ENSMUSG00000022542


Mus musculus

Features
Gene ID: ENSMUSG00000022542
  
Biological name :Sept12
  
Synonyms : Sept12 / septin 12
  
Possible biological names infered from orthology : Q8IYM1
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 4986858
Gene end: 4997852
  
Corresponding Affymetrix probe sets: 10437472 (MoGene1.0st)   1438298_a_at (Mouse Genome 430 2.0 Array)   1460497_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131062
Ensembl peptide - ENSMUSP00000154901
Ensembl peptide - ENSMUSP00000155459
NCBI entrez gene - 71089     See in Manteia.
MGI - MGI:1918339
RefSeq - XM_006522580
RefSeq - NM_027669
RefSeq - NM_029374
RefSeq - XM_006522577
RefSeq - XM_006522578
RefSeq - XM_006522579
RefSeq Peptide - NP_081945
RefSeq Peptide - NP_083650
swissprot - Q9D451
swissprot - Q9D9U8
Ensembl - ENSMUSG00000022542
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sept12ENSDARG00000019191Danio rerio
 SEPT12ENSGALG00000029027Gallus gallus
 Q8IYM1ENSG00000140623Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sept9 / Q80UG5 / Septin-9 / Q9UHD8*ENSMUSG0000005924855
Sept3 / Q9Z1S5 / Neuronal-specific septin-3 / Q9UH03* / septin 3*ENSMUSG0000002245649
Sept4 / P28661 / Septin-4 / O43236*ENSMUSG0000002048638
Sept2 / P42208 / septin 2 / Q15019*ENSMUSG0000002627635
Sept5 / Q9Z2Q6 / Septin-5 / Q99719* / AC000093.1*ENSMUSG0000007221435
Sept2 / P42208 / Septin-2 / Q15019*ENSMUSG0000011604835
Sept1 / P42209 / Septin-1 ENSMUSG0000000048634
Sept7 / septin-7 isoform 2 / Q16181* / septin 7*ENSMUSG0000000183334


Protein motifs (from Interpro)
Interpro ID Name
 IPR016491  Septin
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030379  Septin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0097722 sperm motility IMP
 cellular_componentGO:0005819 spindle ISO
 cellular_componentGO:0015630 microtubule cytoskeleton ISO
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031105 septin complex ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0097227 sperm annulus ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0008545 absent sperm flagella "mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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