ENSMUSG00000001833


Mus musculus

Features
Gene ID: ENSMUSG00000001833
  
Biological name :Sept7
  
Synonyms : Sept7 / septin-7 isoform 2
  
Possible biological names infered from orthology : Q16181 / septin 7
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A4
Gene start: 25252439
Gene end: 25308571
  
Corresponding Affymetrix probe sets: 10583905 (MoGene1.0st)   1437995_x_at (Mouse Genome 430 2.0 Array)   1438911_at (Mouse Genome 430 2.0 Array)   1454610_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127641
Ensembl peptide - ENSMUSP00000110927
NCBI entrez gene - 235072     See in Manteia.
MGI - MGI:1335094
RefSeq - XM_006510193
RefSeq - NM_009859
RefSeq - XM_006510190
RefSeq - XM_006510191
RefSeq - XM_006510192
RefSeq - NM_001205367
RefSeq Peptide - NP_033989
RefSeq Peptide - NP_001192296
swissprot - E9Q9F5
swissprot - E9Q1G8
Ensembl - ENSMUSG00000001833
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sept7aENSDARG00000087647Danio rerio
 sept7bENSDARG00000052673Danio rerio
 SEPT7ENSGALG00000032830Gallus gallus
 SEPT7ENSG00000122545Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sept4 / P28661 / Septin-4 / O43236*ENSMUSG0000002048646
Sept2 / P42208 / septin 2 / Q15019*ENSMUSG0000002627645
Sept2 / P42208 / Septin-2 / Q15019*ENSMUSG0000011604845
Sept5 / Q9Z2Q6 / Septin-5 / Q99719* / AC000093.1*ENSMUSG0000007221445
Sept1 / P42209 / Septin-1 ENSMUSG0000000048642
Sept9 / Q80UG5 / Septin-9 / Q9UHD8*ENSMUSG0000005924836
Sept3 / Q9Z1S5 / Neuronal-specific septin-3 / Q9UH03* / septin 3*ENSMUSG0000002245633
Sept12 / septin 12 / Q8IYM1*ENSMUSG0000002254225


Protein motifs (from Interpro)
Interpro ID Name
 IPR008115  Septin 7
 IPR016491  Septin
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030379  Septin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0031105 septin complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0003707 increased nucleus count "greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis" [pg:Philip Groth submission]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0003903 increased cell mass "greater total physical bulk or volume of a cell compared to the normal state" [RGD:Rat Genome Database submission]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0013289 abnormal mitotic cytokinesis "any anomaly in the process that results in the division of the cytoplasm of a cell after mitosis, this process consists of two distinct processes furrowing and abscission" [GO:0000281, MGI:smb]
Show

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042688 Mapk6 / Q61532 / Mitogen-activated protein kinase 6 / Q16659*  / reaction / complex
 ENSMUSG00000063838 Q9Z0X0 / 1700027J19Rik / CDC42 effector protein (Rho GTPase binding) 5 / Q6NZY7* / CDC42EP5* / CDC42 effector protein 5*  / reaction
 ENSMUSG00000045664 Q8JZX9 / Cdc42ep2 / Cdc42 effector protein 2 / O14613*  / reaction
 ENSMUSG00000029454 O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*  / reaction / complex
 ENSMUSG00000036533 Q9CQC5 / Cdc42ep3 / Cdc42 effector protein 3 / Q9UKI2*  / reaction






 

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