ENSGALG00000032992


Gallus gallus

Features
Gene ID: ENSGALG00000032992
  
Biological name :NR3C1
  
Synonyms : glucocorticoid receptor / NR3C1
  
Possible biological names infered from orthology : nuclear receptor subfamily 3 group C member 1 / P04150
  
Species: Gallus gallus
  
Chr. number: 13
Strand: -1
Band:
Gene start: 17485533
Gene end: 17536237
  
Corresponding Affymetrix probe sets: Gga.128.1.S1_at (Chicken Array)   Gga.171.1.S1_s_at (Chicken Array)   GgaAffx.22235.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050500
Ensembl peptide - ENSGALP00000055461
Ensembl peptide - ENSGALP00000052544
NCBI entrez gene - 416343     See in Manteia.
RefSeq - NM_001037826
RefSeq - XM_015294033
RefSeq Peptide - NP_001032915
swissprot - A0A1D5PRD7
swissprot - A0A1D5PIB1
swissprot - A0A1D5PCL1
Ensembl - ENSGALG00000032992
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nr3c1ENSDARG00000025032Danio rerio
 NR3C1ENSG00000113580Homo sapiens
 Nr3c1ENSMUSG00000024431Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NR3C2 / mineralocorticoid receptor / P08235* / nuclear receptor subfamily 3 group C member 2*ENSGALG0000001003540
PGR / progesterone receptor / P06401* / Q00175*ENSGALG0000001719532
AR / androgen receptor / P10275* / P19091*ENSGALG0000003087927
ESR1 / estrogen receptor / P03372* / P19785* / estrogen receptor 1*ENSGALG0000001297316
ESR2 / estrogen receptor beta / O08537* / Q92731* / estrogen receptor 2*ENSGALG0000001180115
ESRRG / estrogen-related receptor gamma / P62508* / P62509* / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA.*ENSGALG0000000964515
ESRRB / estrogen related receptor beta / O95718* / Q61539* / Steroid hormone receptor ERR2 *ENSGALG0000004177515
NR4A2 / nuclear receptor subfamily 4 group A member 2 / P43354* / Q06219*ENSGALG0000001253814
NR4A3 / nuclear receptor subfamily 4 group A member 3 / Q92570* / Q9QZB6*ENSGALG0000001356812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001409  Glucocorticoid receptor
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009408 response to heat IDA
 biological_processGO:0030252 growth hormone secretion IDA
 biological_processGO:0042921 glucocorticoid receptor signaling pathway IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043402 glucocorticoid mediated signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051459 regulation of corticotropin secretion IMP
 biological_processGO:0060126 somatotropin secreting cell differentiation IMP
 biological_processGO:0071376 cellular response to corticotropin-releasing hormone stimulus IDA
 biological_processGO:0071383 cellular response to steroid hormone stimulus IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IEA
 biological_processGO:0071386 cellular response to corticosterone stimulus IDA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:1904045 cellular response to aldosterone IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004883 glucocorticoid receptor activity IEA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0032183 SUMO binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA
 molecular_functionGO:1990239 steroid hormone binding IEA


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000014331 FKBP4 / peptidyl-prolyl cis-trans isomerase FKBP4 / P30416* / Q02790* / FK506 binding protein 4* / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-te...  / complex
 ENSGALG00000010175 HSP90AB1 / heat shock cognate protein HSP 90-beta / P08238* / P11499* / Heat shock protein HSP 90-beta * / heat shock protein 90 alpha family class B member 1*  / complex
 ENSGALG00000032992 NR3C1 / glucocorticoid receptor / P04150* / nuclear receptor subfamily 3 group C member 1*  / complex
 ENSGALG00000036837 PTGES3 / prostaglandin E synthase 3 / Q15185* / Q9R0Q7*  / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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