ENSG00000123358


Homo sapiens

Features
Gene ID: ENSG00000123358
  
Biological name :NR4A1
  
Synonyms : NR4A1 / nuclear receptor subfamily 4 group A member 1 / P22736
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.13
Gene start: 52022832
Gene end: 52059507
  
Corresponding Affymetrix probe sets: 202340_x_at (Human Genome U133 Plus 2.0 Array)   210226_at (Human Genome U133 Plus 2.0 Array)   211143_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456776
Ensembl peptide - ENSP00000456633
Ensembl peptide - ENSP00000457070
Ensembl peptide - ENSP00000243050
Ensembl peptide - ENSP00000353427
Ensembl peptide - ENSP00000378301
Ensembl peptide - ENSP00000378302
Ensembl peptide - ENSP00000440864
Ensembl peptide - ENSP00000449539
Ensembl peptide - ENSP00000449587
Ensembl peptide - ENSP00000449858
Ensembl peptide - ENSP00000455399
Ensembl peptide - ENSP00000455767
NCBI entrez gene - 3164     See in Manteia.
OMIM - 139139
RefSeq - XM_017019247
RefSeq - NM_001202233
RefSeq - NM_001202234
RefSeq - NM_002135
RefSeq - NM_173157
RefSeq - XM_005268822
RefSeq - XM_005268824
RefSeq - XM_006719363
RefSeq - XM_006719364
RefSeq Peptide - NP_775180
RefSeq Peptide - NP_001189162
RefSeq Peptide - NP_001189163
RefSeq Peptide - NP_002126
swissprot - H3BT85
swissprot - F5GXF0
swissprot - F8VVX9
swissprot - H3BPN8
swissprot - H3BQG5
swissprot - H3BSB9
swissprot - P22736
swissprot - A0A024R126
swissprot - H3BSM8
Ensembl - ENSG00000123358
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr4a1ENSDARG00000000796Danio rerio
 Nr4a1ENSMUSG00000023034Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR4A2 / P43354 / nuclear receptor subfamily 4 group A member 2ENSG0000015323451
NR4A3 / Q92570 / nuclear receptor subfamily 4 group A member 3ENSG0000011950846
PGR / P06401 / progesterone receptorENSG0000008217520
NR3C2 / P08235 / nuclear receptor subfamily 3 group C member 2ENSG0000015162319
ESRRA / P11474 / estrogen related receptor alphaENSG0000017315319
ESRRG / P62508 / estrogen related receptor gammaENSG0000019648219
ESRRB / O95718 / estrogen related receptor betaENSG0000011971519
ESR2 / Q92731 / estrogen receptor 2ENSG0000014000919
ESR1 / P03372 / estrogen receptor 1ENSG0000009183118
NR3C1 / P04150 / nuclear receptor subfamily 3 group C member 1ENSG0000011358018
AR / P10275 / androgen receptorENSG0000016908316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003070  Orphan nuclear receptor
 IPR003071  Orphan nuclear receptor, HMR type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IMP
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0035767 endothelial cell chemotaxis IMP
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IMP
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043491 protein kinase B signaling TAS
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IMP
 biological_processGO:0045444 fat cell differentiation ISS
 biological_processGO:0045786 negative regulation of cell cycle ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0061469 regulation of type B pancreatic cell proliferation ISS
 biological_processGO:0071376 cellular response to corticotropin-releasing hormone stimulus ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0031965 nuclear membrane IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISS


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the nucleus
Nuclear Receptor transcription pathway
Constitutive Signaling by AKT1 E17K in Cancer


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction






 

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