ENSMUSG00000059248


Mus musculus

Features
Gene ID: ENSMUSG00000059248
  
Biological name :Sept9
  
Synonyms : Q80UG5 / Sept9 / Septin-9
  
Possible biological names infered from orthology : Q9UHD8
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 117199661
Gene end: 117362325
  
Corresponding Affymetrix probe sets: 10382912 (MoGene1.0st)   1417038_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101961
Ensembl peptide - ENSMUSP00000101956
Ensembl peptide - ENSMUSP00000120065
Ensembl peptide - ENSMUSP00000120382
Ensembl peptide - ENSMUSP00000019038
Ensembl peptide - ENSMUSP00000091435
Ensembl peptide - ENSMUSP00000097767
NCBI entrez gene - 53860     See in Manteia.
MGI - MGI:1858222
RefSeq - XM_006533746
RefSeq - NM_001113486
RefSeq - NM_001113487
RefSeq - NM_001113488
RefSeq - NM_017380
RefSeq - XM_006533744
RefSeq - XM_006533745
RefSeq Peptide - NP_001106958
RefSeq Peptide - NP_001106959
RefSeq Peptide - NP_001106960
RefSeq Peptide - NP_059076
swissprot - Q80UG5
swissprot - A2A6U3
swissprot - A8Y5D3
swissprot - A2A6U5
Ensembl - ENSMUSG00000059248
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sept9aENSDARG00000020235Danio rerio
 sept9bENSDARG00000103900Danio rerio
 SEPT9ENSGALG00000040244Gallus gallus
 SEPT9ENSG00000184640Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sept3 / Q9Z1S5 / Neuronal-specific septin-3 / Q9UH03* / septin 3*ENSMUSG0000002245639
Sept12 / septin 12 / Q8IYM1*ENSMUSG0000002254230
Sept4 / P28661 / Septin-4 / O43236*ENSMUSG0000002048628
Sept7 / septin-7 isoform 2 / Q16181* / septin 7*ENSMUSG0000000183327
Sept2 / P42208 / septin 2 / Q15019*ENSMUSG0000002627625
Sept5 / Q9Z2Q6 / Septin-5 / Q99719* / AC000093.1*ENSMUSG0000007221425
Sept2 / P42208 / Septin-2 / Q15019*ENSMUSG0000011604825
Sept1 / P42209 / Septin-1 ENSMUSG0000000048623


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR016491  Septin
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030379  Septin-type guanine nucleotide-binding (G) domain
 IPR030645  Septin 9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0051291 protein heterooligomerization ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:1902857 positive regulation of non-motile cilium assembly ISO
 cellular_componentGO:0001725 stress fiber ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005930 axoneme ISO
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0031105 septin complex ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0097730 non-motile cilium ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Sept9tm2.2Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0010133 increased DN3 thymocyte number "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0010836 decreased CD4-positive, alpha-beta memory T cell number "reduced number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0010838 increased CD8-positive, alpha-beta memory T cell number "increased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0010839 decreased CD8-positive, alpha-beta memory T cell number "decreased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
Show

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Sept9tm2.2Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

Allelic Composition: Sept9tm1Emfu/Sept9tm2.2Emfu
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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