Manteia - Molecule gene

ENSMUSG00000024431

Mus musculus

Features

Gene ID:	ENSMUSG00000024431

Biological name :	Nr3c1

Synonyms :	Nr3c1 / nuclear receptor subfamily 3, group C, member 1

Possible biological names infered from orthology :	P04150

Species:	Mus musculus

Chr. number:	18
Strand:	-1
Band:	B3
Gene start:	39410545
Gene end:	39491301

Corresponding Affymetrix probe sets:	10458569 (MoGene1.0st) 1421866_at (Mouse Genome 430 2.0 Array) 1421867_at (Mouse Genome 430 2.0 Array) 1431378_at (Mouse Genome 430 2.0 Array) 1453860_s_at (Mouse Genome 430 2.0 Array) 1457635_s_at (Mouse Genome 430 2.0 Array) 1460303_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000095199 Ensembl peptide - ENSMUSP00000111229 Ensembl peptide - ENSMUSP00000121144 Ensembl peptide - ENSMUSP00000120082 Ensembl peptide - ENSMUSP00000119630 Ensembl peptide - ENSMUSP00000119432 Ensembl peptide - ENSMUSP00000111233 Ensembl peptide - ENSMUSP00000025300 NCBI entrez gene - 14815 See in Manteia. MGI - MGI:95824 RefSeq - XM_017317838 RefSeq - XM_006525663 RefSeq - XM_006525664 RefSeq - XM_006525665 RefSeq - XM_006525666 RefSeq - XM_017317835 RefSeq - XM_017317836 RefSeq - XM_017317837 RefSeq - NM_008173 RefSeq - XM_006525658 RefSeq - XM_006525659 RefSeq - XM_006525660 RefSeq - XM_006525661 RefSeq - XM_006525662 RefSeq Peptide - NP_032199 swissprot - E9PYV1 swissprot - E9PUR6 swissprot - E9Q310 swissprot - D3YTK8 swissprot - E9Q8A6 swissprot - D3Z280 Ensembl - ENSMUSG00000024431

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nr3c1	ENSDARG00000025032	Danio rerio
NR3C1	ENSGALG00000032992	Gallus gallus
NR3C1	ENSG00000113580	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Nr3c2 / nuclear receptor subfamily 3 group C member 2 / P08235*	ENSMUSG00000031618	40
Pgr / Q00175 / Progesterone receptor / P06401*	ENSMUSG00000031870	34
Ar / P19091 / Androgen receptor / P10275*	ENSMUSG00000046532	30
Esr2 / O08537 / Estrogen receptor beta / Q92731* / estrogen receptor 2*	ENSMUSG00000021055	16
Nr4a1 / P12813 / nuclear receptor subfamily 4, group A, member 1 / P22736*	ENSMUSG00000023034	15
Esrrb / Q61539 / Steroid hormone receptor ERR2 / O95718* / estrogen related receptor beta*	ENSMUSG00000021255	15
Esrrg / P62509 / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA. / P62508* / estrogen related receptor gamma*	ENSMUSG00000026610	15
Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*	ENSMUSG00000019768	15
Esrra / O08580 / Steroid hormone receptor ERR1 / P11474* / estrogen related receptor alpha*	ENSMUSG00000024955	15
Nr4a2 / Q06219 / Nuclear receptor subfamily 4 group A member 2 / P43354*	ENSMUSG00000026826	14
Nr4a3 / Q9QZB6 / Nuclear receptor subfamily 4 group A member 3 / Q92570*	ENSMUSG00000028341	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR000536	Nuclear hormone receptor, ligand-binding domain
IPR001409	Glucocorticoid receptor
IPR001628	Zinc finger, nuclear hormone receptor-type
IPR001723	Nuclear hormone receptor
IPR011989	Armadillo-like helical
IPR013088	Zinc finger, NHR/GATA-type
IPR035500	Nuclear hormone receptor-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0042921	glucocorticoid receptor signaling pathway	IEA
biological_process	GO:0043401	steroid hormone mediated signaling pathway	IEA
biological_process	GO:0043402	glucocorticoid mediated signaling pathway	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0071383	cellular response to steroid hormone stimulus	IEA
biological_process	GO:0071385	cellular response to glucocorticoid stimulus	IEA
biological_process	GO:0071549	cellular response to dexamethasone stimulus	IEA
biological_process	GO:0071560	cellular response to transforming growth factor beta stimulus	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0016607	nuclear speck	IEA
cellular_component	GO:0032991	protein-containing complex	IEA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0001047	core promoter binding	IEA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0003707	steroid hormone receptor activity	IEA
molecular_function	GO:0004883	glucocorticoid receptor activity	IEA
molecular_function	GO:0005496	steroid binding	IEA
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0019901	protein kinase binding	IEA
molecular_function	GO:0032183	SUMO binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0051879	Hsp90 protein binding	IEA
molecular_function	GO:1990239	steroid hormone binding	IEA

Pathways (from Reactome)

Pathway description

HSP90 chaperone cycle for steroid hormone receptors (SHR)

Nuclear Receptor transcription pathway

SUMOylation of intracellular receptors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000013	abnormal fat distribution	"alterations in the normal placement and amount of body fat" [J:57315]	Show Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Tg(Runx2-icre)1Jtuc/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0000066	osteoporosis	"reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kmt2a^{tm2(MLLT3)Thr}/Kmt2a⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0000494	abnormal cecum morphology	"malformation of the large sac at the ileum and large intestine junction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^W-42J/Kit⁺,X/Sry^POS-TIR Genetic Background: involves: C57BL/6J
MP:0000609	abnormal liver physiology	"aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000639	abnormal adrenal gland morphology	"malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]	Show Allelic Composition: Cblb^tm1Pngr/Cblb^tm1Pngr Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺ Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs}
MP:0000642	enlarged adrenal glands	"increased size of the endocrine gland" [J:40203]	Show Allelic Composition: Cblb^tm1Pngr/Cblb^tm1Pngr Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺ Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs}
MP:0000643	absent central medulla	"missing marrow like structure; cells here are responsible for secretion of epinephrine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Cblb^tm1Pngr/Cblb^tm1Pngr Genetic Background: involves: 129 * C57BL/6
MP:0000645	absent adrenergic chromaffin cells	"missing cells responsible for epinephrine and norepinephrine secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:54931]	Show Allelic Composition: Cblb^tm1Pngr/Cblb^tm1Pngr Genetic Background: involves: 129 * C57BL/6
MP:0000646	enlarged adrenocortical cells	"larger size of cells of the adrenal gland " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Cblb^tm1Pngr/Cblb^tm1Pngr Genetic Background: involves: 129 * C57BL/6
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Lpl^tm1Sem/Lpl⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0001176	abnormal lung development	"malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Lpl^tm1Sem/Lpl⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
MP:0001177	atelectasis	"collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001179	thicker alveolar septa		Show Allelic Composition: Lpl^tm1Sem/Lpl⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
MP:0001257	increased body length	"increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt2a^{tm2(MLLT3)Thr}/Kmt2a⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Tg(Alb1-cre)7Gsc/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Stat5a^tm2Mam/Stat5a^tm2Mam,Stat5b^tm1Mam/Stat5b^tm1Mam,Tg(Alb1-cre)7Gsc/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Stat5b^tm1Mam/Stat5b^tm1Mam,Tg(Alb1-cre)7Gsc/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N Allelic Composition: Nr3c1^tm1.1Mvc/Nr3c1⁺,Tg(Sim1-cre)1Lowl/0 Genetic Background: involves: 129 * C57BL/6 * FVB
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Agrn^tm3Jrs/Agrn^tm3Jrs Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001625	cardiac hypertrophy	"an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0001633	poor circulation	"insufficient movement of blood throughout the body" [MGI:cls, J:45302]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0001742	absent circulating adrenaline	"lack of a catacholamine hormone that stimulates the adrenergic receptors and causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:24414]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Nr3c1^tm2.1Gsc/Nr3c1^tm2.1Gsc Genetic Background: involves: 129P2/OlaHsd
MP:0001745	increased circulating corticosterone level	"greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]	Show Allelic Composition: Notch1^tm1Rko/Notch1^tm1Rko Genetic Background: involves: 129X1/SvJ Allelic Composition: Nr3c1^tm2Ljm/Nr3c1^tm2Ljm,Tg(Camk2a-cre)T50Stl/? Genetic Background: involves: 129 * BALB/c * C57BL/6 * CBA Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Tg(Camk2a-cre/ERT2)2Gsc/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺ Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs} Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv Allelic Composition: Nr3c1^tm1.1Mvc/Nr3c1⁺,Tg(Sim1-cre)1Lowl/0 Genetic Background: involves: 129 * C57BL/6 * FVB
MP:0001748	increased circulating adrenocorticotropin level	"elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nr3c1^tm1.1Mvc/Nr3c1⁺,Tg(Sim1-cre)1Lowl/0 Genetic Background: involves: 129 * C57BL/6 * FVB
MP:0001753	hypersecretion of corticotropin-releasing hormone	"excessive release of this factor, which normally stimulates the pituitary to release adrenocorticotropic hormone, from the hypothalamus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv
MP:0001800	abnormal humoral immune response	"abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda,Tcra^tm1Mom/Tcra^tm1Mom,Tg(Lck-cre)548Jxm/0 Genetic Background: B6.Cg-Tcra^tm1Mom Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda,Tcra^tm1Mom/Tcra^tm1Mom,Tg(Lck-cre)548Jxm/0 Genetic Background: B6.Cg-Tcra^tm1Mom Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm
MP:0001853	heart inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0001855	atrial thrombosis	"formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0001899	absent long term depression	"lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^tm2Ljm/Nr3c1^tm2Ljm,Tg(Camk2a-cre)T50Stl/? Genetic Background: involves: 129 * BALB/c * C57BL/6 * CBA
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Lpl^tm1Sem/Lpl⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0002065	abnormal fear/anxiety-related behavior	"altered response in tests for fear or anxiety related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcb4^tm1Bor/Abcb4^tm1Bor Genetic Background: C.129P2-Abcb4^tm1Bor
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Spry2^tm1Mrt/Spry2^tm1Mrt Genetic Background: involves: 129P2/OlaHsd
MP:0002270	abnormal alveoli morphology	"any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
MP:0002272	abnormal nervous system electrophysiology	"anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Csnk1d^{Gt(TEA020)Byg}/Csnk1d⁺,Tg(PER2S662D)382Ljp/0 Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Tg(Drd1a-cre)AGsc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0002273	abnormal alveolar epithelial cell morphology	"any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
MP:0002324	abnormal blood-air barrier	"anomaly in the membrane between the capillary blood and alveolar air, comprised of the alveolar epithelium and the capillary epithelium and their adherent basement membranes and epithelial cell cytoplasm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
MP:0002573	behavioral despair	"depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]	Show Allelic Composition: Agrn^tm3Jrs/Agrn^tm3Jrs Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002664	decreased circulating adrenocorticotropin level	"decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv Allelic Composition: Nr3c1^tm1Dage/Nr3c1^tm1Dage Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL Allelic Composition: Nr3c1^tm1Dage/Nr3c1⁺ Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL
MP:0002665	decreased circulating corticosterone level	"less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Neu1^a/Neu1^a Genetic Background: B6.SM-Neu1^a Allelic Composition: Nr3c1^tm1Dage/Nr3c1⁺ Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL
MP:0002666	increased circulating aldosterone level	"increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺ Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs}
MP:0002753	dilated left ventricle	"an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0002768	small adrenal glands	"reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]	Show Allelic Composition: Nr3c1^tm1Dage/Nr3c1^tm1Dage Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL Allelic Composition: Nr3c1^tm1Dage/Nr3c1⁺ Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nr3c1^tm1Dage/Nr3c1^tm1Dage Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL Allelic Composition: Nr3c1^tm1Dage/Nr3c1⁺ Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0002953	thick ventricular wall	"increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0003075	response to CNS ischemic injury		Show Allelic Composition: Nr3c1^tm2.1Ljm/Nr3c1^tm2.1Ljm,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac Allelic Composition: Nr3c1^tm2.1Ljm/Nr3c1^tm2.1Ljm,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL
MP:0003115	abnormal respiratory system development	"aberrant differentiation of pulmonary tissues" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0003367	increased circulating glucocorticoid level	"greater than normal blood concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv
MP:0003711	abnormal pathological neovascularization	"the proliferation of blood vessels in abnormal tissues or in abnormal positions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0003884	decreased macrophage count	"fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Nr3c1^tm1Dage/Nr3c1^tm1Dage Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL
MP:0003915	increased left ventricle weight	"greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0003962	abnormal adrenaline level	"aberrant concentration in the blood or tissues of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003964	abnormal noradrenaline level	"aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004202	pulmonary hyperplasia	"overdevelopment or increased size, usually due an increased number of cells of the respiratory organ in all or part of the organ" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
MP:0004215	abnormal myocardial fiber physiology	"anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0004231	abnormal calcium ion homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0004564	enlarged myocardial fiber	"increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0004733	abnormal thoracic cavity	"any structural anomaly of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0004780	abnormal surfactant secretion	"anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
MP:0004799	increased susceptibility to experimental autoimmune encephalomyelitis	"greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm3Gsc/Nr3c1^tm3Gsc Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Tg(Lck-cre)I57Jxm/0 Genetic Background: B6.Cg-Nr3c1^tm2Gsc Tg(Lck-cre)I57Jxm
MP:0004875	increased mean arterial blood pressure	"increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Dage/Nr3c1^tm1Dage Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL Allelic Composition: Nr3c1^tm1Dage/Nr3c1⁺ Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL
MP:0005006	abnormal osteoblast function	"anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lrp4^tm2Her/Lrp4^tm2Her Genetic Background: involves: 129S/SvEv Allelic Composition: Nr3c1^tm2.1Gsc/Nr3c1^tm2.1Gsc Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nr3c1^tm1Dage/Nr3c1^tm1Dage Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL Allelic Composition: Nr3c1^tm1Dage/Nr3c1⁺ Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Scn1a^tm2.1Wac/Scn1a⁺,Tg(I12b-cre)1Jlr/0 Genetic Background: involves: C57BL/6J * CD-1 Allelic Composition: Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda,Tcra^tm1Mom/Tcra^tm1Mom,Tg(Lck-cre)548Jxm/0 Genetic Background: B6.Cg-Tcra^tm1Mom Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm Allelic Composition: Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda,Tg(Lck-cre)548Jxm/0 Genetic Background: B6.Cg-Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm
MP:0005129	increased adrenocorticotropin level	"increased concentration of adrenocorticotropic hormone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rxra^tm2Ipc/Rxra⁺ Genetic Background: involves: 129/Sv
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0005167	abnormal blood-brain barrier	"anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nr3c1^tm3Gsc/Nr3c1^tm3Gsc Genetic Background: involves: 129P2/OlaHsd
MP:0005345	abnormal circulating corticosterone level	"anomalous blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺ Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs}
MP:0005582	increased renin activity	"greater than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺ Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs}
MP:0005630	increased lung weight	"greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
MP:0005645	abnormal hypothalamus physiology	"anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nr3c1^tm1.1Mvc/Nr3c1⁺,Tg(Sim1-cre)1Lowl/0 Genetic Background: involves: 129 * C57BL/6 * FVB
MP:0005664	decreased circulating noradrenaline level	"less than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Nr3c1^tm2.1Gsc/Nr3c1^tm2.1Gsc Genetic Background: involves: 129P2/OlaHsd
MP:0006027	impaired alveologenesis	"a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0006144	increased systolic blood pressure	"abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺ Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs}
MP:0006269	abnormal mammary gland growth during pregnancy	"anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Jak3^tm1Flv/Jak3^tm1Flv Genetic Background: involves: 129S1/Sv
MP:0006375	increased circulating angiotensinogen level	"greater than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺ Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs}
MP:0006414	decreased T cell apoptosis	"decrease in the number of T cells undergoing programmed cell death" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm3Gsc/Nr3c1^tm3Gsc Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Tg(Lck-cre)I57Jxm/0 Genetic Background: B6.Cg-Nr3c1^tm2Gsc Tg(Lck-cre)I57Jxm
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Dage/Nr3c1^tm1Dage Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL Allelic Composition: Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda,Tg(Lck-cre)548Jxm/0 Genetic Background: B6.Cg-Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Dage/Nr3c1^tm1Dage Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL Allelic Composition: Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda,Tg(Lck-cre)548Jxm/0 Genetic Background: B6.Cg-Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm
MP:0008083	decreased single-positive T cell number	"reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda,Tg(Lck-cre)548Jxm/0 Genetic Background: B6.Cg-Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm
MP:0008236	decreased susceptibility to neuronal excitotoxicity	"less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm2.1Ljm/Nr3c1^tm2.1Ljm,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Tg(Runx2-icre)1Jtuc/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0008288	abnormal adrenal cortex morphology	"any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008292	enlarged adrenocortical cell nuclei	"nuclei of the cells of the cortex of the adrenal gland are larger than normal" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008293	abnormal zona glomerulosa morphology	"any structural anomaly of the narrow subcapsular outer zone of the adrenal cortex where aldosterone is produced" [MESH:A06.407.071.140.960, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺ Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs}
MP:0008294	abnormal zona fasciculata morphology	"any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺ Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs} Allelic Composition: Nr3c1^tm1Dage/Nr3c1^tm1Dage Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL Allelic Composition: Nr3c1^tm1Dage/Nr3c1⁺ Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL
MP:0008295	abnormal zona reticularis morphology	"any structural anomaly of the inner zone of the adrenal cortex that produces the enzymes that convert pregnenolone, a 21-carbon steroid, to 19-carbon steroids" [MESH:A06.407.071.140.970]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008302	thin adrenal cortex	"reduced thickness of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Dage/Nr3c1^tm1Dage Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL Allelic Composition: Nr3c1^tm1Dage/Nr3c1⁺ Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL
MP:0008395	abnormal osteoblast differentiation	"atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Tg(Runx2-icre)1Jtuc/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Nr3c1^tm2.1Gsc/Nr3c1^tm2.1Gsc Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
MP:0008504	abnormal adrenal chromaffin cell morphology	"any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine and norepinephrine secretion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Nr3c1^tm2.1Gsc/Nr3c1^tm2.1Gsc Genetic Background: involves: 129P2/OlaHsd
MP:0008657	increased interleukin-1 beta secretion	"increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Nr3c1^tm2.1Ljm/Nr3c1^tm2.1Ljm,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0008704	abnormal interleukin-6 secretion	"anomaly in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Nr3c1^tm2.1Ljm/Nr3c1^tm2.1Ljm,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
MP:0008735	increased susceptibility to endotoxin shock	"more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kit^W-42J/Kit⁺,X/Sry^POS-TIR Genetic Background: involves: C57BL/6J
MP:0008750	abnormal interferon level	"deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]	Show Allelic Composition: Kit^W-42J/Kit⁺,X/Sry^POS-TIR Genetic Background: involves: C57BL/6J
MP:0008751	abnormal interleukin level	"deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: Kit^W-42J/Kit⁺,X/Sry^POS-TIR Genetic Background: involves: C57BL/6J
MP:0008752	abnormal tumor necrosis factor level	"deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]	Show Allelic Composition: Kit^W-42J/Kit⁺,X/Sry^POS-TIR Genetic Background: involves: C57BL/6J
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd
MP:0008872	abnormal response to xenobiotics	"any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1Dage/Nr3c1^tm1Dage Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL Allelic Composition: Nr3c1^tm1Dage/Nr3c1⁺ Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL
MP:0008874	decreased sensitivity to xenobiotics	"increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Tg(Lck-cre)I57Jxm/0 Genetic Background: B6.Cg-Nr3c1^tm2Gsc Tg(Lck-cre)I57Jxm
MP:0008973	decreased erythroid progenitor cell number	"reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm2.1Gsc/Nr3c1^tm2.1Gsc Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Nr3c1^tm3Gsc/Nr3c1^tm3Gsc Genetic Background: involves: 129P2/OlaHsd
MP:0009258	abnormal thymocyte apoptosis	"change in the timing or the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893]	Show Allelic Composition: Lpl^tm1Sem/Lpl⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺ Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs}
MP:0009481	cecum inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kit^W-42J/Kit⁺,X/Sry^POS-TIR Genetic Background: involves: C57BL/6J
MP:0009506	abnormal mammary gland alveolus morphology	"any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Jak3^tm1Flv/Jak3^tm1Flv Genetic Background: involves: 129S1/Sv
MP:0009542	decreased thymocyte apoptosis	"reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda,Tg(Lck-cre)548Jxm/0 Genetic Background: B6.Cg-Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm Allelic Composition: Nr3c1^tm1.1Jda/Nr3c1⁺,Tg(Lck-cre)548Jxm/0 Genetic Background: B6.Cg-Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm
MP:0009748	abnormal behavioral response to addictive substance	"any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Tg(Drd1a-cre)AGsc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kit^W-42J/Kit⁺,X/Sry^POS-TIR Genetic Background: involves: C57BL/6J
MP:0010119	abnormal bone mineral density	"anomaly in the amount of mineral per square centimeter of bone (usually g/cm2), used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nr3c1^tm2Gsc/Nr3c1^tm2Gsc,Tg(Runx2-icre)1Jtuc/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0010810	increased type II pneumocyte number	"greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
MP:0010816	decreased type I pneumocyte number	"reduced number of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
MP:0011031	abnormal branching involved in terminal bronchiole morphogenesis	"anomaly in the process in which the branched structure of the terminal bronchioles are generated and organized" [MGI:csmith]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil Genetic Background: B6.Cg-Gpc3^tm1Fil
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Lpl^tm1Sem/Lpl⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nr3c1^tm2.1Gsc/Nr3c1^tm2.1Gsc Genetic Background: involves: 129P2/OlaHsd
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd * 129/Sv
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Nr3c1^tm1Gsc/Nr3c1^tm1Gsc Genetic Background: involves: 129P2/OlaHsd
MP:0011400	complete lethality	"all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]	Show Allelic Composition: Col1a1^{tm8(CAG-BDNF)Jae}/Col1a1⁺,Mecp2^tm1.1Jae/Y,Tg(Camk2a-cre)93Kln/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J
MP:0011925	abnormal heart echocardiography feature	"any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]	Show Allelic Composition: Nr3c1^tm1.1Jaci/Nr3c1^tm1.1Jaci,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6 * FVB/N
MP:0012441	abnormal monocyte cell number	"any deviation in the count of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, MGI:csmith]	Show Allelic Composition: Nr3c1^tm2.1Ljm/Nr3c1^tm2.1Ljm,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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