ENSG00000173153


Homo sapiens

Features
Gene ID: ENSG00000173153
  
Biological name :ESRRA
  
Synonyms : ESRRA / estrogen related receptor alpha / P11474
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 64305572
Gene end: 64316743
  
Corresponding Affymetrix probe sets: 1487_at (Human Genome U133 Plus 2.0 Array)   203193_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000444710
Ensembl peptide - ENSP00000439896
Ensembl peptide - ENSP00000441970
Ensembl peptide - ENSP00000000442
Ensembl peptide - ENSP00000384851
Ensembl peptide - ENSP00000385971
NCBI entrez gene - 2101     See in Manteia.
OMIM - 601998
RefSeq - XM_017017313
RefSeq - NM_001282450
RefSeq - NM_001282451
RefSeq - NM_004451
RefSeq Peptide - NP_001269379
RefSeq Peptide - NP_001269380
RefSeq Peptide - NP_004442
swissprot - H0YGT3
swissprot - Q569H8
swissprot - P11474
swissprot - F5GWT5
swissprot - F5H0E9
Ensembl - ENSG00000173153
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 esrraENSDARG00000069266Danio rerio
 EsrraENSMUSG00000024955Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ESRRB / O95718 / estrogen related receptor betaENSG0000011971561
ESRRG / P62508 / estrogen related receptor gammaENSG0000019648259
ESR1 / P03372 / estrogen receptor 1ENSG0000009183135
ESR2 / Q92731 / estrogen receptor 2ENSG0000014000935
NR4A1 / P22736 / nuclear receptor subfamily 4 group A member 1ENSG0000012335829
NR3C2 / P08235 / nuclear receptor subfamily 3 group C member 2ENSG0000015162328
NR4A2 / P43354 / nuclear receptor subfamily 4 group A member 2ENSG0000015323427
NR3C1 / P04150 / nuclear receptor subfamily 3 group C member 1ENSG0000011358027
PGR / P06401 / progesterone receptorENSG0000008217527
NR4A3 / Q92570 / nuclear receptor subfamily 4 group A member 3ENSG0000011950826
AR / P10275 / androgen receptorENSG0000016908323


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR024178  Oestrogen receptor/oestrogen-related receptor
 IPR027289  Oestrogen-related receptor
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007005 mitochondrion organization TAS
 biological_processGO:0030278 regulation of ossification IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045667 regulation of osteoblast differentiation IEA
 biological_processGO:0045670 regulation of osteoclast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:1900078 positive regulation of cellular response to insulin stimulus IEA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0045171 intercellular bridge IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity TAS
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
Regulation of RUNX2 expression and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000155846 Q86YN6 / PPARGC1B / PPARG coactivator 1 beta  / complex
 ENSG00000109819 Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha  / complex






 

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