ENSMUSG00000020486


Mus musculus

Features
Gene ID: ENSMUSG00000020486
  
Biological name :Sept4
  
Synonyms : P28661 / Sept4 / Septin-4
  
Possible biological names infered from orthology : O43236
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 87568903
Gene end: 87590539
  
Corresponding Affymetrix probe sets: 10380067 (MoGene1.0st)   1448729_a_at (Mouse Genome 430 2.0 Array)   1455422_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018544
Ensembl peptide - ENSMUSP00000060127
Ensembl peptide - ENSMUSP00000103594
Ensembl peptide - ENSMUSP00000103595
Ensembl peptide - ENSMUSP00000115682
Ensembl peptide - ENSMUSP00000115790
Ensembl peptide - ENSMUSP00000103596
Ensembl peptide - ENSMUSP00000112960
NCBI entrez gene - 18952     See in Manteia.
MGI - MGI:1270156
RefSeq - XM_006532501
RefSeq - NM_001284392
RefSeq - NM_001284394
RefSeq - NM_001284398
RefSeq - NM_011129
RefSeq - XM_006532493
RefSeq - XM_006532494
RefSeq - XM_006532496
RefSeq - XM_006532497
RefSeq - XM_006532498
RefSeq - XM_006532499
RefSeq Peptide - NP_035259
RefSeq Peptide - NP_001271321
RefSeq Peptide - NP_001271323
RefSeq Peptide - NP_001271327
swissprot - Q5ND13
swissprot - P28661
swissprot - Q5ND09
swissprot - Q5ND18
Ensembl - ENSMUSG00000020486
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SEPT4ENSDARG00000105271Danio rerio
 sept4aENSDARG00000010385Danio rerio
 zgc:162239ENSDARG00000019651Danio rerio
 SEPT4ENSGALG00000035185Gallus gallus
 SEPT4ENSG00000108387Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sept5 / Q9Z2Q6 / Septin-5 / Q99719* / AC000093.1*ENSMUSG0000007221459
Sept1 / P42209 / Septin-1 ENSMUSG0000000048648
Sept2 / P42208 / septin 2 / Q15019*ENSMUSG0000002627646
Sept2 / P42208 / Septin-2 / Q15019*ENSMUSG0000011604846
Sept7 / septin-7 isoform 2 / Q16181* / septin 7*ENSMUSG0000000183342
Sept9 / Q80UG5 / Septin-9 / Q9UHD8*ENSMUSG0000005924835
Sept3 / Q9Z1S5 / Neuronal-specific septin-3 / Q9UH03* / septin 3*ENSMUSG0000002245632
Sept12 / septin 12 / Q8IYM1*ENSMUSG0000002254226


Protein motifs (from Interpro)
Interpro ID Name
 IPR016491  Septin
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030379  Septin-type guanine nucleotide-binding (G) domain
 IPR030643  Septin 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030382 sperm mitochondrion organization IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination ISO
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0048240 sperm capacitation IMP
 biological_processGO:0051260 protein homooligomerization ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031105 septin complex ISO
 cellular_componentGO:0031514 motile cilium IMP
 cellular_componentGO:0036126 sperm flagellum IDA
 cellular_componentGO:0042995 cell projection IDA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0097227 sperm annulus ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0042803 protein homodimerization activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Sept4tm1Hs/Sept4tm1Hs
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tiraptm1Medz/Tiraptm1Medz
Genetic Background: involves: 129S1/Sv

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Sept4tm1Hs/Sept4tm1Hs
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0003666 impaired sperm capacitation "anomaly in the change undergone by spermatozoa in the female genital tract that enables them to penetrate and fertilize an egg" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96669]
Show

Allelic Composition: Sept4tm1Hs/Sept4tm1Hs
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sept4tm1Hs/Sept4tm1Hs
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Sept4tm1Hs/Sept4+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0009242 thin sperm flagellum "reduced thickness of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sept4tm1Hs/Sept4tm1Hs
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0009243 hairpin sperm flagellum "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sept4tm1Hs/Sept4tm1Hs
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Sept4tm1Hs/Sept4tm1Hs
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0009835 absent sperm annulus "absence of the ring-like, filamentous structure located at the midpiece-principal piece junction of the sperm flagellum, usually associated with a bent tail morphology" [PMID:14581499]
Show

Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Sept4tm1Hs/Sept4tm1Hs
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

 MP:0009836 abnormal sperm principal piece morphology "any structural abnormality in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499]
Show

Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Sept4tm1Hs/Sept4tm1Hs
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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