ENSDARG00000075549


Danio rerio

Features
Gene ID: ENSDARG00000075549
  
Biological name :cdh5
  
Synonyms : cadherin 5 / cdh5
  
Possible biological names infered from orthology : P33151 / P55284
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 44445595
Gene end: 44471544
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000104309
swissprot - F1R2I9
ZFIN ID - ZDB-GENE-040816-1
Ensembl - ENSDARG00000075549
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDH5ENSGALG00000032349Gallus gallus
 CDH5ENSG00000179776Homo sapiens
 Cdh5ENSMUSG00000031871Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdh24a / cadherin 24, type 2aENSDARG0000007596029


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily
 IPR030052  VE-cadherin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001955 blood vessel maturation IEA
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009826 unidimensional cell growth IMP
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0061300 cerebellum vasculature development IMP
 biological_processGO:0072554 blood vessel lumenization IMP
 biological_processGO:0120077 angiogenic sprout fusion IMP
 biological_processGO:0120078 cell adhesion involved in sprouting angiogenesis IGI
 biological_processGO:1902354 blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment IMP
 biological_processGO:1902355 endothelial tube lumen extension involved in blood vessel lumen ensheathment IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Adherens junctions interactions
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain blood vessel broken , abnormal
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 ZFA:0000009 cardiac ventricle cardiac ventricle elongated , abnormal
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 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
anatomical structure decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
pericardium increased size , abnormal
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 ZFA:0000154 sinus venosus sinus venosus increased accumulation blood , abnormal
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 ZFA:0000186 common cardinal vein common cardinal vein decreased length , abnormal
common cardinal vein blood vessel endothelial cell migration disrupted , abnormal
common cardinal vein blood vessel endothelial cell structure, cavities , abnormal
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 ZFA:0000471 atrium atrium elongated , abnormal
atrium dilated , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature hemorrhagic , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel cortical actin cytoskeleton disorganized , abnormal
intersegmental vessel dorsal region lacks parts or has fewer parts of type endothelial cell cell junction, abnormal
intersegmental vessel angiogenesis process quality , abnormal
intersegmental vessel cell junction morphology , abnormal
intersegmental vessel endothelial tip cell dissociated from intersegmental vessel vascular sprouts, abnormal
intersegmental vessel unlumenized , abnormal
intersegmental vessel branchiness , abnormal
intersegmental vessel blood vessel lumenization absent , abnormal
intersegmental vessel disorganized , abnormal
intersegmental vessel has extra parts of type intersegmental vessel filopodium, abnormal
intersegmental vessel unidimensional cell growth process quality , abnormal
intersegmental vessel mislocalised , abnormal
intersegmental vessel disconnected , abnormal
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 ZFA:0001317 endocardial cushion endocardial cushion morphology , abnormal
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 ZFA:0001318 cardiac jelly cardiac jelly physical quality , abnormal
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 ZFA:0001374 atrial myocardium atrial myocardium contractility , abnormal
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 ZFA:0001614 atrial endocardium atrial endocardium structure , abnormal
atrial endocardium cell-cell junction decreased size , abnormal
atrial endocardium cell-cell junction decreased amount , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel malformed , abnormal
dorsal longitudinal anastomotic vessel blood vessel development delayed , abnormal
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 ZFA:0005604 angiogenic sprout angiogenic sprout endothelial tip cell detached from angiogenic sprout , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
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 ZFA:0009303 endothelial tip cell endothelial tip cell cell adhesion decreased efficacy , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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