93759


Mus musculus (NCBI)

Features
Gene ID: 93759
  
Biological name :
  
Synonyms : AA673258|SIR2L1|Sir2|Sir2a|Sir2alpha / Sirt1 / sirtuin 1
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1418640_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 227430309
RefSeq - 9790229
RefSeq - NC_000076.6
RefSeq - NP_001153061.1
RefSeq - NP_062786.1
RefSeq - NM_019812.3
RefSeq - NM_001159589.2
RefSeq - NM_001159590.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000020063 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000012 single strand break repair ISO
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0000183 chromatin silencing at rDNA ISO
 biological_processGO:0000720 pyrimidine dimer repair by nucleotide-excision repair ISO
 biological_processGO:0000731 DNA synthesis involved in DNA repair IMP
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0001542 ovulation from ovarian follicle IMP
 biological_processGO:0001678 cellular glucose homeostasis IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0002821 positive regulation of adaptive immune response ISO
 biological_processGO:0006325 chromatin organization ISO
 biological_processGO:0006343 establishment of chromatin silencing ISO
 biological_processGO:0006344 maintenance of chromatin silencing ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006476 protein deacetylation ISO
 biological_processGO:0006642 triglyceride mobilization IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006979 response to oxidative stress ISO
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007346 regulation of mitotic cell cycle ISO
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA
 biological_processGO:0009267 cellular response to starvation IMP
 biological_processGO:0010460 positive regulation of heart rate ISO
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process ISO
 biological_processGO:0010875 positive regulation of cholesterol efflux IMP
 biological_processGO:0010883 regulation of lipid storage IMP
 biological_processGO:0010906 regulation of glucose metabolic process IMP
 biological_processGO:0010934 macrophage cytokine production IMP
 biological_processGO:0010976 positive regulation of neuron projection development ISO
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0014858 positive regulation of skeletal muscle cell proliferation ISO
 biological_processGO:0016239 positive regulation of macroautophagy ISO
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0016575 histone deacetylation ISO
 biological_processGO:0018394 peptidyl-lysine acetylation ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030225 macrophage differentiation IMP
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0031393 negative regulation of prostaglandin biosynthetic process IMP
 biological_processGO:0031648 protein destabilization ISO
 biological_processGO:0031937 positive regulation of chromatin silencing ISO
 biological_processGO:0032007 negative regulation of TOR signaling ISO
 biological_processGO:0032071 regulation of endodeoxyribonuclease activity ISO
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0032720 negative regulation of tumor necrosis factor production ISO
 biological_processGO:0032868 response to insulin IDA
 biological_processGO:0032922 circadian regulation of gene expression ISO
 biological_processGO:0033158 regulation of protein import into nucleus, translocation ISO
 biological_processGO:0033210 leptin-mediated signaling pathway IMP
 biological_processGO:0034391 regulation of smooth muscle cell apoptotic process IDA
 biological_processGO:0034983 peptidyl-lysine deacetylation ISO
 biological_processGO:0035356 cellular triglyceride homeostasis IMP
 biological_processGO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway IMP
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
 biological_processGO:0042127 regulation of cell proliferation ISO
 biological_processGO:0042326 negative regulation of phosphorylation ISO
 biological_processGO:0042542 response to hydrogen peroxide ISO
 biological_processGO:0042595 behavioral response to starvation IMP
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
 biological_processGO:0042981 regulation of apoptotic process ISO
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0043392 negative regulation of DNA binding ISO
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISO
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration ISO
 biological_processGO:0044321 response to leptin IMP
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process ISO
 biological_processGO:0045471 response to ethanol ISO
 biological_processGO:0045599 negative regulation of fat cell differentiation IMP
 biological_processGO:0045722 positive regulation of gluconeogenesis ISO
 biological_processGO:0045739 positive regulation of DNA repair ISO
 biological_processGO:0045766 positive regulation of angiogenesis ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway ISO
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050872 white fat cell differentiation IMP
 biological_processGO:0051097 negative regulation of helicase activity ISO
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation IMP
 biological_processGO:0051574 positive regulation of histone H3-K9 methylation ISO
 biological_processGO:0051898 negative regulation of protein kinase B signaling ISO
 biological_processGO:0055089 fatty acid homeostasis IMP
 biological_processGO:0060125 negative regulation of growth hormone secretion ISO
 biological_processGO:0060548 negative regulation of cell death ISO
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway ISO
 biological_processGO:0061051 positive regulation of cell growth involved in cardiac muscle cell development ISO
 biological_processGO:0070301 cellular response to hydrogen peroxide ISO
 biological_processGO:0070857 regulation of bile acid biosynthetic process IMP
 biological_processGO:0070914 UV-damage excision repair ISO
 biological_processGO:0070932 histone H3 deacetylation ISO
 biological_processGO:0071356 cellular response to tumor necrosis factor ISO
 biological_processGO:0071441 negative regulation of histone H3-K14 acetylation ISO
 biological_processGO:0071456 cellular response to hypoxia ISO
 biological_processGO:0071479 cellular response to ionizing radiation IMP
 biological_processGO:0071900 regulation of protein serine/threonine kinase activity ISO
 biological_processGO:0090312 positive regulation of protein deacetylation ISO
 biological_processGO:0090335 regulation of brown fat cell differentiation IMP
 biological_processGO:0090400 stress-induced premature senescence ISO
 biological_processGO:0097009 energy homeostasis ISO
 biological_processGO:0097755 positive regulation of blood vessel diameter ISO
 biological_processGO:1900113 negative regulation of histone H3-K9 trimethylation IDA
 biological_processGO:1900181 negative regulation of protein localization to nucleus ISO
 biological_processGO:1901215 negative regulation of neuron death IGI
 biological_processGO:1901984 negative regulation of protein acetylation ISO
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903427 negative regulation of reactive oxygen species biosynthetic process ISO
 biological_processGO:1904179 positive regulation of adipose tissue development IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000111 positive regulation of macrophage apoptotic process IMP
 biological_processGO:2000270 negative regulation of fibroblast apoptotic process ISO
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity ISO
 biological_processGO:2000481 positive regulation of cAMP-dependent protein kinase activity ISO
 biological_processGO:2000614 positive regulation of thyroid-stimulating hormone secretion ISO
 biological_processGO:2000619 negative regulation of histone H4-K16 acetylation ISO
 biological_processGO:2000655 negative regulation of cellular response to testosterone stimulus ISO
 biological_processGO:2000757 negative regulation of peptidyl-lysine acetylation ISO
 biological_processGO:2000773 negative regulation of cellular senescence ISO
 biological_processGO:2000774 positive regulation of cellular senescence ISO
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope ISO
 cellular_componentGO:0005637 nuclear inner membrane ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005677 chromatin silencing complex ISO
 cellular_componentGO:0005719 nuclear euchromatin ISO
 cellular_componentGO:0005720 nuclear heterochromatin ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016605 PML body ISO
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0030426 growth cone ISO
 cellular_componentGO:0033553 rDNA heterochromatin ISO
 cellular_componentGO:0035098 ESC/E(Z) complex ISO
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0002039 p53 binding ISO
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0004407 histone deacetylase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity ISO
 molecular_functionGO:0019213 deacetylase activity ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0033558 protein deacetylase activity ISO
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity ISO
 molecular_functionGO:0035257 nuclear hormone receptor binding ISO
 molecular_functionGO:0042393 histone binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043398 HLH domain binding ISO
 molecular_functionGO:0043422 protein kinase B binding ISO
 molecular_functionGO:0043425 bHLH transcription factor binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding ISO
 molecular_functionGO:0070403 NAD+ binding IEA
 molecular_functionGO:1990254 keratin filament binding ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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