ENSMUSG00000005886


Mus musculus

Features
Gene ID: ENSMUSG00000005886
  
Biological name :Ncoa2
  
Synonyms : Ncoa2 / Nuclear receptor coactivator 2 / Q61026
  
Possible biological names infered from orthology : Q15596
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A3
Gene start: 13139105
Gene end: 13374083
  
Corresponding Affymetrix probe sets: 10353135 (MoGene1.0st)   1433118_at (Mouse Genome 430 2.0 Array)   1435233_at (Mouse Genome 430 2.0 Array)   1435234_at (Mouse Genome 430 2.0 Array)   1446827_at (Mouse Genome 430 2.0 Array)   1450458_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116641
Ensembl peptide - ENSMUSP00000006037
Ensembl peptide - ENSMUSP00000069509
Ensembl peptide - ENSMUSP00000080413
NCBI entrez gene - 17978     See in Manteia.
MGI - MGI:1276533
RefSeq - XM_017319243
RefSeq - XM_017319233
RefSeq - XM_017319234
RefSeq - XM_017319235
RefSeq - XM_017319237
RefSeq - XM_017319241
RefSeq - NM_001302702
RefSeq - NM_008678
RefSeq - XM_006495465
RefSeq - XM_011238351
RefSeq - XM_011238361
RefSeq - XM_017319229
RefSeq - XM_017319230
RefSeq - XM_017319231
RefSeq - XM_017319232
RefSeq Peptide - NP_001289631
RefSeq Peptide - NP_032704
swissprot - E9PV80
swissprot - Q61026
swissprot - D3Z4F6
Ensembl - ENSMUSG00000005886
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncoa2ENSDARG00000017929Danio rerio
 ENSGALG00000036017Gallus gallus
 ENSGALG00000045995Gallus gallus
 NCOA2ENSG00000140396Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*ENSMUSG0000002767841
Ncoa1 / P70365 / Nuclear receptor coactivator 1 / Q15788*ENSMUSG0000002064736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010011  Domain of unknown function DUF1518
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR014920  Nuclear receptor coactivator, Ncoa-type, interlocking
 IPR014935  Nuclear receptor coactivator, receptor-binding domain
 IPR017426  Nuclear receptor coactivator
 IPR028822  Nuclear receptor coactivator 2
 IPR032565  Domain of unknown function DUF4927
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily
 IPR037077  Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0010906 regulation of glucose metabolic process IMP
 biological_processGO:0030522 intracellular receptor signaling pathway IBA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0045475 locomotor rhythm IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:1904017 cellular response to Thyroglobulin triiodothyronine IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016922 nuclear receptor binding IEA
 molecular_functionGO:0017162 aryl hydrocarbon receptor binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0030375 thyroid hormone receptor coactivator activity IDA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Endogenous sterols
HATs acetylate histones
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
Show

Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Bmp5cfe-se7J/Bmp5cfe-se7J
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0003845 abnormal decidualization "disrupted proliferation, differentiation or transformation of endometrial stromal cells into decidual cells in the maternal uterus following embryo implantation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43609, J:48920]
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Allelic Composition: Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0006416 abnormal rete testis morphology "any structural anomaly of the network of canals at the termination of the straight tubules in the mediastinum testis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000047638 Nr1h4 / Q60641 / Bile acid receptor / Q96RI1* / nuclear receptor subfamily 1 group H member 4*  / complex / reaction
 ENSMUSG00000057672 Pkn1 / P70268 / Serine/threonine-protein kinase N1 / Q16512* / protein kinase N1*  / complex / reaction
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / reaction / complex
 ENSMUSG00000031540 Kat6a / lysine acetyltransferase 6A / Q92794*  / complex / reaction
 ENSMUSG00000046532 Ar / P19091 / Androgen receptor / P10275*  / complex / reaction
 ENSMUSG00000020647 Ncoa1 / P70365 / Nuclear receptor coactivator 1 / Q15788*  / reaction / complex






 

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