ENSMUSG00000021255


Mus musculus

Features
Gene ID: ENSMUSG00000021255
  
Biological name :Esrrb
  
Synonyms : Esrrb / Q61539 / Steroid hormone receptor ERR2
  
Possible biological names infered from orthology : estrogen related receptor beta / O95718
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D2
Gene start: 86361117
Gene end: 86521628
  
Corresponding Affymetrix probe sets: 10397440 (MoGene1.0st)   1422986_at (Mouse Genome 430 2.0 Array)   1436926_at (Mouse Genome 430 2.0 Array)   1441921_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112103
Ensembl peptide - ENSMUSP00000131335
Ensembl peptide - ENSMUSP00000021680
Ensembl peptide - ENSMUSP00000105832
Ensembl peptide - ENSMUSP00000105833
NCBI entrez gene - 26380     See in Manteia.
MGI - MGI:1346832
RefSeq - XM_006515881
RefSeq - XM_006515883
RefSeq - XM_006515882
RefSeq - NM_001159500
RefSeq - NM_011934
RefSeq Peptide - NP_001152972
RefSeq Peptide - NP_036064
swissprot - Q61539
swissprot - E9QKA2
swissprot - D3YW03
swissprot - G5E8P8
Ensembl - ENSMUSG00000021255
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 esrrbENSDARG00000100847Danio rerio
 ESRRBENSGALG00000041775Gallus gallus
 ESRRBENSG00000119715Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Esrrg / P62509 / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA. / P62508* / estrogen related receptor gamma*ENSMUSG0000002661075
Esrra / O08580 / Steroid hormone receptor ERR1 / P11474* / estrogen related receptor alpha*ENSMUSG0000002495555
Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*ENSMUSG0000001976833
Esr2 / O08537 / Estrogen receptor beta / Q92731* / estrogen receptor 2*ENSMUSG0000002105531
Nr4a1 / P12813 / nuclear receptor subfamily 4, group A, member 1 / P22736*ENSMUSG0000002303427
Nr3c2 / nuclear receptor subfamily 3 group C member 2 / P08235*ENSMUSG0000003161826
Nr3c1 / nuclear receptor subfamily 3, group C, member 1 / P04150*ENSMUSG0000002443126
Nr4a2 / Q06219 / Nuclear receptor subfamily 4 group A member 2 / P43354*ENSMUSG0000002682625
Pgr / Q00175 / Progesterone receptor / P06401*ENSMUSG0000003187025
Nr4a3 / Q9QZB6 / Nuclear receptor subfamily 4 group A member 3 / Q92570*ENSMUSG0000002834124
Ar / P19091 / Androgen receptor / P10275*ENSMUSG0000004653223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR024178  Oestrogen receptor/oestrogen-related receptor
 IPR027289  Oestrogen-related receptor
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001831 trophectodermal cellular morphogenesis IMP
 biological_processGO:0001834 trophectodermal cell proliferation IMP
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0017145 stem cell division IMP
 biological_processGO:0019827 stem cell population maintenance IDA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043697 cell dedifferentiation IDA
 biological_processGO:0045494 photoreceptor cell maintenance IMP
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IDA
 biological_processGO:0045821 positive regulation of glycolytic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle IMP
 biological_processGO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle IMP
 biological_processGO:1902459 positive regulation of stem cell population maintenance IMP
 biological_processGO:2000035 regulation of stem cell division IMP
 biological_processGO:2000737 negative regulation of stem cell differentiation IMP
 cellular_componentGO:0000793 condensed chromosome IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032039 integrator complex IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000993 RNA polymerase II core binding IDA
 molecular_functionGO:0001047 core promoter binding IMP
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding ISS
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IMP
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0035326 enhancer binding IMP
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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 MP:0001711 abnormal placenta 
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 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0003169 abnormal scala media morphology "any malformation or absence of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [J:23837, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
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 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0004758 absent strial marginal cells "absence or loss of the polarized columnar cells of epithelial origin which cover the lateral surface of the cochlear duct, secrete potassium ions and form a continuous sheet in contact with the endolymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0004887 decreased endolymph production "reduced synthesis of the fluid that is normally contained within the membranous labyrinth of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0008308 small scala media "reduced size of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0008488 abnormal semicircular canal ampulla morphology "any structural anomaly of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0009593 absent chorion "absence of the outermost extraembryonic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

Allelic Composition: Esrrbtm1.1Nat/Esrrbtm1.2Nat,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0012100 absent spongiotrophoblast "absence of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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 MP:0012557 decreased calcium uptake by cardiac muscle "decreased directed movement of calcium ions into cardiac muscle; decreased or disrupted uptake may give rise to energetic deficit and oxidative stress. leading to cardiac disease" [http://orcid.org/0000-0001-5208-3432, PMID:22902320]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

 MP:0012558 increased calcium uptake by cardiac muscle "increased directed movement of calcium ions into the cardiac muscle; increased mitochondrial calcium ion uptake can trigger programmed necrosis in cardiac muscle" [http://orcid.org/0000-0001-5208-3432, PMID:22902320]
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Allelic Composition: Egfrwa2/Egfrwa2
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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