ENSMUSG00000026610


Mus musculus

Features
Gene ID: ENSMUSG00000026610
  
Biological name :Esrrg
  
Synonyms : Esrrg / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA. / P62509
  
Possible biological names infered from orthology : estrogen related receptor gamma / P62508
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H5
Gene start: 187608791
Gene end: 188214885
  
Corresponding Affymetrix probe sets: 10352576 (MoGene1.0st)   1421747_at (Mouse Genome 430 2.0 Array)   1455267_at (Mouse Genome 430 2.0 Array)   1457896_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027906
Ensembl peptide - ENSMUSP00000106563
Ensembl peptide - ENSMUSP00000106564
Ensembl peptide - ENSMUSP00000119286
NCBI entrez gene - 26381     See in Manteia.
MGI - MGI:1347056
RefSeq - XM_011238920
RefSeq - NM_001243792
RefSeq - NM_001357534
RefSeq - NM_001357535
RefSeq - NM_001357536
RefSeq - NM_011935
RefSeq - XM_006497170
RefSeq - XM_011238914
RefSeq - XM_011238915
RefSeq - XM_011238916
RefSeq - XM_011238917
RefSeq - XM_011238918
RefSeq - XM_011238919
RefSeq - XM_006497164
RefSeq - XM_006497165
RefSeq - XM_006497167
RefSeq Peptide - NP_001230721
RefSeq Peptide - NP_001344463
RefSeq Peptide - NP_001344464
RefSeq Peptide - NP_001344465
RefSeq Peptide - NP_036065
swissprot - P62509
swissprot - D3Z2J0
Ensembl - ENSMUSG00000026610
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO681288.3ENSDARG00000111043Danio rerio
 ESRRGENSGALG00000009645Gallus gallus
 ESRRGENSG00000196482Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Esrrb / Q61539 / Steroid hormone receptor ERR2 / O95718* / estrogen related receptor beta*ENSMUSG0000002125574
Esrra / O08580 / Steroid hormone receptor ERR1 / P11474* / estrogen related receptor alpha*ENSMUSG0000002495555
Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*ENSMUSG0000001976835
Esr2 / O08537 / Estrogen receptor beta / Q92731* / estrogen receptor 2*ENSMUSG0000002105532
Nr4a1 / P12813 / nuclear receptor subfamily 4, group A, member 1 / P22736*ENSMUSG0000002303428
Nr4a2 / Q06219 / Nuclear receptor subfamily 4 group A member 2 / P43354*ENSMUSG0000002682627
Nr3c1 / nuclear receptor subfamily 3, group C, member 1 / P04150*ENSMUSG0000002443126
Nr3c2 / nuclear receptor subfamily 3 group C member 2 / P08235*ENSMUSG0000003161825
Nr4a3 / Q9QZB6 / Nuclear receptor subfamily 4 group A member 3 / Q92570*ENSMUSG0000002834125
Pgr / Q00175 / Progesterone receptor / P06401*ENSMUSG0000003187024
Ar / P19091 / Androgen receptor / P10275*ENSMUSG0000004653223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003078  Retinoic acid receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR024178  Oestrogen receptor/oestrogen-related receptor
 IPR027289  Oestrogen-related receptor
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development NAS
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048384 retinoic acid receptor signaling pathway IEA
 cellular_componentGO:0005634 nucleus NAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0003708 retinoic acid receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity NAS
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding NAS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003014 abnormal kidney medulla morphology "anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(LDLR/avidin)Svo/Gt(ROSA)26Sortm1(LDLR/avidin)Svo
Genetic Background: involves: 129/Sv

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: involves: 129P2/OlaHsd

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: involves: 129P2/OlaHsd

 MP:0004193 abnormal kidney papilla morphology "any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(LDLR/avidin)Svo/Gt(ROSA)26Sortm1(LDLR/avidin)Svo
Genetic Background: involves: 129/Sv

 MP:0004194 abnormal kidney pelvis morphology "any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(LDLR/avidin)Svo/Gt(ROSA)26Sortm1(LDLR/avidin)Svo
Genetic Background: involves: 129/Sv

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: involves: 129P2/OlaHsd

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(LDLR/avidin)Svo/Gt(ROSA)26Sortm1(LDLR/avidin)Svo
Genetic Background: involves: 129/Sv

 MP:0005604 hyperekplexia "disorder characterized by pathologic startle responses, protective reactions to unanticipated, potentially threatening, stimuli of any type, particularly auditory" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: involves: 129P2/OlaHsd

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: involves: 129P2/OlaHsd

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esrrgtm1Rev/Esrrg+
Genetic Background: either: (involves: 129) or (involves: C57BL/6) or (involves: ICR)

 MP:0010570 prolonged ST segment "increase in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: involves: 129P2/OlaHsd

 MP:0010636 bundle branch block "intraventricular block resulting from an interruption or partial or complete block of conduction in one of the two atrioventricular bundle branches; a prolonged QRS complex seen on an ECG indicates defects in bundle branch conduction; blocks in each branch result in a distinct QRS ECG waveform morphology" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Esrrgtm1Rev/Esrrg+
Genetic Background: either: (involves: 129) or (involves: C57BL/6) or (involves: ICR)

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic Background: involves: 129P2/OlaHsd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Esrrgtm1Rev/Esrrgtm1Rev
Genetic Background: either: (involves: 129) or (involves: C57BL/6) or (involves: ICR)

Allelic Composition: Esrrgtm1Rev/Esrrgtm1Rev
Genetic Background: involves: C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011303 absent kidney papilla "absence of the apex (tip) of a renal pyramid i.e. the location where each medullary pyramid empties urine into a minor calyx" [MGI:anna]
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Allelic Composition: Gt(ROSA)26Sortm1(LDLR/avidin)Svo/Gt(ROSA)26Sortm1(LDLR/avidin)Svo
Genetic Background: involves: 129/Sv

 MP:0011628 increased mitochondria number "greater than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Esrrgtm1Rev/Esrrgtm1Rev
Genetic Background: either: (involves: 129) or (involves: C57BL/6) or (involves: ICR)

Allelic Composition: Esrrgtm1Rev/Esrrg+
Genetic Background: either: (involves: 129) or (involves: C57BL/6) or (involves: ICR)

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0013405 increased circulating lactate level "greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
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Allelic Composition: Esrrgtm1Rev/Esrrgtm1Rev
Genetic Background: either: (involves: 129) or (involves: C57BL/6) or (involves: ICR)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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