Manteia - Molecule gene

ENSMUSG00000031871

Mus musculus

Features

Gene ID:	ENSMUSG00000031871

Biological name :	Cdh5

Synonyms :	Cadherin-5 / Cdh5 / P55284

Possible biological names infered from orthology :	P33151

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	D3
Gene start:	104101625
Gene end:	104144511

Corresponding Affymetrix probe sets:	10574438 (MoGene1.0st) 1422047_at (Mouse Genome 430 2.0 Array) 1433956_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000147286 Ensembl peptide - ENSMUSP00000034339 NCBI entrez gene - 12562 See in Manteia. MGI - MGI:105057 RefSeq - NM_009868 RefSeq - XM_006530630 RefSeq Peptide - NP_033998 swissprot - A0A1B0GQW9 swissprot - P55284 Ensembl - ENSMUSG00000031871

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
cdh5	ENSDARG00000075549	Danio rerio
CDH5	ENSGALG00000032349	Gallus gallus
CDH5	ENSG00000179776	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000233	Cadherin, cytoplasmic domain
IPR002126	Cadherin
IPR015919	Cadherin-like
IPR020894	Cadherin conserved site
IPR027397	Catenin binding domain superfamily
IPR030052	VE-cadherin

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001955	blood vessel maturation	IMP
biological_process	GO:0007043	cell-cell junction assembly	IEA
biological_process	GO:0007155	cell adhesion	IEA
biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	IEA
biological_process	GO:0007179	transforming growth factor beta receptor signaling pathway	IEA
biological_process	GO:0008285	negative regulation of cell proliferation	IGI
biological_process	GO:0045766	positive regulation of angiogenesis	IEA
biological_process	GO:0050728	negative regulation of inflammatory response	IEA
biological_process	GO:0098609	cell-cell adhesion	IMP
biological_process	GO:1903142	positive regulation of establishment of endothelial barrier	IEA
biological_process	GO:2000114	regulation of establishment of cell polarity	IEA
cellular_component	GO:0005886	plasma membrane	IDA
cellular_component	GO:0005911	cell-cell junction	IEA
cellular_component	GO:0005912	adherens junction	IDA
cellular_component	GO:0005913	cell-cell adherens junction	IDA
cellular_component	GO:0005923	bicellular tight junction	IDA
cellular_component	GO:0009897	external side of plasma membrane	IDA
cellular_component	GO:0009986	cell surface	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0071944	cell periphery	IDA
molecular_function	GO:0005102	signaling receptor binding	IEA
molecular_function	GO:0005509	calcium ion binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008013	beta-catenin binding	IEA
molecular_function	GO:0019903	protein phosphatase binding	IPI
molecular_function	GO:0044325	ion channel binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Adherens junctions interactions

VEGFR2 mediated vascular permeability

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0000259	abnormal vascular development	"malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]	Show Allelic Composition: Lama2^dy-6J/Lama2^dy-6J Genetic Background: involves: C57BL/6JEi * DBA/2J Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0000260	abnormal angiogenesis	"aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lama2^dy-6J/Lama2^dy-6J Genetic Background: involves: C57BL/6JEi * DBA/2J Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0000292	distended pericardial sacs	"stretched outer parietal layer of the pericardium" [J:25248]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0000313	abnormal cell death	"anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0000600	liver hypoplasia	"reduced size of liver due to decreased cell number " [J:57631]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0000601	small liver	"reduced size of the liver" [J:23170]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0001120	abnormal uterus morphology	"malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0001619	abnormal vascular permeability	"anomaly in the ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0001622	abnormal vasculogenesis	"aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB Allelic Composition: Cdh5^tm1Hub/Cdh5^tm1Hub Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Cdh5^tm1.1Pec/Cdh5^tm1.1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0001636	irregular heartbeat	"uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdh5^tm1.1Pec/Cdh5^tm1.1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0001689	incomplete somite formation	"arrest of differentiation or patterning of the somites" [J:62882]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0001701	incomplete embryo turning	"arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0001719	absent vitelline blood vessels	"missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Lama2^dy-6J/Lama2^dy-6J Genetic Background: involves: C57BL/6JEi * DBA/2J Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0001879	abnormal lymphatic vessel morphology	"malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0002016	ovarian cysts	"cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0002123	abnormal hematopoiesis	"abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0002792	abnormal retinal vascularization	"malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,S1pr1^tm2Rlp/S1pr1^tm2Rlp,Tg(Cdh5-cre/ERT2)1Rha/0 Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ
MP:0003070	increased vascular permeability	"greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0003071	decreased vascular permeability	"reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Is(14)1Rdf/Is(14)1Rdf,Is(14)5Rdf/Is(14)5Rdf,Cd19^tm1(cre)Cgn/Cd19⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6
MP:0003156	abnormal lymphocyte migration/homing	"altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0003229	abnormal vitelline vasculature	"malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]	Show Allelic Composition: Cdh5^tm1.1Pec/Cdh5^tm1.1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0003230	abnormal umbilical artery	"malformation of the blood vessel of the umbilical cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0003231	abnormal placental vasculature	"malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]	Show Allelic Composition: Cdh5^tm1.1Pec/Cdh5^tm1.1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0003390	lymphedema	"abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0003411	abnormal vein development	"anomaly in the process of forming the blood vessels that carry blood to the heart" [J:94740, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdh5^tm1.1Pec/Cdh5^tm1.1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0003542	abnormal vascular endothelial cell development	"malformation or aberrant differentiation of the cells that line the vasculature" [J:95387, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdh5^tm1.1Pec/Cdh5^tm1.1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0004068	dilated dorsal aorta	"an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0004832	enlarged ovary	"increased size of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0004906	enlarged uterus		Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0005501	abnormal skin physiology	"atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0005602	decreased angiogenesis	"reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdh5^tm1.1Pec/Cdh5^tm1.1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0006055	abnormal vascular endothelial cell morphology	"malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdh5^tm1.1Pec/Cdh5^tm1.1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0006346	small branchial arch	"reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdh5^tm1.1Pec/Cdh5^tm1.1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0006410	abnormal common myeloid progenitor cell morphology	"anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0008719	impaired neutrophil recruitment	"reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Is(14)1Rdf/Is(14)1Rdf,Is(14)5Rdf/Is(14)5Rdf,Cd19^tm1(cre)Cgn/Cd19⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6
MP:0009083	uterus hypertrophy	"increase in the bulk size of the female muscular organ of gestation due to cell enlargement" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0009251	enlarged endometrial glands	"increase in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0009444	ovarian follicular cyst	"a sac filled with fluid that may develop when the structure containing the egg fails to break open at the time of ovulation" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0009858	abnormal cellular extravasation	"any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 Allelic Composition: Cdh5^{tm4(Cdh5/Fkbp,Ptprb/Mtor)Dvst}/Cdh5^{tm4(Cdh5/Fkbp,Ptprb/Mtor)Dvst} Genetic Background: involves: C57BL/6 Allelic Composition: Cdh5^tm5Dvst/Cdh5^tm5Dvst Genetic Background: B6.Cg-Cdh5^tm5Dvst Allelic Composition: Cdh5^tm6Dvst/Cdh5^tm6Dvst Genetic Background: B6.Cg-Cdh5^tm6Dvst
MP:0010195	abnormal lymphatic vessel endothelium morphology	"any structural anomaly of the thin layer of flat cells that line the lymphatic vessels and form a barrier between circulating lymph in the lumen and the rest of the vessel wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0010197	abnormal lymphatic vessel endothelial cell morphology	"any structural anomaly of the cells that line the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0010763	abnormal hematopoietic stem cell physiology	"any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB Allelic Composition: Cdh5^tm1.1Pec/Cdh5^tm1.1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm7Dvst/Cdh5^tm7Dvst Genetic Background: Not Specified
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1
MP:0011204	abnormal visceral yolk sac blood island morphology	"any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0012082	delayed heart development	"late onset of the induction and/or differentiation of the heart" [MGI:anna]	Show Allelic Composition: Cdh5^tm1.1Pec/Cdh5^tm1.1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0012253	abnormal intersomitic vessel morphology	"any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB Allelic Composition: Cdh5^tm1.1Pec/Cdh5^tm1.1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm1Pec/Cdh5^tm1Pec Genetic Background: Not Specified Allelic Composition: Cdh5^tm2Pec/Cdh5^tm2Pec Genetic Background: Not Specified
MP:0012300	abnormal umbilical cord blood vessel morphology	"any structural anomaly of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton s jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place; the umbilical vein carries oxygenated, nutrient-rich blood from the placenta to the fetus, and the umbilical arteries carry deoxygenated, nutrient-depleted blood from the fetus to the placenta" [MGI:anna]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Hubr/Prrx2^tm1Hubr Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB
MP:0013398	uterus fibrosis	"invasion of fibrous connective tissue into the uterus, often resulting from inflammation or injury" [MGI:Anna]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0013607	ovary fibrosis	"invasion of fibrous connective tissue into the ovary, often resulting from inflammation or injury" [MGI:Anna]	Show Allelic Composition: Cox10^tm1Ctm/Cox10^tm1Ctm,Slc6a3^{tm1.1(cre)Bkmn}/? Genetic Background: B6.Cg-Cox10^tm1Ctm Slc6a3^{tm1.1(cre)Bkmn}
MP:0013708	abnormal hematopoietic precursor cell number	"anomaly in the number of a hematopoietic cell that is a precursor of some other hematopoietic cell type" [CL:0008001]	Show Allelic Composition: Lin28a^tm1Gqda/Lin28a^tm1Gqda,Myf5^tm3(cre)Sor/Myf5⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000022781	Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*	/ reaction
ENSMUSG00000031284	Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*	/ reaction
ENSMUSG00000037815	Ctnna1 / P26231 / Catenin alpha-1 / P35221*	/ complex
ENSMUSG00000101645	P30999 / Gm28635 / predicted gene 28635 / O60716* / CTNND1* / catenin delta 1*	/ complex
ENSMUSG00000001552	Jup / Q02257 / Junction plakoglobin / P14923*	/ complex
ENSMUSG00000030774	Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*	/ reaction

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