ENSG00000108387


Homo sapiens

Features
Gene ID: ENSG00000108387
  
Biological name :SEPT4
  
Synonyms : O43236 / SEPT4 / septin 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q22
Gene start: 58520250
Gene end: 58540818
  
Corresponding Affymetrix probe sets: 210348_at (Human Genome U133 Plus 2.0 Array)   210657_s_at (Human Genome U133 Plus 2.0 Array)   233006_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464382
Ensembl peptide - ENSP00000464360
Ensembl peptide - ENSP00000464373
Ensembl peptide - ENSP00000321071
Ensembl peptide - ENSP00000321674
Ensembl peptide - ENSP00000376801
Ensembl peptide - ENSP00000402000
Ensembl peptide - ENSP00000402348
Ensembl peptide - ENSP00000414779
Ensembl peptide - ENSP00000462278
Ensembl peptide - ENSP00000462362
Ensembl peptide - ENSP00000462727
Ensembl peptide - ENSP00000463461
Ensembl peptide - ENSP00000463671
Ensembl peptide - ENSP00000463768
NCBI entrez gene - 5414     See in Manteia.
OMIM - 603696
RefSeq - XM_011524912
RefSeq - NM_001198713
RefSeq - NM_001256782
RefSeq - NM_001256822
RefSeq - NM_004574
RefSeq - NM_080415
RefSeq - NM_080416
RefSeq - XM_006721949
RefSeq - XM_006721950
RefSeq - XM_006721951
RefSeq - XM_006721952
RefSeq - XM_006721954
RefSeq - XM_006721955
RefSeq - XM_011524911
RefSeq Peptide - NP_001243751
RefSeq Peptide - NP_004565
RefSeq Peptide - NP_536340
RefSeq Peptide - NP_536341
RefSeq Peptide - NP_001243711
RefSeq Peptide - NP_001185642
swissprot - J3QRT6
swissprot - J3QRU3
swissprot - O43236
swissprot - J3KS26
swissprot - J3KS85
swissprot - J3KSZ7
swissprot - J3QLA8
swissprot - J3QLR2
swissprot - J3QRS4
Ensembl - ENSG00000108387
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SEPT4ENSDARG00000105271Danio rerio
 sept4aENSDARG00000010385Danio rerio
 zgc:162239ENSDARG00000019651Danio rerio
 SEPT4ENSGALG00000035185Gallus gallus
 Sept4ENSMUSG00000020486Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SEPT5 / Q99719 / septin 5ENSG0000018470258
AC000093.1ENSG0000028487458
SEPT1 / septin 1ENSG0000018009648
SEPT2 / Q15019 / septin 2ENSG0000016838544
SEPT7 / Q16181 / septin 7ENSG0000012254536
SEPT9 / Q9UHD8 / septin 9ENSG0000018464034
SEPT3 / Q9UH03 / septin 3ENSG0000010016732
Q8IYM1 / SEPT12 / septin 12ENSG0000014062329


Protein motifs (from Interpro)
Interpro ID Name
 IPR016491  Septin
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030379  Septin-type guanine nucleotide-binding (G) domain
 IPR030643  Septin 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030382 sperm mitochondrion organization IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0042981 regulation of apoptotic process NAS
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0048240 sperm capacitation IEA
 biological_processGO:0051260 protein homooligomerization IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion NAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031105 septin complex IDA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0036126 sperm flagellum IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0097227 sperm annulus IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IMP
 molecular_functionGO:0003924 GTPase activity IMP
 molecular_functionGO:0005198 structural molecule activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IMP
 molecular_functionGO:0042803 protein homodimerization activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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