix probe sets: 10421227 (MoGene1.0st)   1426012_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036924
NCBI entrez gene - 219158     See in Manteia.
MGI - MGI:2444228
RefSeq - XM_006518897
RefSeq - NM_146055
RefSeq - XM_006518896
RefSeq Peptide - NP_666167
swissprot - Q8VDP4
Ensembl - ENSMUSG00000033712
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccar2ENSDARG00000038302Danio rerio
 CCAR2ENSG00000158941Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccar1 / Q8CH18 / Cell division cycle and apoptosis regulator protein 1 / Q8IX12* / cell division cycle and apoptosis regulator 1*ENSMUSG0000002007434


Protein motifs (from Interpro)
Interpro ID Name
 IPR011992  EF-hand domain pair
 IPR025223  S1-like RNA binding domain
 IPR025224  Cell cycle and apoptosis regulator protein
 IPR025954  DBC1/CARP1 catalytically inactive NUDIX hydrolase domain
 IPR028811  Cell cycle and apoptosis regulator protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008380 RNA splicing ISO
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032784 regulation of DNA-templated transcription, elongation IEA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090311 regulation of protein deacetylation IEA
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:2000003 positive regulation of DNA damage checkpoint IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0044609 DBIRD complex ISO
 molecular_functionGO:0000993 RNA polymerase II core binding IEA
 molecular_functionGO:0004857 enzyme inhibitor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IEA


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
Genetic Background: involves: C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
Genetic Background: involves: C57BL/6J

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
Genetic Background: involves: C57BL/6J

 MP:0005283 increased unsaturated fatty acid level "greater than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain has one or more double or triple carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
Genetic Background: involves: C57BL/6J

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
Genetic Background: involves: C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
Genetic Background: involves: C57BL/6J

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
Genetic Background: involves: C57BL/6J

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
Genetic Background: involves: C57BL/6J

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
Genetic Background: involves: C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
Genetic Background: involves: C57BL/6J

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

 MP:0020102 increased hepatic glucose production "increased production of glucose in the liver" [GOC:NV]
Show

Allelic Composition: Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020063 Sirt1 / Q923E4 / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q96EB6* / sirtuin 1*  / reaction / complex
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr