ENSG00000140009


Homo sapiens

Features
Gene ID: ENSG00000140009
  
Biological name :ESR2
  
Synonyms : ESR2 / estrogen receptor 2 / Q92731
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q23.3
Gene start: 64084232
Gene end: 64338112
  
Corresponding Affymetrix probe sets: 210780_at (Human Genome U133 Plus 2.0 Array)   211117_x_at (Human Genome U133 Plus 2.0 Array)   211118_x_at (Human Genome U133 Plus 2.0 Array)   211119_at (Human Genome U133 Plus 2.0 Array)   211120_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452485
Ensembl peptide - ENSP00000451582
Ensembl peptide - ENSP00000452426
Ensembl peptide - ENSP00000267525
Ensembl peptide - ENSP00000335551
Ensembl peptide - ENSP00000343925
Ensembl peptide - ENSP00000345616
Ensembl peptide - ENSP00000351412
Ensembl peptide - ENSP00000450488
Ensembl peptide - ENSP00000450699
NCBI entrez gene - 2100     See in Manteia.
OMIM - 601663
RefSeq - XM_017021084
RefSeq - NM_001214902
RefSeq - NM_001271876
RefSeq - NM_001271877
RefSeq - NM_001291712
RefSeq - NM_001291723
RefSeq - NM_001437
RefSeq - XM_017021079
RefSeq - XM_017021080
RefSeq - XM_017021081
RefSeq - XM_017021082
RefSeq - XM_017021083
RefSeq - NM_001040275
RefSeq Peptide - NP_001278652
RefSeq Peptide - NP_001035365
RefSeq Peptide - NP_001201831
RefSeq Peptide - NP_001258805
RefSeq Peptide - NP_001428
RefSeq Peptide - NP_001258806
RefSeq Peptide - NP_001278641
swissprot - Q7LCB3
swissprot - G3V5S2
swissprot - Q92731
swissprot - F1D8N3
Ensembl - ENSG00000140009
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 esr2aENSDARG00000016454Danio rerio
 esr2bENSDARG00000034181Danio rerio
 ESR2ENSGALG00000011801Gallus gallus
 Esr2ENSMUSG00000021055Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ESR1 / P03372 / estrogen receptor 1ENSG0000009183148
ESRRB / O95718 / estrogen related receptor betaENSG0000011971528
ESRRA / P11474 / estrogen related receptor alphaENSG0000017315328
ESRRG / P62508 / estrogen related receptor gammaENSG0000019648227
NR3C2 / P08235 / nuclear receptor subfamily 3 group C member 2ENSG0000015162324
NR4A1 / P22736 / nuclear receptor subfamily 4 group A member 1ENSG0000012335824
NR3C1 / P04150 / nuclear receptor subfamily 3 group C member 1ENSG0000011358023
PGR / P06401 / progesterone receptorENSG0000008217522
AR / P10275 / androgen receptorENSG0000016908321
NR4A3 / Q92570 / nuclear receptor subfamily 4 group A member 3ENSG0000011950820
NR4A2 / P43354 / nuclear receptor subfamily 4 group A member 2ENSG0000015323420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR021064  Estrogen receptor beta, N-terminal
 IPR024178  Oestrogen receptor/oestrogen-related receptor
 IPR028355  Estrogen receptor beta/gamma
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0030308 negative regulation of cell growth NAS
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway TAS
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:1900116 extracellular negative regulation of signal transduction IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003707 steroid hormone receptor activity TAS
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0004879 nuclear receptor activity NAS
 molecular_functionGO:0005496 steroid binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030284 estrogen receptor activity TAS
 molecular_functionGO:0034056 estrogen response element binding IDA
 molecular_functionGO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048019 receptor antagonist activity NAS


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Nuclear Receptor transcription pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ESR-mediated signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / reaction / complex
 ENSG00000110958 PTGES3 / Q15185 / prostaglandin E synthase 3  / complex
 ENSG00000140009 ESR2 / Q92731 / estrogen receptor 2  / complex / reaction
 ENSG00000171497 PPID / Q08752 / peptidylprolyl isomerase D  / complex
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / complex






 

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