ENSDARG00000087646


Danio rerio

Features
Gene ID: ENSDARG00000087646
  
Biological name :runx1
  
Synonyms : runt-related transcription factor 1 / runx1
  
Possible biological names infered from orthology : Q01196
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 1362932
Gene end: 1402303
  
Corresponding Affymetrix probe sets: Dr.20968.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000112019
NCBI entrez gene - 58126     See in Manteia.
swissprot - F1QAL3
swissprot - Q9DGB8
ZFIN ID - ZDB-GENE-000605-1
Ensembl - ENSDARG00000087646
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RUNX1ENSGALG00000016022Gallus gallus
 RUNX1ENSG00000159216Homo sapiens
 Runx1ENSMUSG00000022952Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
runx2a / runt-related transcription factor 2a / RUNX2* / Q08775* / Q13950* / runt related transcription factor 2*ENSDARG0000004026159
runx2b / runt-related transcription factor 2bENSDARG0000005923355
runx3 / runt-related transcription factor 3 / Q13761* / Q64131*ENSDARG0000005282651


Protein motifs (from Interpro)
Interpro ID Name
 IPR000040  Acute myeloid leukemia 1 protein (AML1)/Runt
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013524  Runt domain
 IPR013711  Runx, C-terminal domain
 IPR016554  Runt-related transcription factor RUNX
 IPR027384  Runx, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IBA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0002062 chondrocyte differentiation IBA
 biological_processGO:0002573 myeloid leukocyte differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030097 hemopoiesis IBA
 biological_processGO:0030099 myeloid cell differentiation IMP
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030223 neutrophil differentiation IGI
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0045595 regulation of cell differentiation IBA
 biological_processGO:0045637 regulation of myeloid cell differentiation IMP
 biological_processGO:0045658 regulation of neutrophil differentiation IGI
 biological_processGO:0045660 positive regulation of neutrophil differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0098508 endothelial to hematopoietic transition IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IPI


Pathways (from Reactome)
Pathway description
Organic cation transport
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
RUNX1 regulates estrogen receptor mediated transcription
Regulation of RUNX1 Expression and Activity
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm absent , abnormal
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 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
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 ZFA:0000094 blood island blood island hematopoietic multipotent progenitor cell absent , abnormal
blood island myeloid cell absent , abnormal
blood island myeloid cell decreased amount , abnormal
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 ZFA:0000737 cranium cranium shape , abnormal
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 ZFA:0001094 whole organism whole organism decreased life span , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta absent , abnormal
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell absent , abnormal
ventral wall of dorsal aorta myeloid cell absent , abnormal
ventral wall of dorsal aorta myeloid cell decreased amount , abnormal
ventral wall of dorsal aorta hematopoietic stem cell decreased amount , abnormal
ventral wall of dorsal aorta neutrophil decreased amount , abnormal
ventral wall of dorsal aorta endothelial cell apoptotic , abnormal
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
ventral wall of dorsal aorta decreased amount , abnormal
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 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased amount , abnormal
hematopoietic stem cell aplastic , abnormal
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 ZFA:0009015 erythroid progenitor cell erythroid progenitor cell absent , abnormal
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 ZFA:0009049 mature neutrophil mature neutrophil decreased amount , abnormal
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 ZFA:0009141 macrophage macrophage increased amount , abnormal
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 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron increased amount , abnormal
Rohon-Beard neuron decreased amount , abnormal
Rohon-Beard neuron absent , abnormal
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 ZFA:0009250 lymphocyte lymphocyte decreased amount , abnormal
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 ZFA:0009265 monocyte monocyte decreased amount , abnormal
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 ZFA:0009323 thrombocyte thrombocyte decreased amount , abnormal
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 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
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 ZFA:0009352 neutrophil progenitor cell neutrophil progenitor cell decreased amount , abnormal
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 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010246 prmt1 / protein arginine methyltransferase 1 / Q99873* / Q9JIF0* / protein arginine N-methyltransferase 1*  / complex / reaction
 ENSDARG00000027391 ccnd3 / cyclin D3 / P30281* / P30282* / G1/S-specific cyclin-D3 *  / reaction / complex
 ENSDARG00000068436 Q6PI20 / h3f3b.1 / H3 histone, family 3B.1 / H3F3B* / H3F3C* / P84243* / Q6NXT2* / H3 histone family member 3C* / H3 histone family member 3B*  / complex
 ENSDARG00000070228 cdk6 / cyclin-dependent kinase 6 / Q00534* / Q64261*  / complex / reaction
 ENSDARG00000008904 smarca2 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 / P51531*  / complex / reaction
 ENSDARG00000033647 Q5U379 / smarcb1a / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a / Q9Z0H3* / Q12824* / SMARCB1* / SWI/SNF related, matrix associated, a...  / complex / reaction
 ENSDARG00000077226 smarca4a / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4a / P51532* / Q3TKT4* / SMARCA4* / SWI/SNF related, matrix associated, actin depe...  / complex / reaction
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / reaction / complex
 ENSDARG00000015427 hdac1 / histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / reaction / complex
 ENSDARG00000019459 elf2a / E74-like factor 2a (ets domain transcription factor) / ELF2* / Q9JHC9* / Q15723* / E74 like ETS transcription factor 2* / ETS-related transcription factor Elf-2 *  / complex / reaction
 ENSDARG00000105345 zgc:173552  / complex
 ENSDARG00000037383 pax5 / paired box 5 / Q02548* / Q02650* / Paired box protein Pax-5 *  / reaction / complex
 ENSDARG00000079716 sin3aa / SIN3 transcription regulator family member Aa / SIN3A* / Q96ST3* / Q60520* / SIN3 transcription regulator family member A* / Mus musculus transcriptional regulator, SIN3A (yeast) (...  / reaction / complex
 ENSDARG00000017397 smarcc1a / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a / P97496* / Q92922* / SMARCC1* / SWI/SNF related, matrix associated, actin depe...  / reaction / complex
 ENSDARG00000079626 elf2b / E74-like factor 2b (ets domain transcription factor) / ELF2* / Q15723* / E74 like ETS transcription factor 2*  / reaction / complex
 ENSDARG00000104609 crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*  / complex / reaction
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex / reaction
 ENSDARG00000112452 crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*  / reaction / complex
 ENSDARG00000059812 sin3ab / SIN3 transcription regulator family member Ab / SIN3A* / Q96ST3* / Q60520* / SIN3 transcription regulator family member A* / Mus musculus transcriptional regulator, SIN3A (yeast) (...  / reaction / complex
 ENSDARG00000069706 prmt6 / protein arginine methyltransferase 6 / Q96LA8*  / complex / reaction
 ENSDARG00000077946 smarcc2 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 / Q6PDG5* / Q8TAQ2* / SWI/SNF complex subunit SMARCC2 *  / complex / reaction
 ENSDARG00000004537 kmt2a / lysine (K)-specific methyltransferase 2A / P55200* / Q03164* / lysine methyltransferase 2A* / Mus musculus lysine (K)-specific methyltransferase 2A (Kmt2a), transcript variant 1, mRNA.*  / complex / reaction
 ENSDARG00000068401 yap1 / Q1L8J7 / Yes-associated protein 1 / P46937* / P46938*  / complex / reaction
 ENSDARG00000105359 Q4QRF4 / FP325123.1 / Histone H3.2   / complex






 

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