MP:0000221 | decreased WBC count | "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm5.1Pisc,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
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MP:0000245 | abnormal erythropoiesis | "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc Genetic Background: Not Specified
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MP:0000248 | macrocytosis | "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc Genetic Background: Not Specified
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MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno Genetic Background: Not Specified
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MP:0000281 | abnormal ventricular septum morphology | "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno Genetic Background: Not Specified
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MP:0000333 | decreased bone marrow cell number | "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Ccnd3tm1.1(Ccnd2)Iaai/Ccnd3tm1.1(Ccnd2)Iaai Genetic Background: involves: 129S6/SvEvTac
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MP:0000596 | abnormal liver development | "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc Genetic Background: Not Specified
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MP:0000706 | small thymus | "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ccnd3tm1.1(Ccnd2)Iaai/Ccnd3tm1.1(Ccnd2)Iaai Genetic Background: involves: 129S6/SvEvTac
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg Genetic Background: Not Specified
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MP:0001436 | abnormal suckling behavior | "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg Genetic Background: Not Specified
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MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno Genetic Background: Not Specified
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MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Ccnd3tm1.1(Ccnd2)Iaai/Ccnd3tm1.1(Ccnd2)Iaai Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Cdkn1btm1Mlf/Cdkn1btm1Mlf Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Rb1tm2Brn/Rb1tm2Brn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129 * C57BL/6 * CBA
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MP:0002024 | T cell derived lymphoma | "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Trp53tm1Tyj/Trp53tm1Tyj Genetic Background: involves: 129S2/SvPas
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Trp53tm1Tyj/Trp53tm1Tyj Genetic Background: involves: 129S2/SvPas
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MP:0002123 | abnormal hematopoiesis | "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno Genetic Background: Not Specified
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm5.1Pisc,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
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MP:0002192 | hydrops fetalis | "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno Genetic Background: Not Specified
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MP:0002296 | aspiration | "inspiration into the airways of fluid or any foreign material " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd2tm1Wbg/Ccnd2tm1Wbg Genetic Background: Not Specified
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MP:0002396 | abnormal hematopoietic system morphology/development | "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm5.1Pisc,Tg(CAG-cre/Esr1*)5Amc/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
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MP:0002401 | abnormal lymphopoiesis | "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno Genetic Background: Not Specified
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MP:0002594 | low mean erythrocyte count | "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc Genetic Background: Not Specified
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MP:0002811 | macrocytic anemia | "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc Genetic Background: Not Specified
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MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno Genetic Background: Not Specified
Allelic Composition: Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
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MP:0002984 | retina hypoplasia | "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc Genetic Background: Not Specified
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MP:0004808 | abnormal hematopoietic stem cell morphology | "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno Genetic Background: Not Specified
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MP:0004810 | decreased hematopoietic stem cell number | "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno Genetic Background: Not Specified
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MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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MP:0005090 | increased double-negative T cells count | "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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MP:0005092 | decreased double-positive T cell count | "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
Allelic Composition: Ccnd3tm1.1(Ccnd2)Iaai/Ccnd3tm1.1(Ccnd2)Iaai Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Cdkn1btm1Mlf/Cdkn1btm1Mlf Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Rb1tm2Brn/Rb1tm2Brn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129 * C57BL/6 * CBA
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MP:0005093 | impaired B cell proliferation | "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Ccnd3tm1.1(Ccnd2)Iaai/Ccnd3tm1.1(Ccnd2)Iaai Genetic Background: involves: 129S6/SvEvTac
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MP:0005095 | decreased T cell proliferation | "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Ccnd3tm1.1(Ccnd2)Iaai/Ccnd3tm1.1(Ccnd2)Iaai Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Cdkn1btm1Mlf/Cdkn1btm1Mlf Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Rb1tm2Brn/Rb1tm2Brn,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129 * C57BL/6 * CBA
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MP:0005348 | increased T cell proliferation | "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Trp53tm1Tyj/Trp53tm1Tyj Genetic Background: involves: 129S2/SvPas
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MP:0006410 | abnormal common myeloid progenitor cell morphology | "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hand1tm1Eno/Hand1+,Hand2tm1Eno/Hand2tm1Eno Genetic Background: Not Specified
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MP:0008209 | decreased pre-B cell number | "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Ccnd3tm1.1(Ccnd2)Iaai/Ccnd3tm1.1(Ccnd2)Iaai Genetic Background: involves: 129S6/SvEvTac
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MP:0009278 | abnormal bone marrow cell physiology | "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccnd3tm1.1(Ccnd2)Iaai/Ccnd3tm1.1(Ccnd2)Iaai Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Cdkn1btm1Mlf/Cdkn1btm1Mlf Genetic Background: involves: 129S4/SvJaeSor
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MP:0010268 | decreased lymphoma incidence | "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh Genetic Background: involves: 129S6/SvEvTac
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MP:0010763 | abnormal hematopoietic stem cell physiology | "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
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MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc Genetic Background: Not Specified
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MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Ccnd1tm1Wbg/Ccnd1tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc Genetic Background: Not Specified
Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Ccnd2tm1Wbg/Ccnd2tm1Wbg,Ccnd3tm1Pisc/Ccnd3tm1Pisc Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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