ENSMUSG00000031618


Mus musculus

Features
Gene ID: ENSMUSG00000031618
  
Biological name :Nr3c2
  
Synonyms : Nr3c2 / nuclear receptor subfamily 3 group C member 2
  
Possible biological names infered from orthology : P08235
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C1
Gene start: 76899442
Gene end: 77245012
  
Corresponding Affymetrix probe sets: 10572949 (MoGene1.0st)   1435991_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034031
Ensembl peptide - ENSMUSP00000122959
Ensembl peptide - ENSMUSP00000118222
Ensembl peptide - ENSMUSP00000116008
Ensembl peptide - ENSMUSP00000105539
Ensembl peptide - ENSMUSP00000105538
Ensembl peptide - ENSMUSP00000105537
NCBI entrez gene - 110784     See in Manteia.
MGI - MGI:99459
RefSeq - XM_006530577
RefSeq - NM_001083906
RefSeq - XM_006530574
RefSeq - XM_006530575
RefSeq - XM_006530576
RefSeq Peptide - NP_001077375
swissprot - E9Q8M8
swissprot - D6RIL1
swissprot - D3Z7F2
swissprot - D3Z473
swissprot - A3KN90
swissprot - D3Z7J4
Ensembl - ENSMUSG00000031618
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr3c2ENSDARG00000102082Danio rerio
 NR3C2ENSGALG00000010035Gallus gallus
 NR3C2ENSG00000151623Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr3c1 / nuclear receptor subfamily 3, group C, member 1 / P04150*ENSMUSG0000002443132
Pgr / Q00175 / Progesterone receptor / P06401*ENSMUSG0000003187030
Ar / P19091 / Androgen receptor / P10275*ENSMUSG0000004653226
Esr2 / O08537 / Estrogen receptor beta / Q92731* / estrogen receptor 2*ENSMUSG0000002105514
Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*ENSMUSG0000001976813
Esrrb / Q61539 / Steroid hormone receptor ERR2 / O95718* / estrogen related receptor beta*ENSMUSG0000002125512
Nr4a1 / P12813 / nuclear receptor subfamily 4, group A, member 1 / P22736*ENSMUSG0000002303412
Nr4a3 / Q9QZB6 / Nuclear receptor subfamily 4 group A member 3 / Q92570*ENSMUSG0000002834112
Esrra / O08580 / Steroid hormone receptor ERR1 / P11474* / estrogen related receptor alpha*ENSMUSG0000002495512
Esrrg / P62509 / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA. / P62508* / estrogen related receptor gamma*ENSMUSG0000002661012
Nr4a2 / Q06219 / Nuclear receptor subfamily 4 group A member 2 / P43354*ENSMUSG0000002682612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000250 abnormal vasoconstriction "anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igkctm1(IGKC)Mnz/Igktm4.1Wtg
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: LmnaGt(S7-1F1)Sor/Lmna+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igkctm1(IGKC)Mnz/Igktm4.1Wtg
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0001765 abnormal ion homeostasis "anomaly in the state of equilibrium in the body with respect to charged molecules in the fluids and tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nr3c2tm2Gsc/Nr3c2tm2Gsc,Tg(Aqp2-cre/ERT2)4Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0002829 abnormal juxtaglomerular apparatus "anomalous structure or development of the complex of modified smooth muscle cells consisting of juxtaglomerular cells, extraglomerular mesangium lacis cells, the macula densa of the distal convoluted tubule, and granular epithelial peripolar cells; these cells are found in the walls of afferent and efferent glomerular arterioles" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Igkctm1(IGKC)Mnz/Igktm4.1Wtg
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Igkctm1(IGKC)Mnz/Igktm4.1Wtg
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Igkctm1(IGKC)Mnz/Igktm4.1Wtg
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igkctm1(IGKC)Mnz/Igktm4.1Wtg
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0004142 abnormal muscle tone "anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Igkctm1(IGKC)Mnz/Igktm4.1Wtg
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005582 increased renin activity "greater than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igkctm1(IGKC)Mnz/Igktm4.1Wtg
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005634 decreased circulating sodium level "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Igkctm1(IGKC)Mnz/Igktm4.1Wtg
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nr3c2tm2Gsc/Nr3c2tm2Gsc,Tg(Aqp2-cre/ERT2)4Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0010109 abnormal renal sodium reabsorption "any anomaly in the process by which sodium ions are transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010128 hypovolemia "an abnormally decreased amount of space occupied by blood in the vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011299 abnormal macula densa morphology "any structural anomaly of the specialized group of densely packed epithelial cells marking the origin of the convoluted portion of the distal tubule of a nephron, in contact with the afferent arteriole of the renal corpuscle and contiguous with the juxtaglomerular cells; these cells are tall, thin and columnar, have prominent nuclei, and act as sensors of solute concentration and flow of tubular fluid" [MGI:anna]
Show

Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011300 abnormal juxtaglomerular cell morphology "any structural anomaly of the specialized smooth muscle cells that synthesize, store, and secrete renin and are found in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa; J-G cells are distinguished by their granulated cytoplasm and play a critical role in the renin-angiotensin system and thus in renal autoregulation" [MGI:anna]
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Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011302 abnormal extraglomerular mesangial cell morphology "any structural anomaly of the light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa; lacis cells form the juxtaglomerular apparatus in combination with two other types of cells: the macula densa of the distal convoluted tubule and juxtaglomerular cells of the afferent arteriole" [MGI:anna]
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Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011442 abnormal renal sodium ion transport "any anomaly in the directed movement of sodium ions (Na+) by the kidney" [GO:0003096]
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Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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