ENSGALG00000010035


Gallus gallus

Features
Gene ID: ENSGALG00000010035
  
Biological name :NR3C2
  
Synonyms : mineralocorticoid receptor / NR3C2
  
Possible biological names infered from orthology : nuclear receptor subfamily 3 group C member 2 / P08235
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 32373150
Gene end: 32574446
  
Corresponding Affymetrix probe sets: Gga.77.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000016283
Ensembl peptide - ENSGALP00000047395
Ensembl peptide - ENSGALP00000058137
NCBI entrez gene - 374131     See in Manteia.
RefSeq - XM_015276102
RefSeq - NM_001159345
RefSeq - XM_015276099
RefSeq - XM_015276101
RefSeq Peptide - NP_001152817
swissprot - G1K325
Ensembl - ENSGALG00000010035
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr3c2ENSDARG00000102082Danio rerio
 NR3C2ENSG00000151623Homo sapiens
 Nr3c2ENSMUSG00000031618Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR3C1 / glucocorticoid receptor / P04150* / nuclear receptor subfamily 3 group C member 1*ENSGALG0000003299231
PGR / progesterone receptor / P06401* / Q00175*ENSGALG0000001719527
AR / androgen receptor / P10275* / P19091*ENSGALG0000003087922
ESR1 / estrogen receptor / P03372* / P19785* / estrogen receptor 1*ENSGALG0000001297313
ESRRB / estrogen related receptor beta / O95718* / Q61539* / Steroid hormone receptor ERR2 *ENSGALG0000004177513
NR4A3 / nuclear receptor subfamily 4 group A member 3 / Q92570* / Q9QZB6*ENSGALG0000001356813
NR4A2 / nuclear receptor subfamily 4 group A member 2 / P43354* / Q06219*ENSGALG0000001253812
ESR2 / estrogen receptor beta / O08537* / Q92731* / estrogen receptor 2*ENSGALG0000001180112
ESRRG / estrogen-related receptor gamma / P62508* / P62509* / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA.*ENSGALG0000000964512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030252 growth hormone secretion IDA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0051459 regulation of corticotropin secretion IMP
 biological_processGO:0060126 somatotropin secreting cell differentiation IMP
 biological_processGO:0071376 cellular response to corticotropin-releasing hormone stimulus IDA
 biological_processGO:0071386 cellular response to corticosterone stimulus IDA
 biological_processGO:1904045 cellular response to aldosterone IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990239 steroid hormone binding IDA


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014331 FKBP4 / peptidyl-prolyl cis-trans isomerase FKBP4 / P30416* / Q02790* / FK506 binding protein 4* / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-te...  / complex
 ENSGALG00000036837 PTGES3 / prostaglandin E synthase 3 / Q15185* / Q9R0Q7*  / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000010175 HSP90AB1 / heat shock cognate protein HSP 90-beta / P08238* / P11499* / Heat shock protein HSP 90-beta * / heat shock protein 90 alpha family class B member 1*  / complex






 

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