ENSG00000119508


Homo sapiens

Features
Gene ID: ENSG00000119508
  
Biological name :NR4A3
  
Synonyms : NR4A3 / nuclear receptor subfamily 4 group A member 3 / Q92570
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q31.1
Gene start: 99821855
Gene end: 99866891
  
Corresponding Affymetrix probe sets: 207978_s_at (Human Genome U133 Plus 2.0 Array)   209959_at (Human Genome U133 Plus 2.0 Array)   216979_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482027
Ensembl peptide - ENSP00000333122
Ensembl peptide - ENSP00000340301
Ensembl peptide - ENSP00000378531
NCBI entrez gene - 8013     See in Manteia.
OMIM - 600542
RefSeq - XM_017015162
RefSeq - NM_006981
RefSeq - NM_173199
RefSeq - NM_173200
RefSeq Peptide - NP_008912
RefSeq Peptide - NP_775291
RefSeq Peptide - NP_775292
swissprot - Q92570
swissprot - A0A024R168
Ensembl - ENSG00000119508
  
Related genetic diseases (OMIM): 612237 - Chondrosarcoma, extraskeletal myxoid, 612237

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr4a3ENSDARG00000055854Danio rerio
 NR4A3ENSGALG00000013568Gallus gallus
 Nr4a3ENSMUSG00000028341Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR4A2 / P43354 / nuclear receptor subfamily 4 group A member 2ENSG0000015323455
NR4A1 / P22736 / nuclear receptor subfamily 4 group A member 1ENSG0000012335847
NR3C2 / P08235 / nuclear receptor subfamily 3 group C member 2ENSG0000015162319
ESRRG / P62508 / estrogen related receptor gammaENSG0000019648217
ESR2 / Q92731 / estrogen receptor 2ENSG0000014000917
ESRRA / P11474 / estrogen related receptor alphaENSG0000017315317
ESR1 / P03372 / estrogen receptor 1ENSG0000009183117
AR / P10275 / androgen receptorENSG0000016908316
NR3C1 / P04150 / nuclear receptor subfamily 3 group C member 1ENSG0000011358016
ESRRB / O95718 / estrogen related receptor betaENSG0000011971516
PGR / P06401 / progesterone receptorENSG0000008217516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003070  Orphan nuclear receptor
 IPR003072  Orphan nuclear receptor, NOR1 type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0009444 pyruvate oxidation IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010828 positive regulation of glucose transmembrane transport IDA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0030534 adult behavior IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032765 positive regulation of mast cell cytokine production IEA
 biological_processGO:0035726 common myeloid progenitor cell proliferation IEA
 biological_processGO:0038097 positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043303 mast cell degranulation IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0044320 cellular response to leptin stimulus IEA
 biological_processGO:0045333 cellular respiration IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046321 positive regulation of fatty acid oxidation IEA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IDA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048752 semicircular canal morphogenesis IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0060005 vestibular reflex IEA
 biological_processGO:0061469 regulation of type B pancreatic cell proliferation IEA
 biological_processGO:0071376 cellular response to corticotropin-releasing hormone stimulus IEA
 biological_processGO:0071870 cellular response to catecholamine stimulus IEA
 biological_processGO:0097009 energy homeostasis IEA
 biological_processGO:1900625 positive regulation of monocyte aggregation IMP
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death IEA
 biological_processGO:1903208 negative regulation of hydrogen peroxide-induced neuron death IEA
 biological_processGO:2000108 positive regulation of leukocyte apoptotic process IEA
 biological_processGO:2000253 positive regulation of feeding behavior IEA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0042629 mast cell granule IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001223 transcription coactivator binding IEA
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity TAS
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0004887 thyroid hormone receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001428 Somatic mutation 
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 HP:0006765 Increased risk of chondrosarcoma 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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