ENSGALG00000012973


Gallus gallus

Features
Gene ID: ENSGALG00000012973
  
Biological name :ESR1
  
Synonyms : ESR1 / estrogen receptor
  
Possible biological names infered from orthology : estrogen receptor 1 / P03372 / P19785
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 49187155
Gene end: 49301908
  
Corresponding Affymetrix probe sets: Gga.650.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000021137
NCBI entrez gene - 396099     See in Manteia.
RefSeq - NM_205183
RefSeq - XM_015284050
RefSeq Peptide - NP_990514
swissprot - E5L8C9
Ensembl - ENSGALG00000012973
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 esr1ENSDARG00000004111Danio rerio
 ESR1ENSG00000091831Homo sapiens
 Esr1ENSMUSG00000019768Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ESR2 / estrogen receptor beta / O08537* / Q92731* / estrogen receptor 2*ENSGALG0000001180140
ESRRG / estrogen-related receptor gamma / P62508* / P62509* / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA.*ENSGALG0000000964527
ESRRB / estrogen related receptor beta / O95718* / Q61539* / Steroid hormone receptor ERR2 *ENSGALG0000004177526
NR3C1 / glucocorticoid receptor / P04150* / nuclear receptor subfamily 3 group C member 1*ENSGALG0000003299221
NR3C2 / mineralocorticoid receptor / P08235* / nuclear receptor subfamily 3 group C member 2*ENSGALG0000001003521
NR4A2 / nuclear receptor subfamily 4 group A member 2 / P43354* / Q06219*ENSGALG0000001253820
PGR / progesterone receptor / P06401* / Q00175*ENSGALG0000001719520
NR4A3 / nuclear receptor subfamily 4 group A member 3 / Q92570* / Q9QZB6*ENSGALG0000001356819
AR / androgen receptor / P10275* / P19091*ENSGALG0000003087917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001292  Oestrogen receptor
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR024178  Oestrogen receptor/oestrogen-related receptor
 IPR024736  Oestrogen-type nuclear receptor final C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001547 antral ovarian follicle growth IEA
 biological_processGO:0002064 epithelial cell development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008209 androgen metabolic process IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0034121 regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048863 stem cell differentiation IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060065 uterus development IEA
 biological_processGO:0060068 vagina development IEA
 biological_processGO:0060523 prostate epithelial cord elongation IEA
 biological_processGO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
 biological_processGO:0060687 regulation of branching involved in prostate gland morphogenesis IEA
 biological_processGO:0060745 mammary gland branching involved in pregnancy IEA
 biological_processGO:0060749 mammary gland alveolus development IEA
 biological_processGO:0060750 epithelial cell proliferation involved in mammary gland duct elongation IEA
 biological_processGO:0071168 protein localization to chromatin IEA
 biological_processGO:0071391 cellular response to estrogen stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035327 transcriptionally active chromatin IEA
 cellular_componentGO:0097550 transcriptional preinitiation complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001093 TFIIB-class transcription factor binding IEA
 molecular_functionGO:0001223 transcription coactivator binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0017025 TBP-class protein binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030284 estrogen receptor activity IDA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0034056 estrogen response element binding IEA
 molecular_functionGO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IPI


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
PIP3 activates AKT signaling
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Ovarian tumor domain proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
RUNX1 regulates estrogen receptor mediated transcription
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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