ENSMUSG00000023034


Mus musculus

Features
Gene ID: ENSMUSG00000023034
  
Biological name :Nr4a1
  
Synonyms : Nr4a1 / nuclear receptor subfamily 4, group A, member 1 / P12813
  
Possible biological names infered from orthology : P22736
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F1
Gene start: 101254269
Gene end: 101274795
  
Corresponding Affymetrix probe sets: 10427035 (MoGene1.0st)   1416505_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023779
Ensembl peptide - ENSMUSP00000155056
Ensembl peptide - ENSMUSP00000155225
NCBI entrez gene - 15370     See in Manteia.
MGI - MGI:1352454
RefSeq - XM_017316436
RefSeq - NM_010444
RefSeq - XM_006520456
RefSeq - XM_006520458
RefSeq - XM_006520459
RefSeq - XM_006520455
RefSeq Peptide - NP_034574
swissprot - P12813
swissprot - Q545Q1
Ensembl - ENSMUSG00000023034
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr4a1ENSDARG00000000796Danio rerio
 NR4A1ENSG00000123358Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr4a2 / Q06219 / Nuclear receptor subfamily 4 group A member 2 / P43354*ENSMUSG0000002682653
Nr4a3 / Q9QZB6 / Nuclear receptor subfamily 4 group A member 3 / Q92570*ENSMUSG0000002834149
Esrra / O08580 / Steroid hormone receptor ERR1 / P11474* / estrogen related receptor alpha*ENSMUSG0000002495521
Esrrg / P62509 / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA. / P62508* / estrogen related receptor gamma*ENSMUSG0000002661021
Esrrb / Q61539 / Steroid hormone receptor ERR2 / O95718* / estrogen related receptor beta*ENSMUSG0000002125520
Nr3c2 / nuclear receptor subfamily 3 group C member 2 / P08235*ENSMUSG0000003161820
Esr2 / O08537 / Estrogen receptor beta / Q92731* / estrogen receptor 2*ENSMUSG0000002105520
Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*ENSMUSG0000001976820
Nr3c1 / nuclear receptor subfamily 3, group C, member 1 / P04150*ENSMUSG0000002443119
Pgr / Q00175 / Progesterone receptor / P06401*ENSMUSG0000003187019
Ar / P19091 / Androgen receptor / P10275*ENSMUSG0000004653217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003070  Orphan nuclear receptor
 IPR003071  Orphan nuclear receptor, HMR type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0010035 response to inorganic substance ISO
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0035767 endothelial cell chemotaxis ISO
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus ISO
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus ISO
 biological_processGO:0045444 fat cell differentiation IDA
 biological_processGO:0045786 negative regulation of cell cycle IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0061469 regulation of type B pancreatic cell proliferation ISS
 biological_processGO:0071310 cellular response to organic substance IDA
 biological_processGO:0071376 cellular response to corticotropin-releasing hormone stimulus IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0031965 nuclear membrane ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the nucleus
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001619 abnormal vascular permeability "anomaly in the ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: P2rx7P451L/P2rx7P451L
Genetic Background: C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Lyz2tm1(cre)Ifo/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Lyz2tm1(cre)Ifo/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009671 abnormal uterus physiology "any anomaly in normal cyclical changes not due to anatomical defect" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: P2rx7P451L/P2rx7P451L
Genetic Background: C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Plin1tm1Asg/Plin1tm1Asg,Tg(Fabp4-Plin*)1Asg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
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Allelic Composition: Klf4tm1Khk/Klf4tm1Khk,Lyz2tm1(cre)Ifo/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction






 

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