ENSG00000153234


Homo sapiens

Features
Gene ID: ENSG00000153234
  
Biological name :NR4A2
  
Synonyms : NR4A2 / nuclear receptor subfamily 4 group A member 2 / P43354
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q24.1
Gene start: 156324432
Gene end: 156342348
  
Corresponding Affymetrix probe sets: 204621_s_at (Human Genome U133 Plus 2.0 Array)   204622_x_at (Human Genome U133 Plus 2.0 Array)   216248_s_at (Human Genome U133 Plus 2.0 Array)   235739_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388120
Ensembl peptide - ENSP00000415632
Ensembl peptide - ENSP00000410952
Ensembl peptide - ENSP00000406808
Ensembl peptide - ENSP00000394671
Ensembl peptide - ENSP00000389986
Ensembl peptide - ENSP00000344479
Ensembl peptide - ENSP00000385379
Ensembl peptide - ENSP00000386747
Ensembl peptide - ENSP00000386993
NCBI entrez gene - 4929     See in Manteia.
OMIM - 601828
RefSeq - XM_017004220
RefSeq - NM_006186
RefSeq - XM_005246621
RefSeq - XM_005246622
RefSeq - XM_006712553
RefSeq - XM_011511246
RefSeq - XM_017004219
RefSeq Peptide - NP_006177
swissprot - P43354
swissprot - C9J8W4
swissprot - C9IYM5
swissprot - C9JWQ1
swissprot - F1D8N6
swissprot - F8W6I3
swissprot - E9PBQ4
swissprot - H7BZ00
Ensembl - ENSG00000153234
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr4a2aENSDARG00000017007Danio rerio
 NR4A2ENSGALG00000012538Gallus gallus
 Nr4a2ENSMUSG00000026826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR4A3 / Q92570 / nuclear receptor subfamily 4 group A member 3ENSG0000011950859
NR4A1 / P22736 / nuclear receptor subfamily 4 group A member 1ENSG0000012335856
NR3C2 / P08235 / nuclear receptor subfamily 3 group C member 2ENSG0000015162320
ESRRG / P62508 / estrogen related receptor gammaENSG0000019648220
ESR1 / P03372 / estrogen receptor 1ENSG0000009183119
ESRRB / O95718 / estrogen related receptor betaENSG0000011971519
ESRRA / P11474 / estrogen related receptor alphaENSG0000017315319
PGR / P06401 / progesterone receptorENSG0000008217518
NR3C1 / P04150 / nuclear receptor subfamily 3 group C member 1ENSG0000011358018
AR / P10275 / androgen receptorENSG0000016908317
ESR2 / Q92731 / estrogen receptor 2ENSG0000014000917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003070  Orphan nuclear receptor
 IPR003073  Orphan nuclear receptor, NURR type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001764 neuron migration TAS
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010467 gene expression IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IEA
 biological_processGO:0021953 central nervous system neuron differentiation IEA
 biological_processGO:0021986 habenula development IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IDA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0042053 regulation of dopamine metabolic process IEA
 biological_processGO:0042416 dopamine biosynthetic process IEA
 biological_processGO:0042417 dopamine metabolic process IEA
 biological_processGO:0042551 neuron maturation IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043576 regulation of respiratory gaseous exchange IEA
 biological_processGO:0045444 fat cell differentiation ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0051866 general adaptation syndrome IEA
 biological_processGO:0060070 canonical Wnt signaling pathway TAS
 biological_processGO:0071376 cellular response to corticotropin-releasing hormone stimulus ISS
 biological_processGO:0071542 dopaminergic neuron differentiation ISS
 biological_processGO:1904948 midbrain dopaminergic neuron differentiation TAS
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding TAS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity TAS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046965 retinoid X receptor binding TAS
 molecular_functionGO:0046982 protein heterodimerization activity TAS


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000012 Urinary urgency 
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 HP:0000298 Mask-like facies 
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 HP:0000716 Depression "A condition characterized by pervasive dysphoric mood, loss of interests, and inability to experience pleasure." [HPO:curators]
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 HP:0000726 Dementia 
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 HP:0000738 Hallucinations 
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 HP:0000751 Personality changes 
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 HP:0001260 Dysarthria "Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed." [HPO:curators]
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 HP:0001300 Parkinsonism 
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 HP:0001332 Dystonia "An abnormally increased muscular tone that causes fixed abnormal postures. There is a slow, intermittent twisting motion that leads to exaggerated turning and posture of the extremities and trunk." [HPO:curators]
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 HP:0001337 Tremor "An unintentional, oscillating to-and-fro muscle movement." [HPO:curators]
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 HP:0001621 Soft voice 
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 HP:0002015 Dysphagia "Difficulty in swallowing." [HPO:curators]
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 HP:0002019 Constipation 
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 HP:0002063 Rigidity 
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 HP:0002067 Bradykinesia "Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement)." [HPO:curators]
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 HP:0002172 Postural instability 
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 HP:0002322 Resting tremor "A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse." [HPO:curators]
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 HP:0002360 Sleep disturbances "An abnormality of sleep including such phenomena as 1) insomnia/hypersomnia, 2) non-restorative sleep, 3) sleep schedule disorder, 4) excessive daytime somnolence, 5) sleep apnea, and 6) restlessness." [HPO:curators]
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 HP:0002459 Dysautonomia 
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 HP:0002529 Neuropathology shows neuronal loss in basal ganglia, brainstem, and cerebellum 
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 HP:0003587 Insidious onset 
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 HP:0003676 Progressive disorder 
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 HP:0003745 Sporadic 
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 HP:0007311 Short stepped shuffling gait 
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 HP:0011960 Substantia nigra gliosis "The presence of `gliosis` (MPATH:182) in the `substantia nigra` (FMA:67947)." [HPO:probinson]
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 HP:0100315 Lewy bodies 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction






 

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