ENSG00000082175


Homo sapiens

Features
Gene ID: ENSG00000082175
  
Biological name :PGR
  
Synonyms : P06401 / PGR / progesterone receptor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q22.1
Gene start: 101029624
Gene end: 101130524
  
Corresponding Affymetrix probe sets: 208305_at (Human Genome U133 Plus 2.0 Array)   228554_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481227
Ensembl peptide - ENSP00000436803
Ensembl peptide - ENSP00000482698
Ensembl peptide - ENSP00000487607
Ensembl peptide - ENSP00000263463
Ensembl peptide - ENSP00000325120
Ensembl peptide - ENSP00000432352
Ensembl peptide - ENSP00000432914
Ensembl peptide - ENSP00000436561
NCBI entrez gene - 5241     See in Manteia.
OMIM - 607311
RefSeq - XM_006718858
RefSeq - NM_000926
RefSeq - NM_001202474
RefSeq - NM_001271161
RefSeq - NM_001271162
RefSeq Peptide - NP_001189403
RefSeq Peptide - NP_001258090
RefSeq Peptide - NP_001258091
RefSeq Peptide - NP_000917
swissprot - Q8NG44
swissprot - A0A087WXR4
swissprot - Q8NG45
swissprot - P06401
swissprot - A0A0J9YVP1
swissprot - Q8NG42
Ensembl - ENSG00000082175
  
Related genetic diseases (OMIM): 264080 - ?Progesterone resistance, 264080

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pgrENSDARG00000035966Danio rerio
 PGRENSGALG00000017195Gallus gallus
 PgrENSMUSG00000031870Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR3C2 / P08235 / nuclear receptor subfamily 3 group C member 2ENSG0000015162332
AR / P10275 / androgen receptorENSG0000016908329
NR3C1 / P04150 / nuclear receptor subfamily 3 group C member 1ENSG0000011358029
ESR1 / P03372 / estrogen receptor 1ENSG0000009183114
NR4A1 / P22736 / nuclear receptor subfamily 4 group A member 1ENSG0000012335814
ESR2 / Q92731 / estrogen receptor 2ENSG0000014000913
ESRRA / P11474 / estrogen related receptor alphaENSG0000017315312
ESRRG / P62508 / estrogen related receptor gammaENSG0000019648212
ESRRB / O95718 / estrogen related receptor betaENSG0000011971511
NR4A2 / P43354 / nuclear receptor subfamily 4 group A member 2ENSG0000015323411
NR4A3 / Q92570 / nuclear receptor subfamily 4 group A member 3ENSG0000011950811


Protein motifs (from Interpro)
Interpro ID Name
 IPR000128  Progesterone receptor
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001542 ovulation from ovarian follicle IEA
 biological_processGO:0002070 epithelial cell maturation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0010629 negative regulation of gene expression IEP
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0038001 paracrine signaling IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0050678 regulation of epithelial cell proliferation IEA
 biological_processGO:0050847 progesterone receptor signaling pathway IEA
 biological_processGO:0060748 tertiary branching involved in mammary gland duct morphogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051117 ATPase binding IDA


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0001939 Metabolism abnormality 
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 HP:0008222 Female infertility 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004478 FKBP4 / Q02790 / FK506 binding protein 4  / complex
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex
 ENSG00000110958 PTGES3 / Q15185 / prostaglandin E synthase 3  / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / complex






 

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