ENSG00000120694


Homo sapiens

Features
Gene ID: ENSG00000120694
  
Biological name :HSPH1
  
Synonyms : heat shock protein family H (Hsp110) member 1 / HSPH1 / Q92598
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q12.3
Gene start: 31134974
Gene end: 31162388
  
Corresponding Affymetrix probe sets: 206976_s_at (Human Genome U133 Plus 2.0 Array)   208744_x_at (Human Genome U133 Plus 2.0 Array)   235573_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000396090
Ensembl peptide - ENSP00000369768
Ensembl peptide - ENSP00000408991
Ensembl peptide - ENSP00000487365
Ensembl peptide - ENSP00000473512
Ensembl peptide - ENSP00000318687
NCBI entrez gene - 10808     See in Manteia.
OMIM - 610703
RefSeq - XM_017020364
RefSeq - NM_001286503
RefSeq - NM_001286504
RefSeq - NM_001286505
RefSeq - NM_006644
RefSeq - XM_005266236
RefSeq - XM_011534887
RefSeq - XM_011534888
RefSeq - XM_017020361
RefSeq - XM_017020362
RefSeq - XM_017020363
RefSeq Peptide - NP_001273432
RefSeq Peptide - NP_001273433
RefSeq Peptide - NP_001273434
RefSeq Peptide - NP_006635
swissprot - R4GN69
swissprot - A0A0A0MSM0
swissprot - A0A024RDQ0
swissprot - A0A024RDS1
swissprot - Q5TBM3
swissprot - Q92598
Ensembl - ENSG00000120694
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsph1ENSDARG00000019874Danio rerio
 HSPH1ENSGALG00000017077Gallus gallus
 Hsph1ENSMUSG00000029657Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HSPA4 / P34932 / heat shock protein family A (Hsp70) member 4ENSG0000017060660
HSPA4L / O95757 / heat shock protein family A (Hsp70) member 4 likeENSG0000016407055
HYOU1 / Q9Y4L1 / hypoxia up-regulated 1ENSG0000014942826


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006986 response to unfolded protein TAS
 biological_processGO:0045345 positive regulation of MHC class I biosynthetic process TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding IEA
 biological_processGO:0051135 positive regulation of NK T cell activation TAS
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1903748 negative regulation of establishment of protein localization to mitochondrion IEA
 biological_processGO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide IEA
 biological_processGO:1903753 negative regulation of p38MAPK cascade IEA
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071682 endocytic vesicle lumen TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000774 adenyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0043014 alpha-tubulin binding IEA


Pathways (from Reactome)
Pathway description
Scavenging by Class F Receptors
Regulation of HSF1-mediated heat shock response


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000204388 HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B  / reaction
 ENSG00000204389 HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A  / reaction






 

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