ENSG00000155846


Homo sapiens

Features
Gene ID: ENSG00000155846
  
Biological name :PPARGC1B
  
Synonyms : PPARGC1B / PPARG coactivator 1 beta / Q86YN6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q32
Gene start: 149730298
Gene end: 149855022
  
Corresponding Affymetrix probe sets: 1553639_a_at (Human Genome U133 Plus 2.0 Array)   1555282_a_at (Human Genome U133 Plus 2.0 Array)   1563943_at (Human Genome U133 Plus 2.0 Array)   232181_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000353638
Ensembl peptide - ENSP00000384403
Ensembl peptide - ENSP00000409364
Ensembl peptide - ENSP00000312649
Ensembl peptide - ENSP00000377855
NCBI entrez gene - 133522     See in Manteia.
OMIM - 608886
RefSeq - XM_011537556
RefSeq - NM_001172698
RefSeq - NM_001172699
RefSeq - NM_133263
RefSeq - XM_005268372
RefSeq - XM_011537553
RefSeq - XM_011537554
RefSeq - XM_011537555
RefSeq Peptide - NP_001166169
RefSeq Peptide - NP_001166170
RefSeq Peptide - NP_573570
swissprot - H0Y713
swissprot - Q86YN6
Ensembl - ENSG00000155846
  
Related genetic diseases (OMIM): 601665 - {Obesity, variation in}, 601665
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppargc1bENSDARG00000101569Danio rerio
 PPARGC1BENSGALG00000043389Gallus gallus
 Q8VHJ7ENSMUSG00000033871Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UBK2 / PPARGC1A / PPARG coactivator 1 alphaENSG0000010981924
PPRC1 / Q5VV67 / peroxisome proliferator-activated receptor gamma, coactivator-related 1ENSG0000014884024


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR034177  PPARGC1B, RNA recognition motif
 IPR034605  PGC-1
 IPR034621  Peroxisome proliferator-activated receptor gamma coactivator 1-beta
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006390 mitochondrial transcription IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0010694 positive regulation of alkaline phosphatase activity IEA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IDA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045780 positive regulation of bone resorption IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IBA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0060346 bone trabecula formation IEA
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016592 mediator complex IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IDA
 molecular_functionGO:0050682 AF-2 domain binding IPI


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Regulation of RUNX2 expression and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000173153 ESRRA / P11474 / estrogen related receptor alpha  / complex
 ENSG00000106459 NRF1 / Q16656 / nuclear respiratory factor 1  / reaction / complex






 

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